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Serum sickness
Type III hypersensitivity immune reaction, in which antigen-antibody complexes form and lodge in small vessels which lead to inflammation, tissue damage, and necrosis
Occurs occasionally after administration of penicillin or sulfonamide
Signs & symptoms of serum sickness
Occurs 7-days to 3 weeks after exposure, most predominant severe urticaria & angioedema. Less severe: fever, malaise, muscle soreness, arthralgia, splenomegaly, nausea& vomiting
Diagnostic tests for serum sickness
Slightly elevated wbc count, sedimentation rate, C-reactive protein. IgG & IgM immunoglobulin increase substantially, complement assay decrease. Plasma cells are seen on peripheral blood smear
Therapeutic measure
Self-limiting 10 days, antipyretics/fever, analgesics & anti-inflammatories/athralgia, antihistamines/urticaria& angioedema, corticosteroids if symptoms persist
Interventions
Monitor pain using (0-10) pain scale, provide analgesics as ordered for pain, monitor input & output
Hashimotos thyrioditis
Enlargement of thyroid due to overstimulation (hyperthyroidism), autoantibodies destroy thyroid cells, which slows secretion then causing hypothyroidism
Causes of hashimoto
8 times more in females than males, common age group (30-50)
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