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9 Cards in this Set

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What is the chemical name for aspirin?
Acetylsalicylic acid (ASA)
Aspirin, with a capital "A", remains a registered trademark of Bayer in Germany, Canada, Mexico, and in over 80 other countries.
What are the functional classes of aspirin?
- Salicylate
- Analgesic
- Antiplatelet
- Antipyretic
Salicylic acid is found in willow bark and is the source of the name, from the Latin "salix" meaning "willow".
What is the mechanism of action of aspirin?
- Aspirin blocks the production of cyclooxygenase (COX), the precurser to thromboxane A2 (which is the physiological inducer of platelet aggregation).
- As an anti-inflammatory agent it appears to be involved in the inhibition of prostaglandin synthesis. Its anti-inflammatory actions also contribute to its analgesic effects.
- Aspirin also acts to reduce fever by causing centrally-mediated peripheral vasodilation and sweating.
Asprin has other modes of action which are less well-understood, including affecting mitochondria and reducing inflammation by at least two other mechanisms.
What are the listed indications for aspirin?
Suspected AMI, chest pain, or ACS
In non-prehospital arenas, aspirin has been used as a prophylactic for DVT in air travellers, to treat Kawasaki disease in children and investigated as an anti-cancer drug.
What are the listed contraindications for aspirin?
Hypersensitivity
Hypersensitivity to ibuprofen or naproxen may indicate hypersensitivity to aspirin.
What are the listed precautions for aspirin?
Peptic ulcer disease, asthma
Some sources include hemophilia and other disorders likely to result in excessive bleeding (such as Dengue fever).
What are the listed side effects for aspirin?
Overdose may result in considerable toxicity with dizziness, N/V, abdominal pain, thrombocytopenia, easy bruising, and/or metabolic acidosis.
Use of aspirin in children and teenagers can increase the likelihood of them devloping Reye's syndrome.

Large doses of aspirin can cause tinnitus.
What are the listed interactions for aspirin?
- Incompatible with uricosuric agents
- Anticoagulants increase the risk of bleeding
Ibuprofen can negate the antiplatelet effect of aspirin used for cardioprotection and stroke prevention.
What is the dosage and route of aspirin?
160 - 325mg PO (chewable) tablets
"Baby aspirin" are typically 81mg