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144 Cards in this Set

  • Front
  • Back
True/False
The hormone gastrin is released in response to the pH of duodenal contents falling below 3.5 and is released to slow gastric emptying.
False. secretin.
Chyme with a pH below 3.5 entering the duodenum results in the release of the hormone:
a. secretin
b. some unknown hormone
c. gastrin
d. cholecystokinin
a. secretin
True/False
Peptic ulcers are chronic, usually solitary, ulcerations of the upper GI tract occurring most frequently in the duodenum and stomach.
True
True/False
The parotid salivary glands secrete glycoprotein mucins and salivary amylase.
False. secrete salivary amylase only.
True/False
The only non-mixed (pure serous) salivary gland is the submandibular gland.
False. is the parotid gland.
True/False
Enterochromaffin-like (ECL) cells release the parietal cell secretagogue gastrin.
False. release parietal cell secretagogue histamine.
__________________ cells, located in the gastric pits, differentiate into columnar epithelial cells that migrate to the luminal surface of the stomach.
Mucous neck
The pancreatic products chymotrypsinogen and procarboxypeptidase are converted to their active form by the action of _____________.
trypsin
The limiting step in the absorption of lipid materials is the diffusion of _______________ through the intestinal unstirred surface layer.
micelles
True/False
Hydrogen ions are moved into the lumen of the gastric glands by primary active transport.
True
True/False
Mucous neck cells, located in the gastric pits, differentiate into columnar epithelial cells that migrate to the luminal surface of the stomach.
True
True/False
The cephalic phase of the control of gastric acid secretion is mediated entirely by the vagus.
True
Bicarb (HCO3-) leaves the parietal cells by:
a. Facilitated diffusion
b. Countertransport with Cl-
c. Countertransport with Na+
d. Primary active transport
b. Countertransport with Cl-
True/False
The parotid glands contain serous acinar cells that secrete salivary amylase and mucins.
False. salivary amylase only.
In salivary secretion, stimulation of the (a)_________ nerves cause the release of (b)____________ which binds to (c)____________ receptor in the basolateral surface of the cell. Activation of these receptors cause increases in (d)______________ and subsequent release of amylase
(a) parasympathetic
(b) acetylcholine or ACh
(c) M3R
(d) IP3 or DAG or Ca++ (calcium)
True/False
Concerning the ionic composition of saliva, potassium is always higher and bicarbonate exceeds that of plasma except at very low rates of secretion.
True
True/False
HCO3-, generated during the intracellular production of H+, leaves the parietal cells by countertransport with CI- and is carried away by the venous blood.
True
Parietal (oxyntic) cells secrete __________ and ____________.
HCl and intrinsic factor
The two blood supplies to the liver are via the _________________ and the _________________. (Name of vessels)
hepatic artery
hepatic portal vein
Bile enters the duodenum through the __________________.
Sphincter of Oddi
True/False
Chyme entering the duodenum that has a pH below 3.5 causes the release of secretin, which slows gastric emptying and inhibits the release of gastrin.
True
True/False
Peristalsis consists of moving waves of contracted circular muscle preceded by an area of relaxed muscle that sweeps the entire length of the small intestine.
False. sweeps a small distance.
True/False
Beta-adrenergic stimulation of the parotid salivary glands produces a secretion that is richer in amylase.
True
True/False
Oxyntic cells secrete the family of proteolytic proenzymes known as the pepsinogens.
False. Chief or peptic cells.
True/False
Optimal activity for salivary amylase and the pepsins occurs when the pH is 7.
False. for salivary amylase only occurs
True/False
Potassium ions enter the lumen of the gastric glands by primary active transport.
False. enter the parietal cell of the gastric glands
True/False
The tall columnar epithelial cells that line the lumen of the stomach differentiate from the mucous neck cells found in the gastric pits.
True
True/False
Cl- concentration is higher in the cytoplasm parietal cell than in plasma.
True
True/False
The control of gastric acid secretion during the cephalic phase is mediated entirely by the vagus nerve.
True
True/False
Chymotrypsinogen is activated by enteropeptidase.
False. by trypsin.
True/False
The amount of lecithin present determines the amount of cholesterol that can be dissolved in the micelles.
True
Bile enters the duodenum through the ________________________.
Sphincter of Oddi
Concerning the liver, which of the following is NOT true:
a. hepatocytes are arranged in plates that radiate out from the central vein
b. sinusoids are vascular spaces located between the plates of hepatocytes
