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14 Cards in this Set
- Front
- Back
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what is primary pathway of drug degradtion
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hydrolysis
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rate of dissolution is described by what equation
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Noyes-Whitney
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enteric coated meds dissolve where?
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in basic environment of small intestine
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describe 1st order kinetics
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most drugs follow this
more drug given, higher drug conc |
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what is michaelis-mentin kinetics
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saturatable kinetics
start as 1st order but goes into zero once enzymes are saturated |
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describe zero order kinetics
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elimination rate is independent of drugs concentration
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examples of drugs that follow saturatable kinetics
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phenytoin, theophylline, and voriconazole
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a small dose increase does what to conc levels in saturatable kinetics
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may result in a large increase in drug conc.
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advantages of ODT
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if a pt is nauseous can tolerate this easier
anti-migraine meds come in odt cause nausea is usually common with these headaches |
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describe concerta OROS
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a cap that contains IR/ER caps
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most patches can not be cut...an exception is..
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Lidoderm patches
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clonidine patches are used how often
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weekly
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diclofenac patches used how often
oxytrol (oxybutynin) patch how often |
twice daily
twice WEEKLY |
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what are the meds that are the exception to the no flushing rule
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fentanyl and buprenophine
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