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19 Cards in this Set
- Front
- Back
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What are characteristics of HSCs?
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Ability to differentiate into all hematopoietic lineages
Ability to maintain self renewal |
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What are the types of stem cells? what are the restrictions?
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Embryonic- pluripotent
Adult- multipotent adult progenitor Bone marrow- hematopoietic, bone marrow stromal cells, multipotent |
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Where does hematopoiesis occur in the fetus? Adults?
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Fetus: AGM; yolk sac; liver; spleen; lymph nodes
Adult: bone marrow |
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What are the two methods to sample bone marrow?
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Biopsy
Aspirate |
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What are the steps of myeloid maturation?
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Myeloblast
Promyelocyte Myelocyte Metamyelocyte Band cell Mature neutrophil/ eosinophil/ basophil |
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What does a myeloblast look like?
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Round nucleus with loose chromatin
Blue cytoplasm with no granules |
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What does a promyelocyte look like?
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Round nucleus with loose chromatin
blue cytoplasm with primary granules |
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What does a myelocyte look like?
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Flattened nucleus
Primary granules and secondary |
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What does a metamyelocyte look like?
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Indented nucleus with clumping chromatin
Pink cytoplasm with granules |
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What does a band cell look like?
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Far indented nucleus with clumped chromatin
Many secondary granules |
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How long is the life cycle of a granulocyte?
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14 days to mature; 8 hours in the bloodstream; 2 days in the connective tissue.
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What does a monocyte look like?
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Variable shaped nucleus
Light cytoplasm with vacuoles |
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What do mast cells look like?
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Round nucleus
Packed with dark blue granules Hypersensitivity |
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What do lymphocytes look like?
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round nucleus
Small amount of cytoplasm |
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What do reactive lymphocytes look like?
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Irregular nucleus
Increased cytoplasm with projections- associated with mono |
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What does a plasma cell look like?
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Round nucleus with coarse chromatin
Blue cytoplasm with pale area near nucleus |
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What do megakaryocytes look like?
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2-16 lobed nucleus
Blue/ pink cytoplasm Platelets break off and are released into the blood |
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When would a bone marrow biopsy be indicated?
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Abnormal CBC
Evaluate for possible malignancy Infection, fibrosis, metabolic storage disorders |
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How is a bone marrow transplant done?
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..
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