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54 Cards in this Set
- Front
- Back
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abn growth w/ loss of cellular orientation, shape, and size
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dysplasia
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abn cells lacking differentiation
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anaplasia
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clonal proliferation that is uncontrolled + excessive
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neoplasia
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fibrous tissue formation in response to neoplasm
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desmoplasia
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grade
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degree of differentation based on histo
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stage
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degree of localization/spread
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TNM staging system
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tumor size, nodal involvement, mets
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carcinoma = what origin
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epithelial
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sarcoma = what orgin
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sarcoma
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carcinoma stains
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cytokeratin
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sarcoma stains
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vimentin
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muscle tumors stain
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desmin
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4 cancers w/ psammoma bodies
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papillary thyroid, serous cystadenocarcinoma, meningioma, mesothelioma
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top cancer incidence in M
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prostate, lung, colorectal
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top cancer mortality in M
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lung, prostate, colorectal, pancreas
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top cancer incidence in F
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breast, lung, colorectal
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top cancer mortality in F
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lung, breast, colorectal, pancreas
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Mets to brain
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lung, breast, skin, kidney, GI
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Mets to liver
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colon, stomach, pancreas, breast, lung
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mets to bone
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prostate, thyroid, testes, breast, lung, kidney
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downs
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ALL, AML
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xeroderma pigmentosum, albinism
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melanoma, basal cell, esp SCC
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tuberous sclerosis
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cardiac rhabdomyoma, astrocytoma, angiomyolipoma
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actinic keratosis
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SCC skin
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plummer vinson
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SCC esophagus
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paget's bone
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secondary osteosarcoma, fibrosarcoma
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immunodeficiency states
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malignant lymphomas
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ADIS
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aggressive malignant lymphomas, Kaposi's
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autoimmune (Hashimoto's, myasthenia gravis)
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lymphoma
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acanthosis nigricans
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visceral malignancy (stomach, lung, breast, uterus)
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radiation exposure
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sarcoma, papillary thyroid
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Sjrogen's
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B cell lymphoma
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ataxia telangiectasias
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lymphomas, acute leukemias
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CEA
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colorectal, pancreas
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AFP
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HCC, choriocarcinoma
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hCG
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hydatiform moles, chorio
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CA 125
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ovarian, peritoneal irritation
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S 100
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melanoma, astrocytoma
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bombesin
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neuoblastoma, gastric, lung
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Ca 19 9
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pancreas
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abl
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CML
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c-myc
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Burkitt's lymphoma
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bcl-2
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follicular lymphoma
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erb-B2
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breast, ovarian, gastric
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ras
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colon
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L myc
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lung
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N myc
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neuroblastoma
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ret
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MEN Iia, Iib
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c-kit
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GI stromal tumor
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Rb
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retinoblastoma, osteosarcoma
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p16
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melanoma
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Rb gene blocks
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G1 --> S
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p53 gene blocks
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G1 --> S
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BRCA1, 2 are
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DNA repair proteins
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