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19 Cards in this Set
- Front
- Back
Name 8 other side-effects are associated with acetyl-salicylate?
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1) Anorexia
2) Vomiting 3) Hemorrhage 4) GI ulceration 5) Nephrotoxicity 6) Hepatotoxicity 7) Blood dyserasia 8) Hypersensitivity |
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Name 10 drugs that are classified as NSAIDS.
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1) Acetyl-salicylate (aspirin)
2) Acetominophen 3) Phenylbutazone 4) Carprofen 5) Flunixin (banamine) 6) Ketoprofen 7) Naproxen (alleve) 8) Piroxicam 9) Carbolic Acids (etodolac) 10) Miloxicam |
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What is the mechanism for acetominophen?
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centrally active
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What are the 2 secondary effects of NSAIDS, in general?
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1) Antithrombotic: bind COX-1 in platelets, inhibiting TXA2 and clotting
2) Renal vasodilation by closing of efferent arterioles/opening of afferents |
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What is the indication for acetominophen?
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pain relief ONLY
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What 2 AMDE aspects that are related to NSAIDS, in general?
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1) HUGE variation in T1/2 of elimination among species and among individuals within species
2) HIGHLY PROTEIN BOUND (phase I and II) |
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What are the 7 contraindications associated with acetyl-salicylate?
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1) Gastric ulcers (w/ glucocorticoids)
2) Anticoagulants (compete for protein binding sites) 3) Renal/hepatic disease 4) Late pregnancy 5) GI ulcers 6) Dehydration 7) Inhibit excretion (w/ Digoxin) |
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What are the 4 primary effects that NSAIDS produce, in general?
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1) Decrease eicosanoids (thromboxane, prostacycline, prostaglandins)
2) Inhibit pain centrally 3) Decrease peripheral "pain threshold" 4) Decrease fever (decrease PGE) |
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What is the primary effect of acetominophen?
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inhibits pain centrally
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What are the 2 mechanisms used by acetyl-salicylate?
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1) Acetylates irreversibly bind COX-1
2) Affect opiate receptors (CNS) |
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Name 8 other effects of NSAIDS, in general.
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1) Anorexia
2) Vomiting 3) Hemorrhage 4) GI ulceration 5) Nephrotoxicity 6) Hepatotoxicity 7) Blood dyserasia 8) Hypersensitivity |
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Name 7 contraindications for NSAIDS, in general.
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1) Gastric ulcers (w/ glucocorticoids)
2) Anticoagulants (compete for protein binding sites) 3) Renal/hepatic disease 4) Late pregnancy 5) GI ulcers 6) Dehydration 7) Inhibit excretion (w/ Digoxin) |
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What are the 4 indications of NSAIDS, in general?
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1) Reduce inflammation (eg arthritis, fever)
2)Reduce pain (eg colic) 3)Prevent pain (eg perioperative) 4) Prevent endotoxic shock |
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What are 3 indications for acetyl-salicylate?
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1) Reduce inflammation
2) Reduce pain 3) Inhibit clotting |
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What are the 4 primary effects of acetyl-salicylate?
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1) Decrease eicosanoids (thromboxane, prostacycline, prostaglandins)
2) Inhibit pain centrally 3) Decrease peripheral "pain threshold" 4) Decrease fever (decrease PGE) |
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What is the relationship of COX-1 and -2 with regards to NSAIDS, in general?
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COX-2:COX-1 should be <1
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What are the 3 mechanisms used by NSAIDS, in general?
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1) Inhibit cyclo-oxygenase I or II
2) Affect opiate receptors (CNS) 3) Variations on these themes |
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Name the AMDE associated with acetyl-salicylate.
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Very long T1/2 in CAT
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What are the 2 secondary effects of acetyl-salicylate?
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1) Antithrombotic: bind COX-1 in platelets, inhibiting TXA2 and clotting
2) Renal vasodilation by closing of efferent arterioles/opening of afferents |