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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
What is the best-known trade name for dopamine?
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Inotropin
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Dopamine was first synthesized in 1910 by George Barger and James Ewens at Wellcome Laboratories in London, England. It was named dopamine as its precursor in synthesis is levodopamine (L-DOPA).
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What is the functional class of dopamine?
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Sympathomimetic
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Dopamine is a precursor to norepinephrine and then epinephrine
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What is the mechanism of action of dopamine?
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A naturally occurring neurotransmitter and catecholamine which acts on alpha and beta adrenergic receptors (dose-dependent), and dopaminergic receptors. In therapeutic dosages, dopamine maintains blood flow in the renal and mesenteric vascular beds. It is a positive inotrope, therefore it increases cardiac output and systolic BP.
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Dopmaine can produce significant CNS effects but does not cross the blood-brain barrier.
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What are the listed indications for dopamine?
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- Cardiogenic shock
- Hemodynamically significant hypotension (systolic BP of 70-100mmHg not resulting from hypovolemia), - Symptomatic bradycardia |
Dopamine is also used to treat nonobstructive oliguria (low urine output).
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What are the listed contraindications for dopamine?
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- Pheochromocytoma
- Tachydysrhythmias - Ventricular fibrillation |
And, of course, known hypersensitivity.
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What are the listed precautions for dopamine?
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In doses 20mcg/kg/min or greater, its alpha effects dominate and it causes severe vasoconstriction. Monitor BP q 3 - 5 minutes. Can be deactivated by sodium bicarbonate
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Some sources include a history of occlusive vascular disease (e.g, atherosclerosis, Raynaud's disease, Buerger's disease, diabetic endarteritis) and pregnancy (US FDA category C)
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What are the listed side effects for dopamine?
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- Dysrhythmias
- Palpitations - Tachycardia - Bradycardia - Headaches, - Anxiety - N/V - Tissue sloughing may result from dopamine extravasation - Dyspnea - HTN |
Some sources include widened QRS complexes and azotaemia (abnormally high blood nitrogen levels).
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What is the dosage and route of dopamine?
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2-20mcg/kg/min IV infusion. Titrate to effect (BP)
Dopamine Dosage Range Effects: Dose Range Result 2-5mcg/kg/min Dopaminergic Effects 5-10mcg/kg/min Beta Effects 10-20mcg/kg/min Alpha Effects |
The "renal", "cardiac" and "pressor" doses.
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What is the preparation for dopamine?
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Place 800mg in 500mL D5W or NS = 1600mcg/mL
or Place 400mg in 250mL D5W or NS = 1600mcg/mL |
Dopamine is usually supplied in a 5mL (400mg) or 10mL (800mg) vial.
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How should dopamine be used to treat hypovolemic shock?
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Should not be used as the sole agent in the management of hypovolemic shock as fluid volume replacement is the primary treatment
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"Tank before you crank".
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