c. sinusoids are lined with endothelial cells and Kupffer Cells
d. bile is secreted into canaliculi and flows into bile ducts located in the center of each lobule
e. all of the above are true
d. bile is secreted into canaliculi and flows into bile ducts located in the center of each lobule
True/False
Chymotrypsinogen and procarboxypeptidase are cleaved to their active forms by enteropeptidase (enterokinase).
False. by trypsin.
True/False
The gallbladder is drained by the cystic duct.
True
True/False
The more lecithin present in the micelles, the less cholesterol can be dissolved.
False. more cholesterol
The acinar cells of the pancreas are stimulated to secrete the enzyme component of pancreatic juice by the secretogogue:
a. secretin
b. cholecystokinin
c. histamine
d. epinephrine
b. cholecystokinin
Between meals bile secreted by the liver is stored and concentrated in the gallbladder. After the start of a meal however, the gallbladder begins emptying the bile into the duodenum. Which of the following is a TRUE statement:
A.In the initial phase, consistent contraction of the gallbladder force bile through the sphincter of Oddi
B.All three phases of digestion elicit similar rates of gallbladder empting
C.Stimulation of sympathetic nerve to the gallbladder inhibits emptying of the gallbladder
D.During the intestinal phase of digestion contraction and relaxation are mostly mediated by the cholinergic signaling elicited by the vagus nerve and gastrin release from the stomach.
E.None of the above.
C.Stimulation of sympathetic nerve to the gallbladder inhibits emptying of the gallbladder
True/False
Bicarb (HCO-3) enters the ileum and colon by countertransport with Cl- for a net loss.
True
True/False
The epithelial cells of the stomach secrete mucous and bicarbonate that make the mucous layer acid and protect the surface of the stomach from damage by gastric content.
False. mucous layer alkaline
True/False
When the double mutant mice lacking IP3R2 and IP3R3 were fed a predigested diet containing glucose and amino acids for a week they gained weight. This data suggest that the digestive system dysfunction caused the malnutrition.
True
True/False
The cholinergic-induced stimulation of amylase production in the IP3R2/IP3R3 knockout mice was abolished by atropine.
False. unchanged
True/False
In salivary secretion, stimulation of the sympathetic nerves causes the release of Ca2+ and subsequent release of water.
False. parasympathetic nerves
True/False
The parietal cells are stimulated to secrete HCl-. G cells produce gastrin which also influences HCl- production.
True
Between meals bile secreted by the liver is stored and concentrated in the gallbladder. After the start of a meal however, the gallbladder begins emptying the bile into the duodenum. Which of the following statements is true?
A.In the initial phase, consistent contraction of the gallbladder force bile through the sphincter of Oddi.
B.All three phases of digestion elicit similar rates of gallbladder empting.
C.Stimulation of sympathetic nerves to the gallbladder inhibits emptying of the gallbladder.
D.During the intestinal phase of digestion contraction and relaxation are mostly mediated by the cholinergic signaling elicited by the vagus nerve and gastrin release from the stomach.
E.None of the above.
C.Stimulation of sympathetic nerves to the gallbladder inhibits emptying of the gallbladder.
True/False
Beta-adrenergic stimulation of salivary glands produces a greater volume of saliva having the same concentration of amylase.
False. lesser volume of saliva
True/False
G-cells of the gastric mucosa release histamine.
False. gastrin.
True/False
If concentrations of peptides and/or amino acids entering the duodenum become high then release of cholecystokinin increases.
False. of gastrin increases.
True/False
Serous acinar cells of the parotid salivary glands produce alpha-amylase.
True
True/False
The family of proteolytic enzymes known as pepsins have their greatest activity in the jejenum.
False. in the stomach.
True/False
The cystic duct joins the common hepatic duct to form the common bile duct.
True
True/False
Cholecystokinin causes the Sphincter of Oddi to contract.
False. to relax.
True/False
An important function of the hepatocytes is to produce and secrete proteins such as albumin, into the canaliculi.
False. ?
True/False
The highest rate of gallbladder emptying is during the gastric phase of eating.
False. intestinal phase
True/False
Most dietary protein is reduced to amino acids and small peptides by pepsins in the stomach.
False. by trypsin in the intestine.
True/False
Release of secretin reduces the secretory activity of parietal and chief cells.
False. and G cells.
True/False
The pancreatic duct is protected from pancreatic enzymes by the action of enteropeptidase produced by duct's epithelial cells.
False. of secretin
True/False
