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76 Cards in this Set

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What drug converts plasminogen to plasmin which degrades the fibrin found in clots?

Alteplase


"t-PA" "Activate"

(Indication) What drug manages high cholesterol (hypercholesterolemia) and is the primary prevention of cardiovascular disease?

Atorvastatin


"Lipitor"

What is the therapeutic class of Atorvastatin (Lipitor)?

Lipid-lowering agent

What is the indication for use of Alteplase (t-PA/Activase)?

MI, acute ischaemic stroke, occluded central lines

What is the therapeutic class and pharmacological class of Alteplase?

Therapeutic class: thrombolytics


Pharmacological class: plasminogen activators

What are two important nursing considerations of Alteplase?

-Monitor patient closely for bleeding (petechiae) q 15min X1hr, q 15-30min X8hr


-Assess neuro status during therapy

What is the action of Atorvastatin?

Lowers total cholesterol as well as LDL while slightly increasing HDL.


Inhibits HMG-CoA reductase which plays a role in the liver in cholesterol formation.

Trade name for Acetaminophen?

Tylenol

Indication for Acetaminophen (Tylenol)?

Pain or fever

Action of Acetaminophen (Tylenol)?

Inhibits synthesis of prostaglandins which play a role in transmission of pain signals and fever response.

Therapeutic class of Acetaminophen (Tylenol)?

Antipyretic, non-opioid analgesic

Antidote for Acetaminophen (Tylenol)?

Acetadote

Do not exceed ______g of acetaminophen per day to limit risk of liver, renal, and cardiac damage.

4g

(Indication) What drug could you give for genital herpes, herpes zoster, and chicken pox?

Acyclovir (Zovirax)

Action of acyclovir (Zovirax)?

Interferes with viral DNA synthesis.

Therapeutic class and pharmacologic class of acyclovir (Zovirax)?

Therapeutic class: Antiviral


Pharmacological class: purine analogues

What drug may cause seizures, renal failure, Stevens-Johnson syndrome, thrombotic thrombocytopenic purpura syndrome, diarrhea, dizziness, nausea?

Acyclovir (Zovirax)

Indication for albuterol (Proventil)?

Bronchodilator used to prevent airway obstruction in asthma and COPD.

Action of albuterol (Proventil)?

Binds to Beta2 adrenergic receptors in the airway leading to relaxation of the smooth muscles in the airways.

Therapeutic class and pharmacologic class of albuterol (Proventil)?

Therapeutic class: bronchodilator


Pharmacologic class: Adrenergic

True or false: Albuterol (Proventil) may decrease the effectiveness of Beta Blockers.

TRUE

Use this bronchodilator drug with caution when patient has heart disease, diabetes, glaucoma, or a seizure disorder.

Albuterol (Proventil)

Indication for alendronate (Fosamax)?

Osteoporosis (aging, menopause, corticosteroid induced)

Action of alendronate (Fosamax)?

Inhibits osteoclast activity.

Important nursing consideration for alendronate (Fosamax)?

Take first thing in the morning with a full glass of water 30 minutes prior to eating.

(Indication) What drug could be used for anxiety, panic dosorder, symptoms of PMS, insomnia, mania, or psychosis?

Alprazolam (Xanax)

What drug works in the CNS to produce anxiolytic effects cause CNS depression?

Alprazolam (Xanax)

Two medications similar to atorvastatin (Lipitor)?

Simvistatin (Zocor)


Rosuvastatin (Crestor)

What drug should you monitor serum cholesterol before, about 4wks after starting, and frequently during therapy?

Atorvastatin (Lipitor)

T/F: Acetaminophen (Tylenol) may decrease risk for bleed with warfarin therapy?

False

Therapeutic and pharmacological class of alendronate (Fosamax)?

Therapeutic class: Bone resorption inhibitor


Pharmacological class: Biphosphnates

Therapeutic and pharmacological class of alprazolam (Xanax)?

Therapeutic class: antianxiety agent


Pharmacological class: Benzodiazepine

What drug should you use caution with when the patient has existing CNS depression, sleep apnea, renal dysfunction, or hepatic dysfunction?

Alprazolam (Xanax)

Antidote for alprazolam (Xanax)?

Romazicon (lumazenil)

Indication for amiodarone (Cordarone)?

A-fib, ventricular arrhythmias, SVT, ACLS protocol for v-fib and v-tach

What drug prolongs phase 3 of the action potential, makes the heart more tolerant to arrhythmias, inhibits adrenergic stimulation, slows rate, decreases peripheral vascular resistance causing vasodilation?

Amiodarone (Cordarone)

Therapeutic classes of amiodarone (cordarone)?

Antiarrhythmic class all, potassium channel blocker

What are some important nursing considerations for amiodarone (Cordarone)?

-increases risk for QT prolongation


-avoid drinking grapefruit juice


-may lead to ARDS, pulmonary toxicity, CHF, bradycardia, hypotention

Indication for amitryptiline (Elavil)?

Depression, anxiety, insomnia, Parkinson's

Action of amitryptiline (Elavil)?

Increases effect of serotonin and norepinephrine in the CNS, exhibits anticholinergic effects

Therapeutic and pharmacologic classes of Amitryptiline (Elavil)?

