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27 Cards in this Set

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34 year old female
difficulty reading and fatigue
pins and needles in left arm, resolved without tx
visual field deficits observed
mild hyperreflexia noted
electrophoresis of csf shows oligoclonal bands
defective myelination of the axons in her CNS
which are the defective cells?
oligodendrocytes
dye injected into lateral ventricles is unable to reach third ventricle. where is the blockage
foramina of monro
type 2 dm
loss of sensation in left leg
thrombotic occulsin off of which branch of artery in the controlateral cerebral hemisphere would cause this?
occlusion of anterior cerebral artery
diplopia worse upon distant vision
inablity to move left eye laterally (abduct)
rest of eye movements are normal
diagnosed with isolated damage to one of the cranial nerves that control eye ball movements
the motor nucleus of the cranial nerve is located where?
cranial nerve 6
pons
pupillary light reaction, which is the preglangionic parasymphathetic neuron that controls the pupillary constriction
edinger westphal nucleus, in the midbrain, in front of the cerebral aqueduct, below the superior colliculus
what are the mechanoreceptors in the epidermosy that sense touch and pressure
merkel cells

meissner corpuslces- position sense, fine touch located in papillary dermis
langerhans cells are dendritic cells in the epidermis
pacinian corpuscles are deep, detect pressure only
end bulbs of krause are in the dermis, detect cold temperature
what are sweat glands innerated by
postganglionic sympathetic cholinergic fibers
car crash
right sided hemiplegia
loss of pain and temp on the left side
ct reveals partial transection of the cervical spinal cord at C5
the transection is likely to have involved which
right lateral half of the spinal cord
this is brown sequard syndrome
1. controlateral loss of pain and temp below the lesion
2. ipsilateral loss of proprioception, vibration below the lesion
ipsilateral upper motor neuron lesion signs below the lesion
lower motor neorn lesion signs at the lesion- flaccid paralysis
the sensory manifestations from the above lesion result from damage to what?
lateral spinothalamic tract
49 Yo female
fatigue, difficulty with speech and swallowing
muscle spasms
occasional constipation/urinary retention
physical exam- slurred speech, defective memory and nystagmus
sensory responses were poor
mri revealed ares of demylination and plaques in the brain stem, basal ganglia and spinal cord
she died ten years later
a stained sextion is likely to show demyelination where?
the opitc nerve
50 year old male, progressive muscle weankness in upper/lower limbs
difficulty iwth speech and swallowing
PE reveals muscle wasting and fasciculations and lowered muscle strenght in all extremities
upper limb reflexes are absent
lower likb reflexes are risk, positive babinskis
cranial nerves are intact, no sensory abnormalities detected
genetic analysis shows mutation for genes that encode superoxide dismutase, what is the dx?
ALS
man had motorcycle accident, lost consciousness immediately
regained consciousness
lost consciousness again in the ER
skull x ray showed a temporal bone fracture, the symptoms are due to bleeding between the
dura mater and the calvarium- epidural hematoma

bleeding between dura and arachnoid is subdural hematoma
recurrent epidosdes of loss of consciousness.falls to ground, then regains consciousness.
what type of seizure is this?
atonic
involuntary twitching of right foot. tonic clonic seizure. where did the seizure originate.
primary motor cortex on the leftside
female. weakness in lower limbs
decreased power in muscles of lower limb on both sides
normal sensory system
csf shows oligoclonal IgG bands
mri of spinal cord shows demyelination at t9-t11 levels
which tract is affected and where is it on the spinal cord
lateral corticospinal tract, for desecind voluntary movement of contralateral limbs. located bilaterally next to dorsal horn in the white mater
recurrent parastheisa, weakness in limbs
temporary blindess in the left eye
speech unnafected
decreased muscle power and spasticity in the left upper and lower limbs. exaggerated deep tendonr eflexes on the left side and extensor planter response in the left toe
cranial nerves are intact except weaknes in the lower lef half of the face. cerebral angiogram would show decreased blood flow where
right internal carotid artery

