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39 Cards in this Set

  • Front
  • Back
What is the anterior boundary of the hypothalamus?
Anterior: Lamina terminalis
What is the posterior boundary of the hypothalamus?
Posterior: Vertical drawn at the level of the posterior perforated
Substance
What is the superior boundary of the hypothalamus?
superior: Hypothalamic sulcus separating it from the thalamus
What are the structures which form the floor of the hypothalamus?
Optic chiasma
Tuber cinereum
Infundibulum
Mamillary bodies
Posterior perforated substance
What is the speciality of medial Preoptic nuclei?
Releases GnRH
What is the importance of lateral Preoptic nuclei?
The lateral preoptic nucleus has neurons which release GABA and they help to induce sleep by inhibiting histaminergic neurons.
What are the hormones released by the nuclei of Supraoptic region?
Oxytocin and ADH
Where the hypothalamihypophyseal Portal system does begin?
Hypothalamus
Where the hypothalamophypophyseal portal system terminates?
Anterior Pituitary
Where the releasing hormones enter the portal system?
Fucking Hypothalamus
What is the function of ventromedial nucleus and what happens if there is a lesion to it?
It is the satiety center. Lesion results in Hyperphagia
What is the function of the lateral nucleus and what happens if there is a lesion to it?
It is the Feeding (Makes you eat) center. Lesion results in aphagia starvation.
What happens if there is bilateral lesion to Supraoptic region?
Diabetes Insipidus
What is the only area which releases the histamine in the brain?
histaminergic tuberomammillary nucleus (TMN)
What happens when there is a lesion of the ventromedial nucleus?
Lesions of ventromedial nucleus results in hypothalamic hyperphagia
Orexin is released from which nucleus of the hypothalamus?
Lateral Hypothalamus
Where is Ob receptors situated? What is the effect of leptin on hypothalamic hormones?
Ventromedial nucleus of hypothalamus. Leptin stimulates the production of alpha MSH in the arcuate nucleus which in turn reduces the appetite and increases the ACTH and FSH
The decreased level of leptin stimulates the Neuropeptide Y in the arcuate nucleus and increases the appetite and decreases the secretion of ACTH and FSH
What happens when the posterior part of the hypothalamus is cut? And when it is used clinically?
Bilateral lesions of posterior hypothalamus usually cause poikilothermia, in which the body temperature varies with the environment. The posterior medial hypothalamus is referred to as the region responsible for the control of blood pressure and also aggressive emotional response. Therefore surgical lesions of posteromedial hypothalamus help control malignant blood pressure and rage and violent forms of behavior.
What is circadian rhythm and which nucleus is responsible for this?
Suprachiasmatic nucleus of hypothalamus is involved in the circadian rhythm and synchronizes the light-dark cycle
What is poikilothermia and which part of thalamus is involved in this?
poikilothermia, in which the body temperature varies with the environment. The posterior medial hypothalamus is referred to as the region responsible for the control of blood pressure and also aggressive emotional response
Which neurotransmitter prevents the release of prolactin and where is it released?
Prolactin secretion of the anterior pituitary is inhibited by the dopamine.
Bromocriptine the dopamine agonist is used in prolactin tumors (prolactinoma)
What is the agonist of dopamine that is used in Prolactinoma?
bromocryptine
In which syndrome the Mamillary body is involved?
Wernicke Korsakoff syndrome
Which part of the hypothalamus is surgically cut in controlling violent behavior of psychiatric patient?
Posterior
What is the biochemical effect of increased level of leptin?
Leptin up appetite down
Which drug is used in narcolepsy?
Orexins
What is the effect of Orexin on histamine release?
Orexin stimulates the secretion of histamine and in turn increase in the level of other neurotransmitters responsible for keeping awake
Where is antirise center of temperature in the hypothalamus?
Anterior Hypothalamus
Where is antidrop center of temperature in the hypothalamus?
Posterior Hypothalamus
Name the nuclei which are magnocellular?
They are in the M pathway in vision
Name the neurotransmitter which is inhibitory in the hypophyseal portal system?
Dopamine
Which nucleus acts like switch of non-REM sleep? And what it its neurotransmitter?
The GABAergic neurons of ventrolateral preoptic area are called the non-REM-on cells. GABA
What palsy results when there is bilateral lesion to the genu of the internal capsule and what are its signs?
Pseudobulbar palsy
What happens when the posterior limb of internal capsule has a lesion?
involvement of posterior limb of internal capsule results in the contralateral hemiplegia
What are the ascending tracts that are present in the posterior limb of internal capsule?
Thalamocortical fibers from VPL nucleus  postcentral gyrus of parietal lobe
What is the blood supply of the superior part of the internal capsule?
The superior part is supplied by the lateral striate branches of middle cerebral artery
What is the blood supply of the inferior part of the anterior limb and genu of internal capsule?
The inferior part is supplied by the medial striate branches of anterior cerebral artery
What is the blood supply of the inferior part of the posterior limb of internal capsule?
Inferior part is supplied by the anterior choroidal artery
What are the afferent and efferent tracts traversing the posterior limb of internal capsule?
Afferent fibers;Thalamocortical fibers from VPL nucleus  postcentral gyrus of parietal lobe
Efferent fibers:
Corticospinal fibers which supply the opposite half of the body and they are arranged in the following order.
The head fibers are close to genu and lower limb fibers are most posterior