• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/10

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

10 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
What is the best-known trade name for dopamine?
Inotropin
Dopamine was first synthesized in 1910 by George Barger and James Ewens at Wellcome Laboratories in London, England. It was named dopamine as its precursor in synthesis is levodopamine (L-DOPA).
What is the functional class of dopamine?
Sympathomimetic
Dopamine is a precursor to norepinephrine and then epinephrine
What is the mechanism of action of dopamine?
A naturally occurring neurotransmitter and catecholamine which acts on alpha and beta adrenergic receptors (dose-dependent), and dopaminergic receptors. In therapeutic dosages, dopamine maintains blood flow in the renal and mesenteric vascular beds. It is a positive inotrope, therefore it increases cardiac output and systolic BP.
Dopmaine can produce significant CNS effects but does not cross the blood-brain barrier.
What are the listed indications for dopamine?
- Cardiogenic shock
- Hemodynamically significant hypotension (systolic BP of 70-100mmHg not resulting from hypovolemia),
- Symptomatic bradycardia
Dopamine is also used to treat nonobstructive oliguria (low urine output).
What are the listed contraindications for dopamine?
- Pheochromocytoma
- Tachydysrhythmias
- Ventricular fibrillation
And, of course, known hypersensitivity.
What are the listed precautions for dopamine?
In doses 20mcg/kg/min or greater, its alpha effects dominate and it causes severe vasoconstriction. Monitor BP q 3 - 5 minutes. Can be deactivated by sodium bicarbonate
Some sources include a history of occlusive vascular disease (e.g, atherosclerosis, Raynaud's disease, Buerger's disease, diabetic endarteritis) and pregnancy (US FDA category C)
What are the listed side effects for dopamine?
- Dysrhythmias
- Palpitations
- Tachycardia
- Bradycardia
- Headaches,
- Anxiety
- N/V
- Tissue sloughing may result from dopamine extravasation
- Dyspnea
- HTN
Some sources include widened QRS complexes and azotaemia (abnormally high blood nitrogen levels).
What is the dosage and route of dopamine?
2-20mcg/kg/min IV infusion. Titrate to effect (BP)

Dopamine Dosage Range Effects:

Dose Range Result
2-5mcg/kg/min Dopaminergic Effects
5-10mcg/kg/min Beta Effects
10-20mcg/kg/min Alpha Effects
The "renal", "cardiac" and "pressor" doses.
What is the preparation for dopamine?
Place 800mg in 500mL D5W or NS = 1600mcg/mL
or
Place 400mg in 250mL D5W or NS = 1600mcg/mL
Dopamine is usually supplied in a 5mL (400mg) or 10mL (800mg) vial.
How should dopamine be used to treat hypovolemic shock?
Should not be used as the sole agent in the management of hypovolemic shock as fluid volume replacement is the primary treatment
"Tank before you crank".