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8 Cards in this Set
- Front
- Back
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Specific or Non-specific? Synaptic plasticity - definition Effects (EPSP or IPSP) of neurotransmitter depends on what |
Specific Synaptic plasticity - neurons may secrete more than 1 neurotransmitter It depends on the receptors on the postsynaptic cell |
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Neurotransmitters, list (2) |
Ach - CNS, ANS, stimulates skeletal muscle inactivated by cholinesterase (ACHe) Biogenic Amines - modified amino acids |
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Biogenic Amines (4), List |
Catecholamines - from tyrosine (dopamine, epinephrine & norepineephrine) Serotonin - from tryptophan Amino Acids Neuropeptides |
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Pharmacology, Change. . . (5) |
Change . . . Synthesis Release Removal Receptor site Permeability or membrane |
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Catecholamines - Eliminated by: Destroyed by: (2 specific types) |
from tyrosine Eliminated by reuptake into synaptic end bulb Destroyed by COMT and MAO Dopamine - in brain, cocaine = uptake of dopamine increasing stimulation of certain regions of brain causing 'high' Epinephrine & norepinephrine - CNS, ANS, general arousal |
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Serotonin Eliminated by: SSRI Involved in . . . |
From tryptophan Eliminated by reuptake into synaptic end bulb Selective Serotonin Reuptake Inhibitors Involved in sleep, mood regulation (prozac blocks uptake) |
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Amino Acids, List (4) |
GABA- most common in brain, inhibitory Glycine - inhibitory Aspartate Glutamate - excitotoxicity in strokes |
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Neuropeptides What do neuromodulators do? Examples of neuromodulators |
polypeptides neuromodulators modify the effects of neurotransmitters Ex: substance P - pain transmission Ex: endorphins, enkephalins - reduce pain transmission |
