Pathology

Front 1

name five important components of lymphoreticuloendothelial system

Back 1

lymph nodes, thymus, spleen, tonsils and adenoids, Peyer patches

Front 2

in follicular hyperplasia of a lymph node which structures become prominent

Back 2

Gemrinal centers

Front 3

Burkitt lymphoma is caused by what virus?

Back 3

Epstein-Barr virus

Front 4

The greatest preponderance of non-Hodgkin lymphomas are of

Back 4

B-cell origin

Front 5

the two major histomorphologic patterns seen in follicular lymphomas

Back 5

small cells with irregular or cleaved nuclear contours and scant cytoplasm referred to as centrocytes and larger cells with open nuclear chromatin

Front 6

what are the four catagories of the real classification of lymphoid neoplasms

Back 6

precursor B-cell neoplasms, percursor t-cell neoplasms, peripheral B-cell neoplasms, Peripheral T-cell and natural killer cell neoplasms

Front 7

Burkitt lymphoma has a characterstic histologic appearance which is known as

Back 7

Starry sky pattern

Front 8

the distinctive tumor giant cell found in cases of Hodgkin disease is known as

Back 8

Reed Sternberg cell

Front 9

Reed Sternberg cells have histologic appearance of

Back 9

15-45 micormeters in diameter, binucleate or bilobed with the two halves often appearing as mirror images of each other

Front 10

Lacunar cell

Back 10

varient of Reed Sternberg cell with abudant pale cytoplasm with an empty nucleus

Front 11

Lacunar cell is most frquently encountered with

Back 11

Nodular Sclerosis type Hodkins disease

Front 12

name the four types of Hodgkins disease

Back 12

Nodular Sclerosis, Mixed cellularity, Lymphocyte predominance, Lymphocyte depletion

Front 13

the most common form of Hodgkin disease seen in young adults

Back 13

Nodular Sclerosis

Front 14

Name the three catagories of myeloid neoplasia

Back 14

actue mylogenous leukemia, Myelodysplastic syndromes, Chronic myeloproliferative disorders

Front 15

Acute mylogenous leukemia

Back 15

characterized by accumulation of immature myeloid cells in the bone marrow

Front 16

Myelodysplastic syndromes

Back 16

associated with ineffective hematopoiesis and assocaited cytopenias

Front 17

Chronic myeloproliferative disorders

Back 17

usually associated with an increased production of terminally differentiated myeloid cells

Front 18

what are the three major clinical conditions which give leukemias their ominous prognosis

Back 18

anemia-fatigue, neutropenia-fever, thrombocytopenia-spontaneous mucosal and cutaneous bleeding

Front 19

name the three types of white cells by which leukemias are subclassified

Back 19

myeloblasts, monoblasts, megakaryoblasts

Front 20

what is the most common form of leukemia in children

Back 20

Acute lymphoblastic leukemia

Front 21

what is the most common form of leukemia in adults over the age 60 in the western world

Back 21

Chronic lymphocytic leukemia

Front 22

myelodysplastic syndrome

Back 22

group of clonal stem cell disorders characterized by maturation defects resulting in ineffective hematopoiesis and an increased risk of transformation to AML

Front 23

the most common cytogenetic finding associated with CML

Back 23

translocation involving the BCR gene on chromosome 9 and the ABL gene on chromosome 22-Philadelphia chromosome

Front 24

the most common gross finding in the spleen in patients with Hodgkins disease is

Back 24

splenomegaly

Front 25

Multiple myeloma

Back 25

multiple tumorous masses of neoplastic plasma cells scattered throughout the skeletal system

Front 26

Waldenstrom macroglobulinemia

Back 26

syndrome stemming from serum-hyperviscosity caused by high levels of IgM

Front 27

Primiary or immunocyte-associated amyloidosis

Back 27

results from monoclonal proliferation of plasma cells secreting free light chains that are subsquently processed and depositied as amyloid

Front 28

Monoclonal gammopathy of undetermined significance

Back 28

instances in which M components are identified in the blood of patients having no symptoms or signs of any of the better characterized monoclonal gammopathies

Front 29

Heavy Chain disease

Back 29

seen in diverse group of disorders including CLL and SLL lymphoplasmcytic lymphoma and an unusual small bowel lymphoma occuring in malnourished populations

Front 30

the light chain proteins found in patients with plasma cell dyscrasias are known as

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Bence Jones Proteins

Front 31

Multiple myeloma most frequently involves which organ system

Back 31

Skeletal system

Front 32

radiologically the lesions seen in multiple myeloma are osteolytic or osteoblastic?

Back 32

Osteolytic

Front 33

name the three clinicopathologic entities of Langerhans cell histiocytosis

Back 33

acute disseminated Langerhans cell histiocytosis, unifocal and mutlifocal Langerhans cell histiocytosis, Hand Schuller Christian triad multifocal Langerhans cell histiocytosis

Front 34

describe the histologic components of eosinophilic granuloma

Back 34

histiocytes are variety admixed with eosinphils, lymphocytes, plasma cells and neutrophils

Front 35

describe the component parts of Hand Schuller Christian triad

Back 35

Calvarial defects, diabetes, insipidus, and exophtalmos

Front 36

white pulp

Back 36

forms periarterial sheaths of lymphoid cells around the arteries most abudant about the larger branches and progressively more attenuated as the arterial supply penetrated the splenic substance

Front 37

red pulp

Back 37

trasversed by numerous thin walled vascular sinusoids sperated by the splenic cords(cords of Billroth)

Front 38

name the four major functions of the spleen

Back 38

filtration of unwanted elements from the blood, major secondary organ in the immune system, source of lymphoreticular cells and sometimes hematopoeitic cells, reserve pool and storage site

Front 39

accessory spleens

Back 39

or Spleniculi are common findings

Front 40

describe the gross appearance of splenic infarcts

Back 40

infarcts are characteristically pale and wedge shaped with their bases at the periphery where the capsule is covered with fibrin

Front 41

name the two most commonm benign neoplasms of the spleen

Back 41

lymphangioma and hemangioma

Front 42

name the two types of cancer in which there is splenic involvement

Back 42

Leukemia and lymphoma

Front 43

at what age does thymic involution start

Back 43

puberty

Front 44

what are Hassal corpuscles

Back 44

epithelial cells in the thymus medulla have only scant cytoplasm devoid of interconnecting processes may be spindled with oval darkly staining nuclei