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13 Cards in this Set
- Front
- Back
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Cancer Toxicities
classifications |
acute or subacute
most common examples: - rapidly dividing cells - mucous membranes - hair, skin, GI tract, bone marrow Chronic and/or cumulative - delayed - nephrotoxicity - neurotoxicity - cardiomyopathy - pulmonary fibrosis - secondary malignancies |
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Cancer
prevention and treatment of chemothearpy-induced n/v (CINV) drugs for highly to moderate CINV |
5-HT3 R antagonists
- these drugs at a minimum for the prevention of acute CINV also consider (Aprepitant) |
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Cancer
prevention and treatment of chemothearpy-induced n/v (CINV) low-risk to unlikely emetogenic regimens |
dexamethasone
a phenothiazine |
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Cancer
prevention and treatment of chemothearpy-induced n/v (CINV) delayed CINV |
> 24 h after admin of chemotx
metocloproamide and dexamethasone are recommended at a minimum |
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what should all pts receiving potentially emetogenic regimens receive wrt CINV?
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1. prophylactic tx for CINV
2. resuce meds for CINV |
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Cancer
goals of tx localized or regional dz |
localized or regional dz
- ie stages I, II, and early III - curative - inhibition of recurrence of dz |
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Cancer
goals of tx advanced or metastiasized dz |
- ie advanced stage III and stage IV
- palliate sx - reduce tunor load - prolong survival - increase qol |
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Cancer
survival and repsonse definitions cure, complete response, partial response, stable dz, progression |
Cure: 5 yrs of cancer-free survival
CR: absence of all neoplastic dz for min of 1 month PR: >50% dec in tumor size or other markers for min of 1 month stable dz: no change or criteria for PR not met progression: >25% inc in tumor size or new lesion |
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Cancer
cell cycle phases (5) |
G0 = resting phase
- no cell division G1 = postmitotic phase - enzymes for DNA syn are made S = DNA synthesis - DNA separation and replication G2 = premitotic phase - specialized proteins and RNA made M = mitosis - actual cell division occurs |
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Cancer
drug tx principles |
chemo has greatest effect on rapidly growing cells
agents can be phase-specific or phase-nonspecific |
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Cancer
treatment priciples neoadjuvant therapy |
tx given prior to primary tx
goal is to shrink the tumor to increase the efficacy of the primary treatment examples - chemo or radiation |
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Cancer
treatment principles adjuvant tx |
additional tx given after main treatment
goal is to make sure all residual dz is gone |
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Cancer
four main treatments |
surgery
radiation chemo biologic tx |
