Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
Sibutramine |
Mechanism: Blocks serotonin and noradrenaline reuptake at the hypothalamic site, may alter NPY and POMC levels, as well as possibly increasing leptin transport into the brain during weight loss. Leads to an increase in satiety and reduction in appetite. |
|
|
Rimonabant |
Mechanism: Cannabinoid 1 receptor antagonist, receptor responsible for 'munchies' Effectively reduced body weight, however suspended due to increased incidents of suicidal behaviour. |
|
|
Orlistat |
Mechanism: Prevents the uptake of fats via inhibiting lipase, which breaks down fats in the diet to fatty acids and allows absorption into small intestine. -Fat is passed into faeces Adverse Effects: abdominal cramps, flatulence, oily spotting. |
|
|
Topirimate |
Mechanism: several mechanisms unknown -FDA approved for epilepsy and migraine prevention Used in combination with Phentermine |
|
|
Phentermine |
Mechanism: Increases the release of noradrenaline, stimulates B-adrenergic receptors. -Inhibits appetite |
|
|
Bupropion |
Mechanism: Dopamine and noradrenaline uptake inhibitor, effects on POMC signalling -Used as an antidepressant |
|
|
Naltrexone |
Mechanism: Thought to act synergistically with bupropion to release POMC neurons from the inhibitory feedback mechanism that limits their activity. -Long acting opioid receptor antagonist
Used to treat alcohol and opioid dependences |
|
|
Liraglutide |
Mechanism: Glucagon-like peptide 1 receptor (GLP-1R) agonist, mechanisms for actions of GLP-1R agonists appear to overlop with those activated by PYY. -Suppresses appetite -Drug for type 2 diabetes -Decreases gastric emptying |
