Oncology

Front 1

Nitrogen mustards

Back 1

Alkylating agents
Non-cell phase specific

Mechlorethamine
Cyclophosphamide (parent compound has no activity)
Ifosfamide

Front 2

Nitrosureas

Back 2

Alkylating agents
Non-cell phase specific
Lipophilic (cross BBB) and renally eliminiated

Carmustine (BCNU)
Lomustine (CCNU)

Front 3

Platinum analogues

Back 3

Alkylating agents
Non-cell phase specific

Cisplatin
Carboplatin
Oxaliplatin

Front 4

Folate antagonists

Back 4

Antimetabolites
S-phase specific

Methotrexate
Pemetrexed

Front 5

Purine analogues

Back 5

Antimetabolites
S-phase specific

Mercaptopurine
Fludarabine
Cladribine

Front 6

Pyrimidine analogues

Back 6

Antimetabolites
S-phase specific

Flourouracil (5-FU)
Cytarabine (ara-C)
Capecitabine - metabolized to 5-FU

Front 7

Vinca alkaloids

Back 7

Antimicrotubule
M-phase specific - disassemble microtubules

Vincristine
Vinblastine
Vinorelbine

Front 8

Taxanes

Back 8

Antimicrotubule
M-phase specific - assemble and freeze microtubules

Paclitaxel
Docetaxel

Front 9

Topo-I inhibitors

Back 9

S-phase specific

Irinotecan (CPT-11)
Topotecan

Front 10

Topo-II inhibitors

Back 10

S-phase specific

Etoposide (VP-16)
teniposide

Front 11

Anthracyclines

Back 11

Antitumor antibiotic
Non-cell phase specific

Daunorubicin
Doxorubicin
Idarubicin
Epirubicin
Mitoxantrone

Front 12

Other antitumor antibiotics

Back 12

Bleomycin
Dactinomycin
Mitomycin

Front 13

Which advanced malignancies can be cured with chemotherapy?

Back 13

Acute Lymphocytic Leukemia in children only
Acute myeloid leukemia
Testicular Cancer
Hodgkin's Disease
Non-Hodgkin's Lymphoma
Small cell lung cancer (limited stage)

Front 14

Which malignancies can be treated with chemotherapy with "curative intent"?

Back 14

Breast cancer (Early stage)
Colorectal cancer (Advanced stages)
Osteosarcoma
Ovarian cancer

Front 15

Which advanced cancers can have survival prolonged with chemotherapy?

Back 15

Breast Cancer
Bladder Cancer
Multiple myeloma
Head and neck cancer
Pancreatic cancer
Prostate cancer
Non-small cell lung cancer

Front 16

What is the combination regimen for NHL?

Back 16

CHOP - Cyclophosphamide, Hydroxy-daunarubicin, Oncovin (vincristine), Prednisone

Front 17

What is the combination regimen for Hodgkin's disease?

Back 17

ABVD - Adriamycin, Bleomycin, Vinblastine, Dacarbazine

Front 18

What is the combination regimen for breast cancer?

Back 18

CAF - Cyclophosphamide, Adriamycin, Fluorouracil

Front 19

What is the combination regimen for lung cancer?

Back 19

EP - Etoposide, Cisplatin

Front 20

What is the combination regimen for sarcoma?

Back 20

MAID - Mesna, Adriamycin, Ifosfamide, Dacarbazine

Front 21

Complete response

Back 21

No evidence of tumor

Front 22

Partial response

Back 22

At least 50% reduction in tumor size

Front 23

Disease progression

Back 23

Tumor progresses at original site or moves to another site.

Front 24

Stable disease

Back 24

Less than 25% change in tumor size (increase or decrease)

Front 25

Chemoprotectant: Mesna (Mesnex)

Back 25

indicated to decrease hemorrhagic cystitis caused by cyclophosphamide and iphosphamide. Mesna binds to the destructive metabolite

Front 26

Chemoprotectant: Dexrazoxane (Zinecard)

Back 26

cardioprotectant, protects from anthrocyclines. Free oxygen radicals damage the myocardium leading to heart failure; this drug scavanges the radicals.

Front 27

Chemoprotectant: Amifostine (Ethyol)

Back 27

triol to prevent nephroxicity w/ cysplatin. Can cause hypotension and severe N/V. Also used for radiation to reduce SE.

Front 28

Chemoprotectant: Leucovorin

Back 28

methotrexate inhibits dihydrofolate reductase, leading to myelosuppression & mucositis. Leucovorin rescues normal cells.