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44 Cards in this Set

  • Front
  • Back
name five important components of lymphoreticuloendothelial system
lymph nodes, thymus, spleen, tonsils and adenoids, Peyer patches
in follicular hyperplasia of a lymph node which structures become prominent
Gemrinal centers
Burkitt lymphoma is caused by what virus?
Epstein-Barr virus
The greatest preponderance of non-Hodgkin lymphomas are of
B-cell origin
the two major histomorphologic patterns seen in follicular lymphomas
small cells with irregular or cleaved nuclear contours and scant cytoplasm referred to as centrocytes and larger cells with open nuclear chromatin
what are the four catagories of the real classification of lymphoid neoplasms
precursor B-cell neoplasms, percursor t-cell neoplasms, peripheral B-cell neoplasms, Peripheral T-cell and natural killer cell neoplasms
Burkitt lymphoma has a characterstic histologic appearance which is known as
Starry sky pattern
the distinctive tumor giant cell found in cases of Hodgkin disease is known as
Reed Sternberg cell
Reed Sternberg cells have histologic appearance of
15-45 micormeters in diameter, binucleate or bilobed with the two halves often appearing as mirror images of each other
Lacunar cell
varient of Reed Sternberg cell with abudant pale cytoplasm with an empty nucleus
Lacunar cell is most frquently encountered with
Nodular Sclerosis type Hodkins disease
name the four types of Hodgkins disease
Nodular Sclerosis, Mixed cellularity, Lymphocyte predominance, Lymphocyte depletion
the most common form of Hodgkin disease seen in young adults
Nodular Sclerosis
Name the three catagories of myeloid neoplasia
actue mylogenous leukemia, Myelodysplastic syndromes, Chronic myeloproliferative disorders
Acute mylogenous leukemia
characterized by accumulation of immature myeloid cells in the bone marrow
Myelodysplastic syndromes
associated with ineffective hematopoiesis and assocaited cytopenias
Chronic myeloproliferative disorders
usually associated with an increased production of terminally differentiated myeloid cells
what are the three major clinical conditions which give leukemias their ominous prognosis
anemia-fatigue, neutropenia-fever, thrombocytopenia-spontaneous mucosal and cutaneous bleeding
name the three types of white cells by which leukemias are subclassified
myeloblasts, monoblasts, megakaryoblasts
what is the most common form of leukemia in children
Acute lymphoblastic leukemia
what is the most common form of leukemia in adults over the age 60 in the western world
Chronic lymphocytic leukemia
myelodysplastic syndrome
group of clonal stem cell disorders characterized by maturation defects resulting in ineffective hematopoiesis and an increased risk of transformation to AML
the most common cytogenetic finding associated with CML
translocation involving the BCR gene on chromosome 9 and the ABL gene on chromosome 22-Philadelphia chromosome
the most common gross finding in the spleen in patients with Hodgkins disease is
Multiple myeloma
multiple tumorous masses of neoplastic plasma cells scattered throughout the skeletal system
Waldenstrom macroglobulinemia
syndrome stemming from serum-hyperviscosity caused by high levels of IgM
Primiary or immunocyte-associated amyloidosis
results from monoclonal proliferation of plasma cells secreting free light chains that are subsquently processed and depositied as amyloid
Monoclonal gammopathy of undetermined significance
instances in which M components are identified in the blood of patients having no symptoms or signs of any of the better characterized monoclonal gammopathies
Heavy Chain disease
seen in diverse group of disorders including CLL and SLL lymphoplasmcytic lymphoma and an unusual small bowel lymphoma occuring in malnourished populations
the light chain proteins found in patients with plasma cell dyscrasias are known as
Bence Jones Proteins
Multiple myeloma most frequently involves which organ system
Skeletal system
radiologically the lesions seen in multiple myeloma are osteolytic or osteoblastic?
name the three clinicopathologic entities of Langerhans cell histiocytosis
acute disseminated Langerhans cell histiocytosis, unifocal and mutlifocal Langerhans cell histiocytosis, Hand Schuller Christian triad multifocal Langerhans cell histiocytosis
describe the histologic components of eosinophilic granuloma
histiocytes are variety admixed with eosinphils, lymphocytes, plasma cells and neutrophils
describe the component parts of Hand Schuller Christian triad
Calvarial defects, diabetes, insipidus, and exophtalmos
white pulp
forms periarterial sheaths of lymphoid cells around the arteries most abudant about the larger branches and progressively more attenuated as the arterial supply penetrated the splenic substance
red pulp
trasversed by numerous thin walled vascular sinusoids sperated by the splenic cords(cords of Billroth)
name the four major functions of the spleen
filtration of unwanted elements from the blood, major secondary organ in the immune system, source of lymphoreticular cells and sometimes hematopoeitic cells, reserve pool and storage site
accessory spleens
or Spleniculi are common findings
describe the gross appearance of splenic infarcts
infarcts are characteristically pale and wedge shaped with their bases at the periphery where the capsule is covered with fibrin
name the two most commonm benign neoplasms of the spleen
lymphangioma and hemangioma
name the two types of cancer in which there is splenic involvement
Leukemia and lymphoma
at what age does thymic involution start
what are Hassal corpuscles
epithelial cells in the thymus medulla have only scant cytoplasm devoid of interconnecting processes may be spindled with oval darkly staining nuclei