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19 Cards in this Set

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Toxoplasmosis
TORCH
-Transmitted my consumption of contaminated water, shellfish, fruit, unpasturized milk, uncooked meat and eggs; contact with cat feces
-Highest risk of maternal-fetal infection: 10-24 weeks. 80% will present with severe problems
-Testing:
Skin test- very accurate for chronic infection
Serologic: specific to parasite
Amnio: fetal testing
Neonatal: Capture IgM ELISA
-Disease: generalized sepsis, neurological, preterm birth/ low birth weight
-Requires transfer of care
Rubella
TORCH
aka German Measles
Transmission: usually childhood infection- permanent immunity. Transmitted by coughing/sneezing secretions; these symptoms last 7-10 days to produce symptoms. Immunization does not always produce permanent immunity.
Other s/s include: swollen glands, throat, eyes and joints.

In pregnancy: primary infection is devastating to fetus. 50% malformations, if exposed < 8 weeks.
30% malformations if exposed 9-12 weeks. Risk declines after 12 weeks.
Testing: Routine screen for every woman.
> 1:10 = immunity
>1:64 = active or reccent infection
<1:8 = non-immune (at risk for infection)

Fetus can be diagnosed with cordocentesis, amnio, CVS, US

Maternal re-infection rarely a risk to fetus

Vaccination contraindicated prenatally
Cytomegalovirus
TORCH
DNA herpes virus

Transmission: sexual, all body fluid

Risk: low maternal age, poor, many partners

Prevention: hand washing, protected sex

Symptoms: like mono. Fever, lymph nodes, joints, throat.

Risk to fetus: Primary infection in the 1st half of pregnancy. reactivation of virus rarely a risk to fetus.

Testing: Screening not recommended. Primary infection detected by antibody test, but most people are asymptomatic in primary infection

Fetal Diagnosis: US, amnio, cordo <20 weeks
10% infected present with s/s: low birth weight, enlarged spleen, liver, jaundice, low platelets

No treatment, nursing ok
Herpes Simplex Virus type 2
TORCH
Routine screening not indicated

22% adults in general population infected- mostly genital. Most have mild or unrecognized infections

Primary HSV2: Only 33% present with s/s
S/S: vague discomfort, fever, swollen groin lymph glands, itching and burning @ outbreak site.
Outbreak: blister - ulcer - crusting up - heals w/o scarring. Virus travels to sacral ganglia- permanent.

Recurrent infections: less severe, brought on by diminished immune response. Triggers: menstruation, stress, poor nutrition, infection, sunlight,

Care: thorough history, education about prevention, refer for Rx- acyclovir

Birth: If lesions or prodromal s/s present after 36 weeks, surgical delivery indicated

Treatment: Zinc 300mg
L-lyseine 2000mg (prevent)
L-lyseine 5000mg (outbreak)
avoid nuts, seeds, chocolate, caffeine
supplement echinacea, calcium lactate, eliminate stress and triggers
Varicella
Torch
Chickenpox

75% of population immune- routine screening not recommended

Transmission: lesion fluid, respiratory droplets. contagious for ~15 days

S/s: slight fever, headache, backache, rash, pruritis

Tx: oatmeal bath, calomine lotion, homeopathic Rhus-Tox

Fetal Risk: 1-2% @ 7-20 weeks. Pigmented skin, short limbs, short fingers/toes, eye and CNS abnormalities, preterm labor, stillbirth

PN Diagnosis: Maternal Ab titer, US @ 18-20 weeks

Biggest risk for neonatal infection when mom has primary infection just before or after birth- baby has not received immunity yet.

Neonatal infection is usually mild.

V2IG vaccine NOT recommended during pregnancy

Varivax (live virus) contraindicated before and during pregnancy
Hepatitis B Virus
HBV
-Routine HBsAg titer for all pregnant women
-Transmitted by contact with infected blood, birth, nursing with cracked nipples
-Incidence in pregnancy 0.1-0.2%
-Neonatal risk- usually asymptomatic, 80% chronically infected, 10% develop jaundice
-HBV vaccine is routine for neonates. Recommended for known maternal infection.
Human Papilloma Virus
HPV (Genital Warts)

5-15% women infected, 90% of those are types 6 & 11.

Usually unrecognized, asymptomatic, clears up spontaneously

S/s: overgrowth of roughly textured tissue. cervical lesions

Types 6 & 11 can cause eye, nasal, oral, throat warts
Types 16 & 18 can cause genital lesions and cancer

Overgrowth around vulva may lead to excessive tearing during birth

Screening: pap smear. If +, colposcopy, biopsy

HPV vaccine contraindicated

Neonatal risk: usually not a problem. Xmission of types 6&11 may cause laryngeal warts, blocking airway. incidence low.
Chlamydia
Most common STI
2-12% of women in U.S. (20% in high risk pop.)
40%- gonorrhea coexisting
85%- asymptomatic

-S/s: prurlent yellowish dischargefrom cervix, inflammations

Risk to mom: PID (fever, abdominal pain, urethral infection.

