Naplex Review Chapter 29 Dyslipidemia

Front 1

Risk factors for chd

Back 1

men >45 yoa, women >55 yoa
smoking
bp> 140/90 or on bp med
HDL <40
Fam history of CHD

-1 factor if HDL > 60

Front 2

LDL Goals
high risk CHD 10 yr risk >20 %

moderately high risk >2 R.F.

Back 2

<100

<130 if moderate risk CHD

Front 3

meds used to target LDL

meds used to target HDL

Meds used to target TG

Back 3

LDL- Statins

HDL- fenofibrates and Niacin

TG- exercise 1st, if >500 use fish oil or fenofibrates

Front 4

Statins
MOA
Class CI
Class SE
Class notes

Back 4

inhibit the enzyme, HMG-COa reducatase and enzyme needed to make cholesterol

CI- Acute liver dx, need CPK checked
SE- Myalgias, myopathy, rhabadomyolysis, cognitive impairment, increased BG,

Preg Cat X

Front 5

atorvastatin
brand
equiva dosd

Back 5

Lipitor
10mg, given any time of day

do not need to use lower doses if crCl <30

Front 6

simvastatin
brand
dose equiv
when to give

Back 6

Zocor

vytorin- simva/ ezetimibe
20 mg equiv
take QHS

Front 7

Rosuvastatin
brand
equiv dose
when to take

Back 7

Crestor
5mg
take any time of day

Front 8

pravastatin
brand
dose equiv
when to take

Back 8

pravachol
40mg
tk any time

Front 9

lovastatin
brand
equiv dose

Back 9

mevacor
40mg

with meal
altoprev- ER form is taken at bedtime

Front 10

fluvastatin
brand
equiv dose
when to give

Back 10

lescol
80 mg at bedtime

Front 11

pitavastatin
brand
dose equi
when to give

Back 11

livalo
2mg
take any time of day

Front 12

ezetimibe
brand
MOA
decreases how much of what

Back 12

zetia
inhibits absorption of cholesterol from small intestine
decreased LDL 20%
increases HDL 3%
decreases TG 10%

Front 13

Bile acid sequestrants
MOA
actions
SE
Preg cat

Back 13

binds bile acids in intestines, removing biles acid from recirculation

dec LDL 10-30%
increases HDL 5%
no change or may increase TG
Welchol is Cat B
SE- Constipation, abdominal pain, cramping, bloating

Front 14

colesevelam
brand
how to take

Back 14

welchol-also approved for DM2
take with meal AND full glass of water

has less GI effects than other BAS

Front 15

Fibrates
MOA

Back 15

PPAR alpha activators (note TZDs are PPAR-gamma agonists)

enhance elim of VLDL= dec TG AND increased HDL

but TG are high to begin, decreasing TG will increase LDL

Front 16

which fenofibrate is only one with indication for us with statin

Back 16

Trilipix

Front 17

fenofibrates
brands and their strengths

Back 17

tricor-48 145

trilipix 45, 135

Front 18

gemfibrozil
brand

Back 18

lopid

do not use with statins, increases myopathy chance

Front 19

which BAS can cause tooth decay

Back 19

cholestryamine if sipped

Front 20

Niacins
MOA
Effects
SE

Back 20

decreases rate of VLDL synthesis and LDL
dec LDL 5-25%, increases HDL 15-35%, dec TG 20-50%

SE- flushing, itching, diarrhea, GI, hepatotoxicity -monitor LFTs

Front 21

whats in advicor and simcor

Back 21

advicor= lovastatin + niasapan ER

Simcor= simvastatin + niasapan ER

Front 22

separate Niacin from BAS for how long

Back 22

4-6 H

Front 23

niasapan counseling

Back 23

take with small snack at bedtime
other niacins take with food

pre-tx flushing with aspirin 325mg 30 mins before dose

Front 24

Fish oils
MOA
SE
Preg cat

Back 24

may be due to reduced hepatic synth. of TGs up to 45%

adjunct for TG>500
SE- eructation (burping) dyspepsia
Cat C

Front 25

Omega3-fatty acids
brand
could possibly do what to cholesterol

Back 25

Lovaza
could increase LDL by 44%

Front 26

icosapent ethyl
brand

Back 26

vascepa
no increase in LDL like lovaza

Front 27

LDL equation

Back 27

LDL= TC-HDL-TG/5

TG can not be >500

Front 28

lopid
how to take

Back 28

600mg BID before breakfast and dinner

Front 29

which meds should be taken 4 h prior to welchol

Back 29

phenytoin, levothyroxide, glyburide, and oral contraceptives

Front 30

whats in caduet

Back 30

atorvastatin + amlodiplne

Front 31

which meds can dec TG by 10%

Back 31

Fish Oil (FO)
Fenofibrates (FB)
Niacin( Vitamin B)
all have 2 letters= TG, 2 letters