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11 Cards in this Set
- Front
- Back
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What state does leptin signal? |
Low leptin: Produced by body fat, the more fat the more leptin. When leptin is low the body thinks it has to little fat - in starvation mode. Thus low leptin is making people eat more |
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Where is leptin produced |
Body fat |
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Leptin and fertility |
Low leptin decreases fertility This can be when you have very low body fat because are starving yourself (anorexic) or exercise a lot (athlete) Body needs certain fat percentage to feed a baby and low leptin signals low fat state and thus shut down fertility |
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Leptin and immunity |
Low leptin reduce immunity? |
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2 types Info body needs about nutrition status |
1. Fat mass - how long last without food 2. Food recently eaten - short term signals from stomach and gut |
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Hormones released during / after meal that signal what |
Macronutrients eaten How many calories |
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What body part is a fuel sensor |
Hypothalamus |
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Pathway in hypothalamus that regulate food intake How does it function |
Leptin-melancortin pathway: Sense fat and controls appetite Leptin reflects fat circulating in blood and signals to leptin receptor on POMC neurons in hypothalamus. Leads to release of pomc fragments called melancortjn peptides. These signal to some Neurons that express MC4R that influence food intake. |
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Is gene mutation in MC4R (defiency) gene causing obesity common? |
No, 1% of obese has it |
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Food preference with defect melancort pathway |
Prefer high fat food but not sweet |
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Key issue with melancortim pathway |
Defective MC4R protein that responds suboptimal to melancortin pathway |
