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17 Cards in this Set
- Front
- Back
Which of the antidepressants are MOST likely to produce weight gain?
**EXAM** |
**Tricyclic antidepressants**
Amitriptyline Chomipramine Desipramine Imipramine Nortriptyline |
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Which of the antidepressants are LEAST likely to produce weight gain?
**EXAM** |
***Bupropion**
(atypical antidepressant) -Less likely to cause weight gain (and sexual dysfunction) |
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Which of the antidepressants are most likely to produce nausea and diarrhea?
**EXAM** |
**SSRIs**
(stimulation of 5HT3 receptors) • Citalopram • Fluoxetine • Paroxetine • Fluvoxamine • Sertraline • Escitalopram |
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Which of the antideppressants would most likely cause sexual dysfunction?
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SSRIs
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Which of the antidepressants would most likely cause orthostatic hypotension?
**EXAM** |
Tricyclic Antidepressants
(d/t blocking α1’s) (MAOIs are also very likely to cause orthostatic hypotension) |
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Which of the antidepressants causes the most sedation?
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Tricyclic Antidepressants
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Which antidepressant would cause the least weightgain, least sedation, and least sexual dysfunction?
**EXAM** |
***Bupropion**
(atypical antidepressant) |
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Considering antidepressant classes of drugs, which is the most likely to produce pharmacokinetic interactions because of inhibition of CYP450?
**EXAM** |
**SSRIs**
**DRUG INTERACTIONS** -FLUOXETINE causes more drug interactions than other SSRIs and mostly pharmacokinetic interactions** - Know that SSRIs INHIBIT drug metabolism** - SSRIs = MOST LIKELY antidepressant Rx to cause a Rx-Rx interaction** |
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Which SSRI causes the most drug interactions?
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Fluoxetine
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Which of the SSRIs are the biggest problem regarding increased anxiety and motor restlessness?
**EXAM** |
Fluoxetine and Sertraline are worse of the bunch!***
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Which of the antidepressants have the greatest degree of antimuscarinic effects?
**EXAM** |
TCAs = **Prominent anticholinergic activity**
**amitriptyline is the worst** |
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Which TCA has the worst antimuscarinic effects?
**** |
amitriptyline
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Which of the antidepressants is most frequently used to manage insomnia?
**EXAM** |
Trazadone!!!
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Which of the SSRIs takes the longest to clear from the body (including metabolites)?
**EXAM** |
**Fluoxetine and sertraline**
-metabolized to active metabolites with long half-lives • Fluoxetine metabolite (~180 hours) • Sertraline metabolite (~ 80 hours) NOTE: Because of long t½ of fluoxetine, it has to be **discontinued one month before starting an MAOI** to avoid possible serotonin syndrome |
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What is the basic MOA for anti-depressants?
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Antidepressants increase levels of NE, 5HT
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Name 2 "Atypical" antidepressants
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Bupropion (Welbutrin)
trazodone (Desyrel) |
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Risk of seizures limits the use of which atypical antidepressant?
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Bupropion
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