Organic Chemistry 1 (Set 2)

Front 1

Which type of molecules cannot undergo Substitution reactions?

Back 1

Vinylic Cations and Aryl Cations

Front 2

In Sn1, what type of concentration is favored to stabilize charge?

Back 2

high concentrations

Front 3

What type of solvents stabilize charge?

Back 3

Polar Solvents

Front 4

List of Protic Solvents

Back 4

H20, Formic Acid Methanol, ethanol, tert-butyl alcohol, and Acetic Acid

Front 5

Formic Acid

Back 5

HCOOH

Front 6

Methanol

Back 6

MeOH (CH3OH)

Front 7

Ethanol

Back 7

EtOH (CH3CH2OH)

Front 8

Tert-Butyl Alcohol

Back 8

(CH3)3COH (tert-BuOH)

Front 9

Acetic Acid

Back 9

CH3COOH (HoAC)

Front 10

List of Aprotic Solvents

Back 10

Dimethyl Sulfoxide, Acetonitrile, DMF, Benzene, Hexane

Front 11

Dimethyl Sulfoxide

Back 11

DMSO

Front 12

Acetonitrile

Back 12

MeCN

Front 13

In a reaction, if the reactants are charged ________________

Back 13

the reaction slows down as the reaction continues

Front 14

In a reaction, if the intermediate is charged ___________________

Back 14

the reaction speeds up as the reaction continues

Front 15

Sn2 favors high concentrations of _______________

Back 15

aprotic solvents

Front 16

Sn1 favors poor nucelophilies in ____________________

Back 16

protic solvents

Front 17

Intermolecular Reactions

Back 17

reaction between 2 molecules to form one molecule

Front 18

Intramolecular Reactions

Back 18

reaction between one molecule and itself to form a ring structure (prefer 5 & 6)

Front 19

What do elimination reactions produce?

Back 19

alkenes

Front 20

E2 Reaction is a ______________ reaction.

Back 20

concerted (1 step)

Front 21

Do E2 reactions have a transition state or a intermediate?

Back 21

transition state

Front 22

What type of stereochemistry does E2 reactions favor?

Back 22

antiperiplanar

Front 23

Alpha Carbon

Back 23

Carbon attached to the halogen

Front 24

Beta Carbon

Back 24

Carbon adjacent to the alpha carbon

Front 25

Dimethyl Sulfoxide

Back 25

DMSO

Front 26

Do E2 reactions have a transition state or a intermediate?

Back 26

transition state

Front 27

In cyclic systems, eliminated groups prefer to be in what position?

Back 27

axial

Front 28

Acetonitrile

Back 28

MeCN

Front 29

what is also called a Beta-elimination reaction?

Back 29

E2

Front 30

Do E1 reactions have intermediated or transition states?

Back 30

intermediate

Front 31

In a reaction, if the reactants are charged ________________

Back 31

the reaction slows down as the reaction continues

Front 32

In a reaction, if the intermediate is charged ___________________

Back 32

the reaction speeds up as the reaction continues

Front 33

in E1 reactions, the __________ alkene is formed

Back 33

the most stable alkene; carbocation rearrangement can happen

Front 34

In E2 reactions, _________ products are more favored than ___________ products

Back 34

conjugated; isolated

Front 35

Sn2 favors high concentrations of _______________

Back 35

aprotic solvents

Front 36

Sn1 favors poor nucelophilies in ____________________

Back 36

protic solvents

Front 37

Tert-Butoxides always:

Back 37

eliminate

Front 38

In E1 reactions the more ____________ product is usually formed

Back 38

substituated

Front 39

Benzylic and Allylic carbocation stabilities (3, 2, 1 benzylic and allylic)

Back 39

3 Benzylic, 3 allylic, 2 benzylic, 2 allylic, 3 carbocation, 1 benzylic, 1 allylic

Front 40

What do elimination reactions produce?

Back 40

alkenes

Front 41

E2 Reaction is a ______________ reaction.

Back 41

concerted (1 step)

Front 42

In E2 reactions, _________ products are more favored than ___________ products

Back 42

conjugated; isolated

Front 43

Tert-Butoxides always:

Back 43

eliminate

Front 44

What type of nucleophile and solvent do E2 reactions prefer?

Back 44

more basic better nucleophiles; aprotic

Front 45

What type of nucleophile and solvent do E1 reactions prefer?

Back 45

less basic weak nucleophiles; protic

Front 46

Deterium Atom

Back 46

atom with one proton and one neutron

Front 47

Which is more difficult to break, a C-D bond or a C-H Bond?

Back 47

C-D Bond

Front 48

Deuterium Kintetic Isotope Effect

Back 48

Kh/Kd

Front 49

What is the maximum of DKIE? and which constant is slower?

Back 49

The max is 7.1
Kd is slower than Kh

Front 50

Primary Alkyl Halides only undergo:

Back 50

Sn2 and E2 reactions

Front 51

Elimination prefers _____ temp

Back 51

high

Front 52

Substitution prefers ______ temp

Back 52

low

Front 53

Primary carbocations tend to:

Back 53

substitute (Sn1) not eliminate

Front 54

Williamson Ether Synthesis

Back 54

Preparation of an alloxide
R-Br + R-O- ---> ROR + Br-

Front 55

Hindered Nucleophiles in a Williamson Ether Synthesis do what?

Back 55

increase the rate of the reaction

Front 56

How are alkynes prepared? Elimination or Substitution

Back 56

Double Elimination

Front 57

Are alcohols good leaving groups?

Back 57

No, so therefore they must be weakened to undergo substitution

Front 58

In Substitition reactions, alcohols are _______

Back 58

protonated and then replaced with a halogen to react

Front 59

In Sn2 reactions of alcohols, if H-CL is used:

Back 59

then ZnCl2 or Pyridine is needed to make the reation proceed