The pancreas is innervated by both the sympathetic and parasympathetic nervous systems.
True
Of which of the following conditions, which one would be associated with melena as a symptom:
a. achalasia
b. hiatus hernia
c. peptic ulcer
d. pedunculated adenoma
e. hemorrhoids
c. peptic ulcer
Concerning the movement of chloride across the membrane of parietal cells, which of the following is NOT true:
a. it crosses the basolateral membranee by countertransport with HCO3-
b. it crosses the basolateral membranee by countertransport with Na+
c. it crosses the apical (luminal) membrane by facilitated diffusion
d. it is transported into the cell against a large electrochemical gradient
e. all of the above are true
b. it crosses the basolateral membranee by countertransport with Na+
When the pH of the material entering the duodenum falls below 3.5, which of the following does NOT happen:
a. reduced contractions of the pyloric region
b. increased contraction of pylorus
c. increased duodenal motility
d. increased release of gastrin
e. all of the above happen
d. increased release of gastrin
Concerning the digestive enzymes produced by the pancreas, which of the following is NOT true:
a. they are important for the digestion of all major classes of food
b. they are transported to the duodenum in a fluid that has a HCO3- concentration that is higher than plasma
c. they are important in the conversion of primary bile acids to secondary bile acids
d. their secretion is stimulated by cholecystokinin and secretin
e. they are secreted as proenzymes
c. they are important in the conversion of primary bile acids to secondary bile acids
(bacteria is important)
Concerning its composition, which of the following is NOT found in saliva:
a. glycoprotein mucins
b. salivary amylase
c. salivary lipase
d. HCO3-
e. lysozymes and IgA
c. salivary lipase
Concerning the liver, which of the following is NOT true:
a. receives nutrient-rich blood from the hepatic portal vein
b. receives nutrient-rich blood from the hepatic artery
c. hepatocytes removes substances from the blood and secrete them into canaliculi
d. arterial blood and hepatic portal venous blood flow in a countercurrent pattern
e. all of the above are true
d. arterial blood and hepatic portal venous blood flow in a countercurrent pattern
True/False
Cholera is usually self-limiting with fluid replacement.
True
True/False
Steatorrhea is the production of a black, tarry, appearing stool.
False. Melena is.
True/False
Fecaliths are associated with the development of diverticular disease.
False. of appendicitis.
True/False
The bacterial disease that causes ulceration of the small intestine and hyperplasia of the systemic reticuloendothelial system (mononuclear phagocytic system) is cholera.
False. is salmonella.
The number-one cause of intestinal obstruction is _______________.
Intestinal Hernia or Hernia
True/False
Intussusception is the most common cause of intestinal obstruction.
False. Hernia is
True/False
The GI disorder caused by Salmonella microbs that produces acute diarrhea, ulceration of the small intestine, systemic reticuloendothelial hyperplasia, and may lead to hemorrhage, bowel perforation, and rupture of the spleen is __________.
Typhoid Fever
True/False
If duodenal pH falls below 3.5, the hormone secretin is released.
True
True/False
The exocrine pancreas play a vital role in digestion as insufficient exocrine pancreas secretion lead to starvation even if the body is consuming adequate quantities of high quality foods.
True
True/False
AQP6 have been identified in zymogen granules in parotid gland and submandibular glands.
False. AQP5 ... parotid gland only.
True/False
When the double mutant mice lacking IP3R2 and IP3R3 were fed a predigested diet containing glucose and amino acids for a week they died. This data suggest that the digestive system dysfunction caused the malnutrition.
False. for a week they gained weight.
True/False
The gastric phase of gastric secretion is mediated by the Vagus nerve and involves distension of the stomach.
True
True/False
Proteases in pancreatic juice in the pancreas are trypsin, chymotrypsin and carboxypeptidase.
False. in the intestine are.
The GI lesion that is associated with the bacterium Helicobacter pylori is ______________.
peptic ulcer
As salivary flow increases:
a. Na+ concentration increases significantly but is more than plasma
b. Cl- concentration decreases significantly but is greater than plasma
c. HCO3 concentration increases significantly but is greater than plasma
d. The tonicity increases, but saliva is hypertonic to plasma
e. K+ decreases slightly, but is lower than plasma
c. HCO3 concentration increases significantly but is greater than plasma
True/False
CCK stimulates gallbladder emptying by causing strong contractions of the gall bladder and relaxation of the sphincter of Oddi.
True
Which of the following is NOT readily absorbed by the gut:

