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9 Cards in this Set

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What is the best-known trade name for methylprednisolone?
Solu-Medrol
Another brand name is Medrol.
What is the functional class of methylprednisolone?
Corticosteroid
More specifically, methylprednisolone is a glucocorticoid.
What is the mechanism of action of methylprednisolone?
Intermediate-acting, synthetic adrenal corticosteroid. Decreases inflammation by reversing increased capillary permeability. This suppresses the migration of leukocytes and fibroblasts to the site of injury. Methylprednisolone also stabilizes lysosomes.
Glucocorticoids also inhibit the release of prostaglandins, leukotrienes and cyclooxygenase.
What are the listed indications for methylprednisolone?
Severe asthma, anaphylaxis or COPD.
In the non-emergency setting, methylprednisolone is also used for the the treatment of autoimmune diseases such systemic lupus erythematosus and as a treatment for multiple sclerosis.
What are the listed contraindications for methylprednisolone?
None in the management of anaphylaxis
When not treating life-threatening conditions, methylprednisolone is contraindicated for patients with a rectent history of certain infections such as varicella and rubeola (measles).
What are the listed precautions for methylprednisolone?
Patients with peptic ulcer disease, CHF, and TB.
Many sources add active infections, existing immunosuppression and many chronic disorders as precautions.
What are the listed side effects for methylprednisolone?
- Hypertension
- CHF
- Delayed wound healing
- Hyperglycemia
- Hypokalemia
- Headache
- Peptic ulcer
- Circulatory collapse
- N/V
- CNS depression
The most significant side-effects of methylprednisolone occur with chronic usage as it stops the natural production of cortisol, allowing for an Addisonian crisis if the methylprednisolone is suddenly stopped.
What are the listed interactions for methylprednisolone?
Use caution in patients on salicylates, phenytoin, rifampin, theophylline, furosemide, and thiazide diuretics.
Caution should also be exercised with patients who have recently received a vaccination.
What is the dosage and route of methylprednisolone?
Adult:
- 125-250mg IVP/IM

Pediatric:
- 1mg/kg IVP
NH dosing is 62.5mg for adults and 1mg/kg (max of 62.5mg) for pediatrics.