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14 Cards in this Set
- Front
- Back
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NSAID's
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Anti-inflammatory drugs
Reduces symptoms of inflammation including; pain, fever, loss of function, redness and swelling. Analgesic, antipyretic |
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Rheumatism
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General term for any of several disorders characterized by inflammation, degeneration, or metabolic derangement of connective tissue
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NSAID's uses
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Inflammation reduction, fever reduction, mild to moderate pain relief
arthritis, rheumatism, myalgia, neuralgia, and arthralgia, gout, hyperuricemia. |
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Acetylsalicyclic acid
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Aka: Aspirin
Same effects as other NSAIDs Adverse effects are GI intolerance, bleeding, renal impairment, |
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Arachidonic pathways
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Inhibits Prostaglandins (PG's) or Leukotriene (LT) pathways both which lead to inflammatory responses.
By inhibiting these pathways inflammation is reversed. |
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Antipyretic: reduces fever
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Inhibits prostaglandin E2 by inhibiting biosynthesis of within preoptic-hypothalamic are of the brain that controls temperature
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Gout
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Treated with NSAIDs
Inappropriate uric acid metabolism (underexcreation or overproduction) Uric acid crystals are deposited in tissued and joints causing pain |
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Allopurinol (Zyloprim)
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Used to reduce production of uric acid
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Colchine
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Reduces inflammatory responses to the deposits of urate crystals in the joints
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Probenecid (Benemid) and Sulfinpyrazone (Anturane)
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Increases the excretion of uric acid in the urine
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NSAID's (Adverse Effects)
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GI problems: Dyspepsia, heartburn, epigastric nausea, GI bleeds, mucosal lesions
Renal: Reduction in creatinine clearance, acute tubular necrosis with renal failure Cardiovascular: Noncardiogenic pulmonary edema |
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NSAID (Toxicity)
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Adults: Tinnitus, hearing loss
Children: hyperventilation and CNS effects, reyes syndrome Metabolic acidosis and respiratory alkalosis |
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NSAIDs (Interactions)
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Anticoagulants
Aspirin Corticosteroids and ulcer drugs Protein bound drugs |
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Antirheumatoid Arthritis Drugs (Disease-modifying antirheumatic drugs, DMARDs)
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Slow onset (several weeks)
3-6 months before full effects are seen Much more toxic than NSAIDs Anti-inflammatory, antiarthritic, immunomodulating effects Ex: auranofin, aurothioglucose, gold sodium thiomalate, leflunomide |
