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28 Cards in this Set
- Front
- Back
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Maintain the sensitivity of the pain receptors
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PG
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Fibers within the neospinothalamic tract
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A-delta fibers
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What do you tx a sharp, well defined focused pain of the neospinothalamic tract with A-delta fibers?
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COX inhibitors
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Fibers within the paleospinothalamic tract
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C-fibers
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What do you tx a dull, persistent ache, burning, less well defined pain of the paleospinothalamic tract with C fibers?
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Opiods
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caused by nervous system dysfunction rather than stimulation of intact afferent nerve endings
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neuropathic pain
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Related to a defect in the NMDA receptor
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Neuropathic pain
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Name some meds to tx neuropathic pain
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Gabapentin, Carbamaxepine, SNRIs, Tricyclic antidepressants
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Product of COX conversion to AA
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PG
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COX involved in homeostasis
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COX-1 (ubiquitous)
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COX that causes pain, fever and inflammation
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COX-2
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How does aspirin produce an anti-inflammatory effect?
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maintains capillary wall integrity (reduces edema); inhibits release of chemokines, stabilizes lysosome protease release, inhibits formation of free radicals
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Aspirin OD would cause respiratory what?
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Alkalosis
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How does aspirin function as an anti-pyuretic?
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inhibition of interleukin-1
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How does aspirin function as an anticoagulant?
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decreased adhesiveness of platelets
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Where is aspirin absorbed?
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Part in stomach, most in small intestine due to larger surface area
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Where is aspirin excreted?
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Glomerular filtration and tubular secretion
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Alkalization of the urine would do what to the absorption of aspirin?
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Prevent reabsorption (more drug in the ionized form)
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Increasing the urine volume would do what to absorption of aspirin?
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Reduce
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GI problems of aspirin are due to what?
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Inhibition of COX-1
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Phase 1 of aspirin OD is what?
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Respiratory Alkalosis (Hyperventalation)
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Phase 2 of aspirin OD is what?
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Respiratory Acidosis (hypoventilation)
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What would the tx be for an aspirin OD?
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Activated charcoal and alkalinize by giving bicarbonate (HCO3-)
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Where does acetaminophen inhibit cyclogenases?
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In the brain NOT in the peripheral tissues
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What is the most common drug taken in overdose?
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Acetaminophen
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What makes acetaminophen toxic?
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Toxic intermediate (NAPQI)
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What inactivates NAPQI?
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Glutathione
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What is the specific tx to > glutathione
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Cysteine or Cysteamine
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