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13 Cards in this Set
- Front
- Back
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What are myeloprolifative disorders ?
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a group of related disorders that are related in origin
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From where do myeloprolifative disorders start ?
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They begin in the bone marrow from a stem cells
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What are the 5 types of MPDs?
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-CML
-PV -Thrombocythemia -Myelofibrosis with myeloid metaplasia -CNL |
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What series of cells is Chronic myelogenous leukemia associated with ?
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the granulocyte strain
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What series of cells is Polycythemia Vera associated with ?
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erythroid series
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What specific diseases is associated with myelofibrosis ?
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angiogenic myeloid metaplasia and formation of fibrous tissue in the bone marrow
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What blood series is Thrombocythemia associated with ?
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megakaryocytes and platelets
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What does CNL stand for and what blood strain is involved ?
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Chronic neutrophilic leukemia
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Are those MPDs closely or not related ?
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they are closely related
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how are the MPDs interrelated ?
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A patient might start with one MPD and then evolve to another MPD
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What disease do MPDs usually terminate at ?
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most probably AML and less likely ALL
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What are some general clinical Features of MPDs ?
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splenomegaly
mild to marked leukocytosis thrombocytosis erythrocytosis some degree of marrow fibrosis |
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What is marrow fibrosis sometime thought about ?
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it is secondary to increase megakaryocytes and platelets
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