a. fructose
b. glucose
c. amylose
d. galactose
c. amylose
The second (middle) section of the small intestine is the:

a. ileum
b. cecum
c. jejunum
d. duodenum
e. none of the above
c. jejunum
Fecaliths are associated with which of the following:

a. appendicitis
b. diverticular disease
c. cholelithiasis
d. acute cholecystitis
a. appendicitis
The type of smooth muscle activity that serves to knead (mix) the contents of the colon is referred to as:

a. segmentation
b. peristalsis
c. migrating myoelectric complex
d. haustration
e. mass movement
d. haustration
The cell type of the gastric mucosa that is continuously exfoliated is the:

a. tall columnar epithelial cell
b. mucous neck cell
c. parietal cell
d. chief cell
e. G-cell
a. tall columnar epithelial cell
The gastric cells that produce the secretagogue histamine are the:

a. oxyntic cells
b. G cells
c. chief cells
d. enterochromaffin-like cells
d. enterochromaffin-like cells
The type of hepatitis caused by a double-stranded DNA virus consisting of an outer envelope and an inner nucleocapsid (called a Dane particle) is: [from assigned reading]

a. hepatitis A
b. hepatitis B
c. hepatitis C
d. hepatitis D
b. hepatitis B
The infectious agent that produces acute diarrhea, ulceration of the small intestine, and hyperplasia of the mononuclear phagocytic system (reticuloendothelial system) is:

a. Vibrio cholerae
b. Salmonella typhi
c. Salmonella enteritidis
d. Entamoeba histolytica
b. Salmonella typhi
Hydrogen ions serve as a secretagogue for:

a. parietal cells
b. chief cells
c. G cells
d. enterochromaffin-like cells
a. parietal cells
The condition producing chronic or recurrent diarrhea, atrophy of the villi of the small intestine, and is induced by gluten-containing foods is:

a. ulcerative colitis
b. celiac sprue
c. Crohn's Disease
d. diverticular disease
b. celiac sprue
True/False
Gastric contents entering the duodenum have a pH of less than 3.5 result in the release of cholecystokinin.
False. secretin.
True/False
Typhoid fever, caused by Salmonella typhi, can cause hyperplasia of mononuclear phagocytic system and result in rupture of the spleen.
True
True/False
Celiac sprue is induced by gluten-containing foods.
True
True/False
Parasympathetic stimulation of salivary glands produces a greater volume of saliva having the same concentration of amylase.
True
True/False
The pyloric glandular region of the stomach has the highest concentration of parietal and chief cells.
False. The oxyntic glandular region
True/False
The gastric phase of H+ release is mediated entirely by the vagus.
False. The intestinal phase
True/False
Release of the enzyme component of the pancreatic juice, produced by the acinar cells, is stimulated by secretin.
False. by CCK.
True/False
The cystic duct joins the common hepatic duct to form the common bile duct.
True
T/F?
The pepsinogens are converted to their active form by the action of enteropeptidase.
False. by the action of HCl.
T/F?
An increase in intracellular calcium within salivary gland cells results in the production of a greater volume of saliva having the same concentration of amylase.
True
T/F?
The prostaglandins E2 and I2 (PGE2 and PGI2) function to lower cytoplasmic levels of cAMP in parietal cells.
True
T/F?
Intussusception involves twisting of the small intestine and often result in blockage of the intestine.
False. Volvulus
T/F?
The cardiac glandular region of the gastric mucosa contains acid and pepsinogin secreting cells.
False. The oxyntic
T/F?
Villous adenoma is more often associated with development of cancer of the colon than pedunculated adenoma.
True
True/False
Chief or peptic cells produce intrinsic factor.
False. Parietal cells
True/False
Kupffer cells are phagocytic cells.
True
True/False
Bile canaliculi drain into bile ducts located in the center of each hepatic lobule.
False. located in the periphery
True/False
The more lecithin in the bile, the less cholesterol can be dissolved in the micelles.
False. more cholesterol.
True/False
Dietary fiber increases intestinal transit time.
False. decreases
T/F?
The cephalic phase of gastric acid secretion is mediated entirely by the vagus nerve.
True
Which of the following is released in response to peptides and amino acids entering the duodenum?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
b. gastrin
T/F?
The inactive pancreatic proteases chymotrypsinogen and procarboxypeptidase are activated by trypsin.
True
Which of the following is the primary stimulus causing hepatocytes to secrete?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
c. cholecystokinin
T/F?
Digested lipid material reaches the liver for processing via the hepatic artery.
True
Which of the following is released in response to fatty acids and/or monoglycerides entering the duodenum?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
c. cholecystokinin
Which of the following decreases acid secretion by parietal cells?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
a. secretin
Which of the following is the aqueous component of pancreatic juice?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
a. secretin
Which of the following has the highest rate of gallbladder emptying?

