Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/60

Click to flip

60 Cards in this Set

  • Front
  • Back
methotrexate mechanism
- S-phase specific antimetabolite
- folic acid analog that inhigits DHFR -> decreased dTMP -> decreased DNA and protein synthesis
methotrexate clinical use
- leukemia, lymohoma, choriocarconima, sarcomas
- abortion, actopic pregnancy, rhemuatoid arthritis, psoriasis
methotrexate toxicity
- myelosuppression, reversibe w/ leucovorin (folinic acid) rescue
- macrovasicular fatty change in liver
5-FU mechanism
- S-phase specific antimetabolite
- pyrimidine analog bioactivated to 5F-dUMP
- covalently complexes folic acid which inhibits thymidylate synthase -> decrease dTMP
5-FU use
leukemias, lymphomas (not CLL or hodgkins)
5-FU toxicity
- BM, GI, liver
- metabolized to xanthine oxidase, so toxicity icreases w/ allopurinol
busulfan - everything
- alkylates DNA
- used for CML
- can cause pulmonar fibrosis or hyperpigmentation
Cytrabine - everything
- inhibits DNA polymerase
- used for AML
- can cause leukopenia, thrombocytopenia, and megaloblastic anemia
Cyclophosphamide, ifosfamide mechanism
- alkylating agent
- covalently link interstand DNA at G N-7
- requires bioactivation by the liver
Cyclophosphamide, ifosfamide use
- NH lymphoma, breast and ovarian carcinomas
- acts as immunosuppressent
Cyclophosphamide, ifosfamide toxicity
- myelosuppression
- hemorrhagic cystitis which can be prevented w/ mensa
Nitosurases types
carmustine, lomustine, semustine, streptozocin
Nitosurases mechanism
- alkylates DNA
- requires bioactivation
- can cross BBB
Nitosurases use
brain tumors (including glioblastona multiform)
Nitosurases toxicity
CNS
Cisplatian, carboplatin mechanism
- alkylating agents
Cisplatian, carboplatin use
testicular, bladder, ovary, and lung carcinomas
Cisplatian, carboplatin toxicity
nephrotoxicity an acoustic nerve damage
doxorubicin (adriamycin) mechanism
- noncovalently intercalates in DNA
- creates breaks in CNA strands to decrease replication
- generated free radicals
doxorubicin (adriamycin) use
- part of ABVD combo regimin for hodgkins
- for myelomas, sarcomas, and solid tumors (breast, lung, ovary)
doxorubicin (adriamycin) toxicity
- cardiotoxicity
- myelosuppression and marked alopecia
- toxic sctravasation
bleomycin, dactinomycin mechanism
formation of free radicals which can brek DNA
bleomycin, dactinomycin use
testicular cancer and lymphomas
bleomycin, dactinomycin toxicity
- pulmonary fibrosis
- skin changes
- minimal myelosuppression (bleomycin)
etopside mechanism
G2-phase agent that inhibits topoisomerase II adn increases DNA degradation
etopside use
- oat cell carcinomas of the lung
- prostate, testicular cancer
etopside toxicity
- myelosuppression
- GI irritation
- alopecia
prednisone mechanism
- may trigger apoptosis
- may even work on nondividing cells
prednisone use
- most commonly used glucocorticoid in chemo
- CLL, hodgkins (part of MOPP)
- immunosuppressant
prednisone toxicity
- cushing-like syndrome
- immunosup, cataracts, acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, pshcyosis
Tamoxifen, raloxifene mechamism
- estrogen receptor mixed agonist/antoagonist
- blocks the binding of estrogen to estrogen receptor positive cells
Tamoxifen, raloxifene use
breast cancer, good to prevent osteoporosis
Tamoxivfn, raloxifene toxicity
- may increase risk of endometial carcinoma
- hot flashes
trastuzumab (herceptin) mechanism
- momoclonal Ab against HER-2 (erb_B2)
- helps kill breast cnacer cells that overexpress it (Ab dependent cytotoxicity)
trastuzumab (herceptin) use
metastatic breast cancer
trastuzumab (herceptin) toxicity
cardiotoxicity
vincristine, vinblastine mechanism
- M-phase alkaloid
- binds tubulin to block poly of microtubules
- mitotic spindle cant form
vincristine, vinblastine use
- lymphoma (MOPP) "Oncovin"
- wilms' tumor
- choriocarcinoma
vincristine, vinblastine toxicity
- vincristine has neurotoxicity, paralytic ileus
- vinBLASTin basts BM
paclitaxel mechanism
- M-phase
- binds tubulin to hyperstabilize poly of microtubules
- mitotic spindle cannot break down (no anaphase)
paclitaxel use
ovarian and breast carcinoma
paclitaxel toxicity
myelosuppression and hypersensitivity
drugs that interfere w/ nuclutide synthesis to DNA
- methotrexate
- 5-FU
- 6-MP
drugs that interfere w/ DNA to mRNA
- alkylating agents and cisplatin - cross linkage
- dactomycin and doxorubicin - intercalte strands
- bleomycin
- etopside - strand breaks
- steriods
- tamoxifen
drugs that interfere w/ protein
- vinca alkyloids - inhibit mucrotubule formation
- paclitaxel - inhibitmicrotubule disassembly
drugs that get the M pahse
vinca alkaloids and taxols
drugs that get the G2 pahse
bleomycin
podophyllotoxins
drugs that get the S pahse
podophyllotoxins
antimetabolites
cell cycle specific
- antimetabolites
- plant alkyloids
- steroid hormones
- bleomycin
- paxlataxel
- etoposide
cell cycle nonspecific
- alkylating agents
- antibiotics
paclitaxel use
ovarian and breast carcinoma
paclitaxel toxicity
myelosuppression and hypersensitivity
drugs that interfere w/ nuclutide synthesis to DNA
- methotrexate
- 5-FU
- 6-MP
drugs that interfere w/ DNA to mRNA
- alkylating agents and cisplatin - cross linkage
- dactomycin and doxorubicin - intercalte strands
- bleomycin
- etopside - strand breaks
- steriods
- tamoxifen
drugs that interfere w/ protein
- vinca alkyloids - inhibit mucrotubule formation
- paclitaxel - inhibitmicrotubule disassembly
drugs that get the M pahse
vinca alkaloids and taxols
drugs that get the G2 pahse
bleomycin
podophyllotoxins
drugs that get the S pahse
podophyllotoxins
antimetabolites
cell cycle specific
- antimetabolites
- plant alkyloids
- steroid hormones
- bleomycin
- paxlataxel
- etoposide
cell cycle nonspecific
- alkylating agents
- antibiotics