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28 Cards in this Set

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Nitrogen mustards
Alkylating agents
Non-cell phase specific

Mechlorethamine
Cyclophosphamide (parent compound has no activity)
Ifosfamide
Nitrosureas
Alkylating agents
Non-cell phase specific
Lipophilic (cross BBB) and renally eliminiated

Carmustine (BCNU)
Lomustine (CCNU)
Platinum analogues
Alkylating agents
Non-cell phase specific

Cisplatin
Carboplatin
Oxaliplatin
Folate antagonists
Antimetabolites
S-phase specific

Methotrexate
Pemetrexed
Purine analogues
Antimetabolites
S-phase specific

Mercaptopurine
Fludarabine
Cladribine
Pyrimidine analogues
Antimetabolites
S-phase specific

Flourouracil (5-FU)
Cytarabine (ara-C)
Capecitabine - metabolized to 5-FU
Vinca alkaloids
Antimicrotubule
M-phase specific - disassemble microtubules

Vincristine
Vinblastine
Vinorelbine
Taxanes
Antimicrotubule
M-phase specific - assemble and freeze microtubules

Paclitaxel
Docetaxel
Topo-I inhibitors
S-phase specific

Irinotecan (CPT-11)
Topotecan
Topo-II inhibitors
S-phase specific

Etoposide (VP-16)
teniposide
Anthracyclines
Antitumor antibiotic
Non-cell phase specific

Daunorubicin
Doxorubicin
Idarubicin
Epirubicin
Mitoxantrone
Other antitumor antibiotics
Bleomycin
Dactinomycin
Mitomycin
Which advanced malignancies can be cured with chemotherapy?
Acute Lymphocytic Leukemia in children only
Acute myeloid leukemia
Testicular Cancer
Hodgkin's Disease
Non-Hodgkin's Lymphoma
Small cell lung cancer (limited stage)
Which malignancies can be treated with chemotherapy with "curative intent"?
Breast cancer (Early stage)
Colorectal cancer (Advanced stages)
Osteosarcoma
Ovarian cancer
Which advanced cancers can have survival prolonged with chemotherapy?
Breast Cancer
Bladder Cancer
Multiple myeloma
Head and neck cancer
Pancreatic cancer
Prostate cancer
Non-small cell lung cancer
What is the combination regimen for NHL?
CHOP - Cyclophosphamide, Hydroxy-daunarubicin, Oncovin (vincristine), Prednisone
What is the combination regimen for Hodgkin's disease?
ABVD - Adriamycin, Bleomycin, Vinblastine, Dacarbazine
What is the combination regimen for breast cancer?
CAF - Cyclophosphamide, Adriamycin, Fluorouracil
What is the combination regimen for lung cancer?
EP - Etoposide, Cisplatin
What is the combination regimen for sarcoma?
MAID - Mesna, Adriamycin, Ifosfamide, Dacarbazine
Complete response
No evidence of tumor
Partial response
At least 50% reduction in tumor size
Disease progression
Tumor progresses at original site or moves to another site.
Stable disease
Less than 25% change in tumor size (increase or decrease)
Chemoprotectant: Mesna (Mesnex)
indicated to decrease hemorrhagic cystitis caused by cyclophosphamide and iphosphamide. Mesna binds to the destructive metabolite
Chemoprotectant: Dexrazoxane (Zinecard)
cardioprotectant, protects from anthrocyclines. Free oxygen radicals damage the myocardium leading to heart failure; this drug scavanges the radicals.
Chemoprotectant: Amifostine (Ethyol)
triol to prevent nephroxicity w/ cysplatin. Can cause hypotension and severe N/V. Also used for radiation to reduce SE.
Chemoprotectant: Leucovorin
methotrexate inhibits dihydrofolate reductase, leading to myelosuppression & mucositis. Leucovorin rescues normal cells.