mca lesion would damage upper limb motor and sensory cortex, wernickes, and brocas
ACA lesion would damage lower limb motor and sensory cortex
internal carotid supplies blood to the MCA ACA and lateral striate arteries
progressive symmetric muscular weakness in upper extremeties.
difficulty speaking and swalling.
spasicity of upper limbs and positive babinski
sensory and mental systems are normal
whats an additional finding?
fasciculations of the muscles of the hand, this is ALS which shows UMN and LMN effects
man has trouble seeing on his right side with either eye.visual acuity is normal. visual field tests shows loss of vision in the right half of the visual fields in both eyes. pupils react to light and accomodate. eye movements are normal. the symptoms of this patient are suggestive of occlusion where?
posterior cerebral artery

if theres occlusion in posterior communicationg artery you'll see cn 3 nerve palsy
woman has sifficulty speaking, chwing and swallowing
has generalized weakness that increases as the day goes on. symptoms improve upon neostigmine admin
the autoantibodies resposnible for this conditon are directed against?
acetocholine receptors, this is myasthenia gravis
headache, tonic clonic seizures
weakness in left leg
weakness in upper left extremity
spastic hemi paresis of the left upper and lower extremities
increased tone and axaggerated deep tendon reflexes with normal muscle bulk in left extremities
cranial nerves are normal
skull x ray reveals an area of hyperosteosis
mri shows meningioma, the tumor is likely located over the?
right precentral cortex

post central cortex- sensory
precentral cortex is motor
prefrontalcortex- orchestrates thoughts and actions
50 plus year old male
headache, fatiuge and fever
intense, constant headaches localized in the temporal regions associated with diplopia, night sweats, fever and polymyalgia
aggrevated by jaw movements.
firm nodular, imccopressible and tender temporal arteries that pulsate poorly
PE was unremarkable
labs show elevated ESR mild anemia and leukocytosis. biopsy of the temporal artery would show?
granulomatous inlfammation of the media with lymphocytic infiltrate and multinucleated giant cells

this is temporal arteritis
chronic alcoholic developed incoordination of gait. confused and disoriented. walked with broad based ataxic gait. severe malnutrition. difficulty performing finger to nose test
an additional physical finding in the patient would be dysmetria
wernickes encephaloptathy charactiized by ocular disturbances (nystagmus and paralysis of lateral rectus muscle), changes in mental state, unsteady stance and gait (cerebeller dysfunction)
korsekoff syndrome- anterograde and retrograde amnesia and one of aphasia, apraxia (can't perform purposful movements), agnosia, or a deficit of executive functions

brain atrophy occurs in thalamus, mamillary bodies and third ventricle, floor of fourth ventricle, cerebellum and the frontal lobe
stuporous man. abnormal movements of the limbs, urinary incontincen. right pupil unresponsive to flash light. fundus showed bilateral papilledema. absent gag reflex. muscle tone and deep tendon reflexes exaggerated. muscle power decreased on left side but normal on right. where is the lesion
brainstem

cn 9 and 3 not working
pyramidal tracts, corticospinal and corticobulbar not working
ataxia
white guy, fleeting movement of extremities. unable to sustain motor activity. personality changes- inattention, poor concentration, depression. low mini mental status exam score. marked rigidity in all extremities, normal sensation. mri shows cerebral atropy and very small caudate nuclei. father died of similar illnes. dna likely to show?
CAG repeats in chr 4- huntingtons dz
hits his head. six hours later loses consciousness. ct scan shows biconvex shaped mass on left side of the scull. rupture of which artery
middle meningial artery
severe headache, sudden onset. elevated blood pressure,depressed breathing and pulse rate. dilaated unresponsive pupils, papilledema. ct scan shows a mass in the right cerebral hemisphere with midline shift. which is the likely cause
cerebral edema with uncal herniation
unconcsious. headache that was worst of his life, in back of his head. wet pants after losing consciousness. no hx of convulsions. hx of ht, and dm. neck stiffness and left pupil dilated and sluggishly reacting to light. what would csf look like
have red blood cells