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177 Cards in this Set
- Front
- Back
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Ziagen
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Abacavir
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Epizcom
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Abac + lamidvudine
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Trizivir
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Abac + lamid + zido
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Truvada
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Emtracitabine + tenofavir
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Atripla
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Emtra + tenof + efavarenz
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Combivir
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Lamidvudine/ zido
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Viread
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Tenofavir
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Sustiva
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Efaverenz
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Viramune
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Neviripine
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Edurant
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Rilpiverine
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Complera
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Emtracitabine/ tenof/ rilpiverine
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Reyataz
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atazanavir
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Prezista
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Darunavir
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Crixivan
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Indinavir
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Norvir
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Ritonavir
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Kaletra
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Lopinavir/ ritonavir
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Aptivus
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Tipranavir
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Fuzeon
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Enfuvirtide
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Selzentry
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Maraviroc
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Isentress
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Raltegrivir
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Primary treatment for HEP B and C?
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interferons
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Interferon MOA
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naturally produced cytokines that produces immune response & prevents viral replication
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Intron A
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inf alf 2b
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pegintron
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peg inf alf 2b
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pegasys
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inf alf 2a
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infergen
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inf alfacon-1
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what is intron a used for
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b c and cancers
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what is pegasys used for
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b and c
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what is pegintron used for
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c
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rebetron
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peg alf 2b + riba
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BBW for interferons
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life threatening immune, ischemic, neuropsych
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major side effect of interferons; when does it occur; what do you do about it
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flu like 1-2 hours post dose
give tyleol and benadryl |
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Bone marrow side effects of interferons
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anemias, ttps, neuropenias
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CNS side effects interferons
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flu like, HA, depression, psychosis, anxiety
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Pulmonary side interferons
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pnumonoitis
dyspnea |
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endorcrine side effects interferons
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hyper/hypo thyroid
hyperglycemia inc triglycerides |
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muscle joint side effects interferons
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pain
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cv side effects interferons
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syncope, htn, dysrhythmia
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eye side effects interferons
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decreased vision, retinal hemorrhages, optic neiritis
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when you take interferon what lab results do you expect to sky rocket?
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liver enzymes
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when do you withhold interferon tx?
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ANC < 500
Plts <25k |
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How do you keep interferon?
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in the fridge
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Do you shake interferon?
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no roll
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where do you inject interferon
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abz
upper arm thigh ROTATE |
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do you inject out the air bubbles of interferon?
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yes
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what degree angle do you inject interferon?
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either
45 or 90 |
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rebetrol
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ribavirin
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ribasphere
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ribavirin
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copegus
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ribavirin
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virazole
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ribavirin
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ribapak
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ribavirin
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how does riba come?
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soln
caps nebs |
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do you use riba alone?
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no. use with interferon
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do you use riba in hbv
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no
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What does RIBA stand for?
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Renal <50
Interferons Birth defects (pregnancy x) Anemia (hemolytic) |
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What high risk population would you not want to use riba in?
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unstable cardiac
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hwo long are you at risk for teratogenic effects after riba is d/c'ed
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6 months
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Protease inhibitors in Hepatitis ____ with a ______ are taken with
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C; genotype 1 infection; peg-riba
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Victrealis
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bocepravir
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How many times daily do you take victrealis? what is the specific dosing window? and who should this medication be taken?
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tid;7-9hrs;with food
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Major side effects of victrealis?
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1. anemia
2. fatigue 3. taste distubance |
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Incivik
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telapravir
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How should incivik be taken?
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tid; with meal with 20 grams fat
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MAJOR side effect of incivik unique to incivik NOT unique to victrealis
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SJS
dont forget about the taste disturbances, anemia, and fatigue |
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Tyzeka
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telbivudine
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baraclude
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entecavir
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viread
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tenofavir
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hepsera
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adeofavir
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epivir hbv
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lamivudine
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HBV Nukes BBWs
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1. lactic acidosis, hepatomegaly w/ steatosis
2. reactivation of hep b once d/c'ed |
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Which 2 HBV nukes are bad for the kidneys?
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Hepsera + viread
THE -OVIR drugs adefOVIR & tenofOVIR |
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Which HBV nuke needs to be taken on empty?
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Baraclude excludes da food
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Side effect of telbivudine
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muscle pains and shizniz
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Corgard
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nadolol
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Thiamine
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B1
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B1 prevents
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werneke korsekoff
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How do you titrate BB for portal HTN
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HR 55-60
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Sandostatin
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octreotide
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Pitressin
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vasopressin
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Enulose
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lactulose
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Generlac
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lactulose
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ABX to treat hepactic encephalopathy
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metro(sexual)nidazole
rifaximin neomycin |
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How do you treat ascities?
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sodium restriction <2 g / day
40 F : 100 aldactone in that ratio |
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class BBWs with the aids nukes
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hepatic steatosis
lactic acidosis, esp zido, didan, stav, |
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zianagen genomics?
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hla 5701
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videx/ videx ec
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didanosine
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videx administration
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on empty
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which aids nukes can cause hep b reactivation with d/c?
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emtra
lamidvu viread |
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weird side effect with emtracitibien
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skin pigment
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epivir
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lamivudine
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aids nukes for preggers?
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lamid
zido |
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retrovir
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zidovudine
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bbw for retrovir
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BMS, heme toxicity
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major side effects with viread?