Therapeutic class: Antidepressant


Pharmacologic class: tricyclic antidepressant

Contradictions of Amitryptiline (Elavil)?

MI, heart failure, QT prolongation, glaucoma. Also, do not use within 2 weeks of MAOIs.

Trade name for Amlodipine

Norvasc

Indication for Amlodipine (Norvasc)?

Hypertension, angina

Action of Amlodipine (Norvasc)?

Blocks transport of calcium into muscle cells inhibiting excitation and contraction.

Therapeutic and pharmacologic classes of Amlodipine (Norvasc)?

Therapeutic class: antihypertensive


Pharmacologic class: Ca channel blocker

Important nursing considerations of Amlodipine (Norvasc)?

-May cause gingival hyperplasia


-Assess characteristics of angina


-Monitor BP and pulse prior to and during therapy

Trade name of Amoxicillin?

Moxatag

Indication of Amoxicillin (Moxatag)?

Skin infections, respiratory infections, sinusitis, endocarditis prophylaxis, Lyme disease

Action of Amoxicillin (Moxatag)?

Inhibits synthesis of bacterial cell wall leading to cell death.

Therapeutic and pharmacologic class of Amoxicillin (Moxatag)?

Therapeutic class: anti-infectives, antiulcer agent


Pharmacologic class: aminopenicillins

Important nursing considerations for Amoxicillin (Moxatag)?

-monitor patient for diarrhea, bloody stool should be reported immediately


-contradicted with penicillin allergy


-may cause seizures

Trade name of ampicillin?

Principen

Indication for ampicillin (Principen)?

Skin infections, soft tissue infections, otitis media, sinusitis, respiratory infections, genitourinary infections, meningitis, septicemia

Action of ampicillin (Principen)?

Bactericidal, broader spectrum than penicillin, binds to call wall leading to bacterial cell death

Therapeutic and pharmacologic class of ampicillin (Principen)?

Therapeutic class: anti-infective


Pharmacologic class: aminopenicillin

Important nursing considerations of ampicillin (Principen)?

-Contraindicated in penicillin allergy


-Use caution in renal insufficiency


-May lead to seizures, diarrhea, anaphylaxis, super infection


-Should not use with oral contraceptive

Another name for acetylsalicylic acid?

Asprin

Indication for Asprin.

Rheumatoid arthritis, osteoarthritis, ischemic stroke, MI prophylaxis

Action of Aspirin

Inhibits the production of prostaglandins which leads to a reduction of fever and inflammation, decreases platelet aggregation leading to a decrease in ischemic diseases

Therapeutic and pharmacologic class of Aspirin?

Therapeutic class: antipyretics, non-opioid analgesics


Pharmacologic class: salicylates

Important nursing considerations for Aspirin?

-Use caution in bleeding disorders and chronic alcohol use


-may lead to Stevens-Johnson syndrome, laryngeal edema and anaphylaxis


-Increases bleed risk w/ warfarin, heparin, and clopidogrel

Trade name for atenolol?

Tenormin

Indication for atenolol (Tenormin)?

Hypertension, angina, prevention of MI

Action of atenolol (Tenormin)?

Blocks the stimulation of beta1 receptors in the SNS with minimal effect on beta2 receptors

Therapeutic and pharmacologic classes of atenolol (Tenormin)?

Therapeutic class: antianginal, antihypertensive


Pharmacologic class: beta blocker

Important nursing considerations for atenolol (Tenormin)?

-Contraindicated in CHF, pulmonary edema, cardiogenic shock, bradycardia, heart block


-May cause bradycardia, CHF, pulmonary edema


-Monitor hemodynamic parameters (HR, BP)

Indication for atropine?

Decreases oral and respiratory secretions, treats sinus bradycardia and heart block, treatment of bronchospasm

Action of atropine?

Atropine is an anticholinergic which means that it inhibits the effects of the parasympathetic nervous system, specifically acetylcholine. This inhibition causes increase in HR, bronchodilation, decreased GI and respiratory secretions.

Therapeutic and pharmacologic classes of atropine?

Therapeutic class: antiarrhythmic


Pharmacologic class: anticholinergic, antimuscarinic

Important nursing considerations for atropine?

-Avoid in acute hemorrhage, tachycardia, and angle closure glaucoma


-Monitor patient for tachycardia and palpitations


-Patients may experience constipation

Trade name for azithromycin?

Zithromax

Indication for azithromycin (Zithromax)?

URI, chronic bronchitis, lower respiratory infections, otitis media, skin infections, various STIs, prevention of bacterial endocarditis, treatment of cystic fibrosis

Action of azithromycin (Zithromax)?

Inhibits bacterial protein synthesis

Therapeutic and pharmacologic classes of azithromycin (Zithromax)?

Therapeutic class: agents for atypical mycobacterium, anti-infectives


Pharmacologic class: Macrolide

Important nursing considerations for azithromycin (Zithromax)?

-May lead to pseudomembranous colitis, pain, diarrhea, nausea, SJS, angioedema


-May increase risk of warfarin toxicity


-Instruct patient to notify physician for diarrhea, or blood or pus in stool