Risk to baby: PROM, preterm labor, stillbirth, infection, death. S/s present 5-12 days after birth. Risk of conjunctivitis, blindness

Testing: culture via speculum exam, urine culture

Treatment: Mother and partner- refer for antibiotics
Neonate: eye prophylaxis (with apparent maternal infection at birth- IV antibiotics)
Gonorrhea
2nd most common STI
40% Chlamydia coeixisting
80% Asymptomatic

-Pregnant women prone to disseminated infection
S/s: Fever, joint pain, skin lesions, flu-like symptoms, genital inflammation

-R/O when presenting with pelvic pain in 1st trimester

-Reinfection common when immune response is poor

-Testing: GC culture

-Risk to fetus: preterm labor, prolonged ROM, chorio, PP infection

-Treatment: Refer for antibiotic treatment

-Neonatal s/s: conjunctivitis, blindness, loss of eye

-NB treatment: Prophylactic eye ointment (if mother presents with apparent s/s at labor, NB should receive IV antibiotic therapy)
HIV
Human Immunodeficiency Virus

Testing: Routine HIV-Ab blood test in pregnancy (ELISA). If reactive, repeat testing with Western Blot.

Refer/ Transfer care required

Maternal-child transmission 25-30%

Treatment: antivirals
Syphilis
Routine RPR for all pregnant women

Transmitted by contact with bodily fluids; maternal-fetal xmission.

Primary Infection: chancres @ site of contact, Onset ~9-90 days after exposure, lasting 1-8 weeks

Secondary infection: Onset ~3-6 months after chancres, presents with body rash and various systemic symptoms

Latent infection: Untreated syphilis. Onset 10-30 years after primary infection, usually no symptoms.

Late Stage: Tertiary Syphilis. Manifests 3-25y after primary infection. Neurological damage.

Testing: routine RPR. If reactive, TP-PA test to confirm.

Must refer/transfer care

Neonatal risk: 70-100% with infected mom
Defects, stillbirth, preterm labor, hydrops, rash or lesions. Placenta will look enlarged, pale, greasy.

Treatment: IV Penicillin G long term
1st Trimester Bleeding
May be due to:
Breakthrough bleeding (normal)
Implantation (normal)
Cervical erosion, polyps, cervical injury or cancer
Ectopic/ molar pregnancy
Threatened miscarriage

Monitor FHT/ Refer for US
RH negative moms: indirect Coombs, RhoGam
2nd Trimester Bleeding
May be due to:
Vigorous sex
Changing cervix
Placental abruption

Monitor FHT/ Refer for US
RH negative moms: indirect Coombs, RhoGam
Monitor for shock- refer/transfer
3rd Trimester Bleeding
May be due to:
Cervical change- normal if term
Placenta abruption
Placenta previa

Monitor FHT/ Refer for US
RH negative moms: indirect Coombs, RhoGam
Monitor for shock- refer/transfer
Pregnancy Induced Hypertension
PIH
Usually presents after 20 weeks
Not accompanied by s/s preeclampsia/ toxemia

Diagnosed by 2 elevated BP readings at least 6 hours apart

>140 systolic/ >90 diastolic

Light exercise, rest, deep relaxation, hydrotherapy

Brewer diet, adequate sodium intake, garlic, adequate hydration

No stimulants- caffeine, nicotine, drugs, spicy foods

Have mother assess BP at home

Herbs: hops, skullcap, chamomile

Supplements: Calcium, Magnesium, Potassium
Polyhydramnios
Increased amniotic fluid

Associated with fetal urinary problems, IUGR, Gestational diabetes

Refer for US/ physician consult
Gestational Diabetes
Hyperglycemia, secondary to insufficient insulin action

Causes dysfunction of various organs

Develops in later half of pregnancy

Screen at 24-28 weeks: blood glucose, A1c
>140 mg/dL blood glucose, collected 2 hours after consuming 50 g of sugary food/drink
glucosuria, ketones

May be controlled by dietary/ lifestyle changes
Brewer diet/ eliminate grain carbs
Retest

Risk to fetus: macrosomia, polyhydramnios, hypoglycemia at birth, preterm labor, shoulder dystocia, fetal anomalies

Mom at higher risk for toxemia, kidney problems
Preeclampsia
Prevention: good diet

Develops after 20 weeks

Hypertension- high bp on 2 separate occasions

Proteinuria- 0.3g in 24 hrs -or- >+1 urine dipstick
(clean catch, no UTI)

Elevated serum creatinine >1.2mg/dL
Low platelets <100,000/microliter
Elevated liver enzymes ALT, AST, both

Persistent headache, epigastric pain
Eclampsia (seizures)
May be superimposed on chronic hypertension if occuring <20 weeks
HELLP Syndrome
Hemolysis
Elevated Liver enzymes
Low Platelets

increased bilirubin, low WBC also seen

Usually hypertensive, but not a requirement diagnostically

Contracted blood volume, high Hgb @ 28 weeks