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bad for kidneys
bad for bones fanconi |
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Hecoria
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tac
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neoral
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cyclosporine
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gengraf
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cyclosporine
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name 2 CNIs
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prograf
cyclo |
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moa of a cNI
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inhibits t-cell activation
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bbws for hecoria
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infections
lymphoma |
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bbws for gengraf
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renal imp w/ high doses
lympompa and cancers infection htn need experienced doctor to adjust dose gengraf/neoral cant be used interchangeably with sandimmine |
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compare the F of gengraf and neoral to sandimmune
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increased F
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side effects of neoral
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heres how youre gonna rememebr it
the 4 h's and the renal HTN Hyperplasia of gums Hirstitism Hypertrigliceridemia renal failure |
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metabolic side effects of hecoria
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diabetes
hyperk hypomag hypophos |
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hecoria side effects that are not metabolic
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hair loss
tremor HA kidney tox |
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how should hecoria be taken?
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on empty to avoid variable absorption
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cellcept
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MMF
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myfortic
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MPA
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how does myfortic work
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inhibits t lymphocyte proliferation by altering purine synthesis
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how does azasan work
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inhibits t lymphocyte proliferation by altering purine synthesis
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how is myforic formulated?
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enteric coated to decrease diarrhea
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how should myfortic bt taken?
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on empty
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how should cellcept be taken
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on empty
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whats up with preggers and cellcept?
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can cause a spontaneous abortion or congenital malformations
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whats the preg cat for myfortic
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d
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side effects of cellcept
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mostly gi in nature
DIARRHEA not constipation vomit painz |
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must taper off prednisone if used for longer than....
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7-10 days
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When taking imuran monitor for a deficiency in
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TPMT
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BBWs for imuran
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cancers
infections |
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rapamune
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sirol.
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how to take mycophenolate?
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every 12 horurs EXACTLY
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missed dose rule for MPA
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4 hour rule
contrast this to the 6 hour rule with Dabigitran |
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is it ok to take antacids or multivits with MPA?
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nope separate
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what food product should be avoided with neoral
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grapefruit j
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whats the missed dose rule with neoral
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same as mpa, 4 hour rule
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what kind of cup should you put neoral in and what should you mix it with?
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not styrofoam or plastic and should dilute with apple j j
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what food product should be avoided with tac?
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grapefruit j
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which immunesupp cannot be put in a styrofoam or plastic cup?
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neoral
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whihc immunesupp can prolon the qtc
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prograf
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what spf should you use for immune supps
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30 or higher
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when should you take the immune supp in relation to getting the level drawn/
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after the level take the meds
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shat if you have an allergy to smxtmp and you need pcp ppx (immune chapter)
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atovaquone
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doc for cmv?
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valgan
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rapamune side effect that is underlined in rxprep
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delawyed wound healing
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which 2 transplants should sirolimus not be used?
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liver
lung |
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zortress
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everolimus
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afinitor
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everolimus
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bbw for zortress
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reduce the dose of cyclosporine if used together
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Atgam-equine
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antithymocyte globulin
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orthoclone
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muromab cd3
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how do the acute rejection antibodies work?
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bind to antigens on t lymphocytes and interefer with their fxn
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class side effects of non nuckes
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hepatic
sj to the s |
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what s contraindicated with sestiva?
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ergots
midazolam triazolam st johns to the jay jay |
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intelence
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etravirine
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sustiva administration
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on empty
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edurant administration
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on full
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what's important about the edurant/ complera containers
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gotz ta keep the pillz inside yo
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important contraindications with edurant
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ppis
pretty much any broad spectrum inducer |
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ribavirin affects what class of aids meds
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nukes
increases levels of all nnrts |
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talk about reyataz and acid sippression
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okay so h2ras and AA: take it 2 hours before or 12 hours after h2ra/ 1 hour after aa
ppi 12 hours before |
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when are ppis not reccomended with reyataz
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unboosted
tx experienced |
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class side effects of the pis
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think metabolic
diabeetus insulin resistance lypodystrophy cholesterol hepatitis iris |
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aptivus
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tipranivir
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whats the big side effect with tipranavir
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intracranial hemmorhage
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what's the highest risk non nuke for sjs
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viramune
nevirapine |
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which pi's prolong pr?
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ritonavir
atazan lopinavir |
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which pi prolongs qt?
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lopinavir
saqinavir |
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which pis are to be avoided in sulfa allergy
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darunavir
tipranavir fosampran |
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invirase
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saqunavir
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which pis cause stones
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fosampranavir
crixivan atazan |
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lexiva
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fosampranivir
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bbw with ritonavir
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life threatening DI
watch SEDATIVE HYPNOTICS, ANTI ARRY, ERGOTS |
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WHICH PI should be taken on empty
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crixivan
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which pis should be dispened in original container
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crixivan
ritonavir caps |
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tell me about ritonavir and refrigeration
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tabs dont need it
caps do; good at RT x 30 days like many other drugs |
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which pi's come as a soln
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kaletra
ritonavir these gotz alcohol |
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major risk with aptivus
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intracranial hemmorhage
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how does the fusion inhibitor work
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gp120 (should be step 1)
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what is the fusion inhibitor
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enfuvirtide
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fuzeon
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enfuvirtide
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how is fuzeon given
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sc daily
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major risks with selzentry
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sjs
liver(bbw) |
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selzentry
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maraviroc
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isentress
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raltegravir
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imp monitoring parameter w/ isentress
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cpk
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where does isentress work?
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rpevents viral dna from entering host nucleus
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imp side effect with isentress
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sjs
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