a. secretin
b. gastrin
c. cholecystokinin
d. acetylcholine
e. histamine
c. cholecystokinin
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Hydrogen and potassium

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
a. primary active transport
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Bicarb and chloride

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
b. countertransport
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Chloride

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
d. facilitative diffusion
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Sodium and potassium

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
a. primary active transport
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Potassium (alone)

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
d. facilitated diffusion
Match one of the modes of ion transport associated with the parietal cells of the stomach:
Chloride (alone)

a. primary active transport
b. countertransport
c. cotransport
d. facilitated diffusion
e. simple diffusion
d. facilitated diffusion
True/False
Pancreatic enzymes convert primary bile acids into the secondary bile acids.
False. Bacteria convert
True/False
The highest rate of gallbladder emptying occurs during the intestinal phase and is mediated by cholecystokinin.
True
True/False
Inflammation of the gallbladder is referred to as cholelithiasis.
False. cholecystitis
Trypsinogen is converted to trypsin by the action of ________________.
enterokinase.
An ion that has an increased concentation in saliva as secretion rate goes up and has been found to be important in preventing dental caries is _________.
HCO3-
The mucousal cells that are continuously shed (exfoliated) from the inner surface of the stomach is called ________________________.
tall, columnar epithelial
The intitial production of H+ in the parietal cells is greatly accelerated by the enzyme ___________________.
carbonic anhydrase
The concentration of Cl- is (greater in/less in) interstitial fluid than in parietal cells.
less in
The only source of lipases is the _________________.
Pancreatic juice.
The largest gland of the body is the __________.
liver
Vitamin D plays an essential role in the absorption of _____.
Ca++
The correct medical term for excessive amounts of fatty material in the feces is ____________.
steatorrhea
The type of smooth muscle activity that serves to knead the contents of the colon is referred to as:
a. segmentation
b. peristalsis
c. migrating myoelectric complex
d. haustration
e. mass movement
d. haustration
Young children are more prone to develop which of the following conditions:
a. intestinal hernia
b. adbominal adhesions
c. intussusception
d. diverticular disease
c. intussusception
Diverticular disease most frequently produces pain in the ______________ quadrant of the abdomen.
a. upper right
b. lower right
c. upper left
d. lower left
d. lower left
The gastric cells that produce the secretagogue histamine are the:
a. oxyntic cell
b. G cells
c. chief cell
d. enterochromaffin-like cells
d. enterochromaffin-like cells
Which of following is NOT a function of HCl in the stomach:
a. Convert pepsinogen to pepsins
b. Provide an acid environment in which the pepsins are active
c. Protonate carbohydrates to cleave alpha-1,4 glucose linkages
d. kill most ingested organisms
e. all are functions
c. Protonate carbohydrates to cleave alpha-1,4 glucose linkages
The cell type responsible for the production of most blood proteins is the:
a. pancreatic acinar cell
b. Kupffer cell
c. hepatocyte
d. gallbladder cell
c. hepatocyte
Concerning the digestion of carbohydrates, which of the following is NOT true:
a. both salivary amylase and alpha-amylase can only cleave alpha-1, 4 glucose linkages
b. both salivary amylase and alpha-amylase can only cleave carbohydrates to oligosaccharides
c. oligosaccharides are broken down by brush border enzymes
d. glucose and galactose cross brush border membrane by cotransport coupled to sodium
e. all of these statement are true
e. all of these statement are true
The type of carbohydrate that is a linear molecule and has only alpha-1,4 linkage is:
a. amylopectin
b. amylose
c. cellulose
d. glycogen
b. amylose