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7 Cards in this Set
- Front
- Back
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What is Syndrome of Inappropriate ADH (SIADH)?
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increased production/secretion of ADH
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What is the most common cause of Syndrome of Inappropriate ADH (SIADH)?
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independent secretion of ADH from a non-endocrine source
-oat cell (small cell carcinoma of the lung), cancer in duodenun/pancreas, and lymphomas -surgeries are notorious -drugs (chemotherapies, tylenol, thiazide diuretics) |
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What are the clinical manifestations of Syndrome of Inappropriate ADH (SIADH)?
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-hyponatremia (110-115)
-increased r/o seizure -decreased plasma osmolarity from volume expansion -increased levels of ADH -MS changes -urine hyperosmolarity (concentrated) |
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What happens to blood Na+ levels with Syndrome of Inappropriate ADH (SIADH)?
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-decrease in Na+ (hyponatremia) 110-115
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How does RAAS contribute to Syndrome of Inappropriate ADH (SIADH)?
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-volume overload suppresses RAA, which decreases further reabsorption of Na+ from renal tubules
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What is a symptom of sodium imbalance seen with Syndrome of Inappropriate ADH (SIADH)?
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-seizures
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What is the Tx for Syndrome of Inappropriate ADH (SIADH)?
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-hypertonic NaCl for Na+ replacement
-PO fluid restriction to 600-800mL/d -Lasix (diuretic) -Lithium to interfere w/ADH at the kidney level -monitor I&O, urine SG, CV changes, MS |
