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7 Cards in this Set
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- 3rd side (hint)
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Serum sickness |
Type III hypersensitivity immune reaction, in which antigen-antibody complexes form and lodge in small vessels which lead to inflammation, tissue damage, and necrosis |
Occurs occasionally after administration of penicillin or sulfonamide |
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Signs & symptoms of serum sickness |
Occurs 7-days to 3 weeks after exposure, most predominant severe urticaria & angioedema. Less severe: fever, malaise, muscle soreness, arthralgia, splenomegaly, nausea& vomiting |
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Diagnostic tests for serum sickness |
Slightly elevated wbc count, sedimentation rate, C-reactive protein. IgG & IgM immunoglobulin increase substantially, complement assay decrease. Plasma cells are seen on peripheral blood smear |
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Therapeutic measure |
Self-limiting 10 days, antipyretics/fever, analgesics & anti-inflammatories/athralgia, antihistamines/urticaria& angioedema, corticosteroids if symptoms persist |
Serum sickness |
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Interventions |
Monitor pain using (0-10) pain scale, provide analgesics as ordered for pain, monitor input & output |
Serum sickness |
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Hashimotos thyrioditis |
Enlargement of thyroid due to overstimulation (hyperthyroidism), autoantibodies destroy thyroid cells, which slows secretion then causing hypothyroidism |
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Causes of hashimoto |
8 times more in females than males, common age group (30-50) |
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