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8 Cards in this Set

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MOA of NSAIDs
bind to cyclooxygenase to block synthesis of prostaglandins

*some MAY have LOX activity as well, but of minor importance
What alterations in the patient do NSAIDs treat?
pain, inflammation, endotoxemia, fever, hypercoaguability
What is the pathway for producing prostaglandins
PLA2 liberates arachidonic acid from membranes
arachidonic acid metabolized by COX to form prostaglandins
*COX competes with LOX, which forms leukotrienes
List the major ADEs expected with NSAIDs, and state why they are expected
GI upset, ulcers/erosions, nephrotoxicity

"good" prostaglandins are in the stomach and kidney, and their protective function is eliminated by NSAIDs
What is the difference between COX 1 and COX 2?
COX 1 tends to be constitutively expressed
COX 2 tends to have more proinflammatory effects
*most NSAIDs have activity at both, just a matter of how much at each
What legal issues are associated with NSAIDs?
phenylbutazone is illegal in mature dairy cows
Flunixin is the only NSAID approved for use in food animals
Withdrawl times vary widely by species, cannot extrapolate WT or doses
Which NSAIDs are not labeled for veterinary use?
aspirin, ibuprofen, naproxen, flurbiprofen, ketoprofen (allowed in horses)
Which NSAIDs have special uses?
flurbiprofen is only used in opthalmic preparations (approved for humans, but used in animals)
piroxicam is more commonly used in transitional cell carcinoma than as an NSAID