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11 Cards in this Set
- Front
- Back
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PAH often causes pro-thrombosis state |
1.5 to 2.5
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meds used to tx PAH
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CCB-mostly used
prostacyclin analogues endothelin receptor antagonists PDE-V inhibitors |
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name the prostacyclin meds
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epoprostenol
trepostinil lloprost |
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how do prostacyclins work
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act as potent vasodilators and inhibit platelet aggreg.
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prostacyclin SE
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NVD, (dose limiting: if it happens, reduce the dose)
chronic use-anxiety avoid interruptions in use, sudden reductions in dose |
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what is flolan and dosing requirement
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epoprostanol
pump needs to be on ice packs for proper cooling |
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veletri
gen name dosing requirements |
epoprostenol
but thermostable |
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name the Endothelin receptor antag (ERAs)
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bosentan
ambrisentan |
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bosentan
brand? BBW SE |
Tracleer
BBW- hepatotoxic, Cat X, SE- HA, decreases Hgb, increases LFTs, anemia REMS drug- risk eval and mitigation strategies |
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ambrisentan
brand? BBW SE |
Letairis
BBW- Cat X SE- peripheral edema, HA, decreased Hgb REMS drug |
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what are the PDE-V inhibitors for PAH
gen and brands |
sildenafil (revatio)
tadalafil (Adcirca) |
