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40 Cards in this Set
- Front
- Back
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What neurons will release ACh and to which receptors?
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Preganglionic and Postganglionic to nicotinic and muscarinic receptors, respectively
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What is the order of the cascade once ACh comes in contact with a M3?
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NT-->G protein-->Phospholipase C-->IP3-->Ca++
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How does the M3 on trigone (sphinctoer) cause relaxation?
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Stimulates NO formation
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Cholinergic receptors
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ACh can interact with both nicotinic and muscarinic
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When ACh interacts with a nicotinic receptor, what channel is involved?
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Na
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When ACh interacts with a muscarinic receptor what is the receptor cascade involved?
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G-protein
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Bethanecol
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MR agonist
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Atropine
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MR antagonist
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Neostigmine
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anticholinesterase (Myasthenia Gravis)
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Acetylcholine binding proteins
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alpha
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What are ganglionic nicotinic receptors typically composed of?
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2 alpha and 3 beta proteins
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M1,M3, M5 couple to what, doing what?
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Couple to Phospholipase C (stimulating the MR)
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M2 and M4 couple to what, doing what?
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Couple to adenylyl cyclase (inhibiting the MR)
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Augment peristalsis with?
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Bethanecol or neostigmine
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Contract urinary bladder with?
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Bethanecol or neostigmine
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Promote an erection with?
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Sildenafil (Viagra)
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How does sildenafil work?
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Preserves cGMP
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Prevent urination caused by an overactive bladder with?
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Tolterodine
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Muscarinic antagonist
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Tolterodine
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What is the purpose of the apha receptors on the nicotinic receptor?
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ACh binding; activates phospholipase C (Contracts smooth muscle)
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What is the purpose of the beta 2 receptor on the nicotinic receptor?
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activate adenyly cyclase (RELAX smooth muscle) and to promote glycogenolysis
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B2 agonist
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Albuterol
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Nonselective B antagonist
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Propranolol
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Alpha 1 agonist
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Phenylephrine
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Alpha 1 antagonist
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Terazosin
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Can prevent urination with agents potentiating the sympathetic nervous system
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Imipramine
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What stimulates postjunctional receptors?
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Norepi or epi
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What degrades NE?
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Monoamine oxidase
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How is NE reaccumulated in the synapse?
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Axoplasmic pump
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What drug blocks the axoplasmic pump?
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Imipramine (prevent smooth muscle contraction
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2 ways to contract urinary bladder
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Muscarinic agonists or anticholinesterases (Bethanecol or neostigmine)
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How does Tolterodine prevent urination?
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Blocks Muscarinic receptors
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How does Impiramine prevent urination?
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Stimulates sympathetic nervous system
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What are alpha 1 receptor blockers in the sympathetic nervous system used for?
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To ease urination in benign prostatic hyperplasia
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Terazosin
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Alpha 1 receptor blocker to ease urination in BPH
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Doxazosin
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alpha 1 blocker to ease urination in BPH
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Tamsulosin
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alpha 1 blocker to ease urination in BPH
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Tadalafil
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Induce erection (Cialis)
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What do Tadalafil and Sildenafil block?
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Phosphodiesterase 5 which prevents degradation of cGMP
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Physiologically, what causes erections?
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NO
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