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11 Cards in this Set
- Front
- Back
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Naltrexone
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Used in Tx of Opioid Addiction
u Opioid Receptor Antagonist -Blocks actions of drugs at u-opioid receptor in VTA -blocks drugs' ability to increase DA levels -Competitive antagonist -->taking more of a drug can overcome affects |
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Clonidine
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-Used to treat Opioid withdrawl
-a2 receptor agonist -suppresses autonomic hyperactivity |
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Methadone
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-Agonist
-Promotes tolerance to drug effects Negative Affects -Transfer of addiction -May require lifetime Tx -Termination may precipitate withdrawl |
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Acamprosate
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Glutamate receptor antagonist
-May block craving of drug |
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Disulfiram
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Used in Tx of alcohol addiction
-Prevents breakdown of acetylaldehyde -Causes acute toxicity in body -Makes you feel awful -Patient compliance may be low |
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Bupropion
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Anticraving Tx for Tobacco
Inhibits uptake of MAO Decreases DA levels Reduces nicotine craving |
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Alcohol
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Action
-Hyperpolarizes GABA release on DA neurons -Increases DA release Withdrawl -Hyperexcitable state -Can last for up to 1 week Treatment -Long lasting sedative (Diazepam) -Benozodiazepine (alcholics have higher abuse potential though) Relapse Prevention Aversion Therapy (Disulfiram) Antagonist (Naltrexone) Anticraving (Acamprosate) |
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Stimulant - Tobacoo
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Stimulates central nicotinic receptors
-Can increase DA levels in the nucleus acumbens -May inhibit MAO Detox -Tx of withdrawl symptoms -Nicotine replacement therapy Relapse Prevention -Agonist (Nicotine rplcment) -Agonist/Antagonist (Better approach) -Anticraving (Bupropion) |
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Alcohol
Mechanism of Action |
Hyperpolarizes GABA neuron
-Increases DA in nucleus acumbens -Increases amount of endogenous opioids |
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Alcohol
Withdrawl Symptoms |
Anxiety, Insomnia, Hyperthermia, DTs=acute pyschosis
-Can last up to 1 week and can be fatal |
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Alcohol Addiction Tx
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Long acting sedative (ie. Diazepam)
-Benzos are not so good b/c they are often abused by alcoholics -Relapse Prevention +Aversion (Disulfiram) +Antagonist (Naltrexone) +Anticraving (Acamprosate) |
