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34 Cards in this Set
- Front
- Back
List the antiemetics
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Metoclopramide HCL
Ondansetron HCL Prochlorperazine Promethazine HCL "MOPP up the vomit" |
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Which antiemetics come in generic?
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All:
Metoclopramide Prochlorperazine Ondansetron Promethazine |
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Brand name of Metoclopramide HCL?
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Reglan
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Dosage forms/strs of Metoclopramide HCL?
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Tabs 5/10mg
Syrup 5mg/5ml Injectable 5mg/ml |
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Indications for Metoclopramide HCL?
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Diabetic gastroparesis
Emetogenic cancer chemo N&V prevention GERD Small bowel intubation GI motility stimulant for radiological exam |
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MoA of Metoclopramide?
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Dopamine rx blocker
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DIs with Metoclopramide?
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Alcohol incs drowsiness
Reglan incs action of cyclosporine and succinylcholine Reglan decs serum digoxin level |
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Contras with Metoclopramide?
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Pheochromocytoma
GI hemorrhage GI obstruction or perforation Epilepsy Drugs that cause extrapyramidal rxns Depression Hypertension Parkinsonism |
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AEs of Metoclopramide?
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Restlessness
Drowsiness Tardive Dyskinesia Fatigue |
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Px for Metoclopramide?
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Avoid alcohol and use care when operating machinery
Take 30 mins before meals |
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Brand name of Ondansetron HCL?
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Zofran
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Dosage forms/strs of Ondansetron HCL?
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Tabs, ODT 4/8mg
Oral soln 4mg/5ml Injectable 2mg/ml, 32mg/50ml |
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Indications for Ondansetron HCL?
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N&V prevention (for emetogenic cancer chemo and body irradiation radiotherapy)
N&V prevention post-op |
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MoA of Ondansetron?
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5-HT3 (serotonin) rx blocker
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DIs with Ondansetron?
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No known
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Contras with Ondansetron?
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Hypersensitivity to other 5-HT3 rx blockers
Not a substitute for nasogastric suction Phenylketonurics (chewables contain phenylalanine) |
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AEs of Ondansetron?
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Headache
Fatigue Constipation |
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PxCx for Ondansetron?
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Dont remove chewable tabs from blister pack until use
Dont push chewable tab thru foil |
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Brand name of Prochlorperazine?
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Compazine
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Dosage forms/strs of Prochlorperazine?
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Tabs 5/10mg
Suppositories 25mg Injection 10mg/2ml |
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Indications for Prochlorperazine?
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Psychotic disorder mgmt
Severe N&V Excessive anxiety mgmt |
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MoA of Prochlorperazine?
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Dopamine rx blocker
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DIs with Prochlorperazine?
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Anticholinergics and Barbiturates dec effects of compazine which decs effects of Guanethidine
Alchohol incs CNS depression Compazine + Metrizamide decs seizure threshold |
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Contras with Prochlorperazine?
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Hypersensitivity to phenothiazines
Comatose/greatly depressed Bone marrow depression kids under 2 yrs old or under 20 pds Pediatric surgery Nursing moms Glaucoma Cardiovascular disorders Chemo drugs |
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AEs of Prochlorperazine?
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Drowsiness
Dizzy Amenorrhea Blurred vision Itching Photosensitivity Urticaria Hypotension EXTRAPYRAMIDAL rxns TARDIVE DYSKINESIA |
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Px for Prochlorperazine?
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Avoid alcohol and use care when operating machinery
Avoid overexposure to sunlight or heat Contact dermatitis if injectable contacts skin |
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Brand name of Promethazine?
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Phenergan
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Dosage forms/str of Promethazine?
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Tabs 12.5/25/50mg
Syrup 6.25mg/5ml Suppositories 12.5/25/50mg Injection 25mg/ml, 50mg/ml |
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Indications for Promethazine?
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Motion sickness
N&V Perennial and seasonal allergic rhinitis Vasomotor rhinitis Allergic conjunctivitis Urticaria and angioedema Adjunct to therapy of anaphylactic rxns For sedation |
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MoA of Promethazine?
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Histamine H1 rx blocker
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DIs with Promethazine?
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Anticholinergics and Barbiturates dec effects of phenergan
Alcohol may inc CNS depression Metrizamide may dec seizure threshold |
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Contras with Promethazine?
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Pxs with lower respiratory tract disorders (like asthma)
Pediatrics < 2 yo (possible fatal resp depression) Injection is contra'd with comatose pxs or on high CNS depressants Caution in preg (cat c), children, narrow angle glaucoma, peptic ulcers, impaired liver, and cv disease. |
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AEs of Promethazine?
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N&V
Drowsiness Blurred vision Dry mouth Dizziness Rash |
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Px for Promethazine?
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Can take with food or milk if GI upset
May cause drowsiness, caution when mental alertness req'd Avoid alcohol |