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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What is the best-known trade name for succinylcholine?
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Anectine
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Suxamethonium chloride, also known as suxamethonium or succinylcholine, is also sold under the trade names Quelicin and Scoline.
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What is the functional class of succinylcholine?
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Depolarizing neuromuscular blocker
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The only other depolarizing neuromuscular blocker used in medicine -- and very rarely -- is decamethonium (Syncurine).
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What is the mechanism of action of succinylcholine?
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Synthetic, ultra short-acting neuromuscular blocking agent. Succinylcholine is composed of two adjacent acetylcholine molecules and has a high affinity for acetylcholine receptors. It causes transient muscle contractions called fasciculations followed by skeletal muscle paralysis. There is no effect on level of
consciousness. |
Succinylcholine was originally known as diacetylcholine because of its structure.
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What are the listed indications for succinylcholine?
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To facilitate endotracheal intubation.
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Neuromuscular blocks are also in surgery, especially during intra-abdominal and intra-thoracic surgeries, to allow them to be conducted with fewer complications.
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What are the listed contraindications for succinylcholine?
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- Acute narrow angle glaucoma
- Penetrating eye injuries - Family history of malignant hyperthermia - Hyperkalemia - 24 - 48 hours post severe trauma including burns - Disorder of pseudocholinesterase - Neuromuscular disorders such as myasthenia gravis or ALS |
ALS is amyotrophic lateral sclerosis, also referred to as Lou Gehrig's disease
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What are the listed precautions for succinylcholine?
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Never paralyze without adequate sedation.
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Patients are still aware of pain even after full conduction block has occurred hence general anesthetics and/or analgesics must also be given to prevent the condition known as "anesthesia awareness".
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What are the listed side effects for succinylcholine?
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- Apnea
- Malignant hyperthermia - Dysrhythmias - Bradycardia - Tachycardia - Hypertension - Hypotension - Cardiac arrest - Increased intraocular pressure - Fasciculations - Exacerbation of hyperkalemia in trauma patients |
Fasciculations are muscle twitches: small, local, involuntary muscle contractions and relaxations visible under the skin.
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What are the listed interactions for succinylcholine?
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- Effects potentiated by oxytocin, beta-blockers, and organophosphates
- Diazepam may reduce duration of action |
Organophosphates include many pesticides and nerve agents.
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What is the dosage and route of succinylcholine?
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Adult:
- 1 - 1.5mg/kg rapid IV, repeat once if needed Pedi: - 1 - 2mg/kg rapid IV/IO, repeat once if needed |
Succinylcholine has occasionally been used as a paralyzing agent for executions and as a means of murder and assassination.
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What are the pharmacokinetics of succinylcholine?
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Onset: 1 minute
Peak effect: 1 - 3 minutes Duration: 5 minutes |
Non-depolarizing blockers (e.g vecuronium, rocuronium) have a much longer duration but can be reversed.
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