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5 Cards in this Set
- Front
- Back
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Osteoarthritis
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-Affects weight bearing joints
-Pain gets worse with weight bearing exercise -Morning stiffness <30 min -Crepitus, esp. in knee -Joint deformities in shape of nodes and osteophytes on DIP and PIP joints |
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Pathophysiology of OA
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-Inflammatory, biochemical, and immunologic process
-Cartilage becomes thin due to imbalance between proteoglycan breakdown and chondrocyte activity |
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Drug Treatment of OA
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Acetaminophen DOC
If not sufficient, add NSAIDs and opioids Capsaicin Glucosamine/chondroitin Hyaluronic acid |
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Glucosamine/Chondroitin
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Natural part of the cartilage. Glucosamine is substrate for proteoglyca. Chondroitin retains water for shock absorption
Increase effect of warfarin |
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Hyaluronic Acid in OA
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FDA approved for knee pain due to OA
Injection into synovium increases viscosity, enabling normal tissue to regenerate |
