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13 Cards in this Set
- Front
- Back
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Eicosanoids |
Prostaglandins Thromboxanes Leukotrines |
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Phospholipase A2 |
Converts phospholipids in plasma membrane into arachidonic acid |
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PGE2 |
Increases thermostatic set point in hypothalamus - induces fever |
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2 actions of cyclooxygenase |
1. Endoperoxidase synthase action 2. Peroxidase action
Converts arachidonic acid to prostaglandin H2 |
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COX 1 |
Maintains tissue homeostasis Housekeeping enzyme Narrow binding pocket |
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COX 2 |
Induced by inflammation, mediates inflammation Wide binding pocket |
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NSAIDs general action |
Inhibits COX, mostly endoperoxidase synthase activity Inhibits AA --> PGG2 |
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Salicylates (aspirin) |
Inhibits COX 1 preferentially Protein bound serum albumin Effects are dose dependent
Side effect: GI bleeding
Contraindications: displaces warfarin |
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Paracetamol |
Possible COX 1/2 inhibition Mild analgesic Weak antipyretic Weak anti-inflammatory
Side effects: saturates liver enzymes, CYP450 used instead creating toxic NAPQI
Contraindications: anti-epileptics |
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Ibuprofen |
Inhibits COX 1+2 Anti-inflammatory Antipyretic Analgesic Vasodilation
Side effects: mild
Contraindications: asthma (bronchoconstriction) |
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Meloxicam |
Selective COX 2 inhibitor Neuroblastoma treatment Neuropsychiatric disorders |
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Celecoxib |
Selective COX 2 inhibitor Neuroblastoma treatment Neuropsychiatric disorders |
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Cortisol |
Anti-inflammatory actions Stimulates production of Annexin 1 (lipocortin) which blocks PLA2 |
