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21 Cards in this Set
- Front
- Back
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Heberden's Nodes
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- inflamm of the DIPs
- common in 10 generalized OA |
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1o generalized osteoarthritis epi
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- more common in women
- more familial |
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osteoarthritis radiology findings
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- fssures preprindicular to joint space
- thickened SCB (eburnated, or ivory like) - cysts - osteophytes |
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osteoarthritis micro findings
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- cartilages looses its ability to stain for proteoglycans
- caps may penetrate SCB and enter TM - newly formed cartilage cells duplicate the TM - SCB has thickened trabeculae - bad superficial chondrocytes, lots of deep ones - hypertrophies synovium w/ folds - low grade mono's |
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brood capsules
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- in OA there are bad superficial chondrocytes, lots of deep ones
- these are the deep ones, aka clones |
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OA pathogenesis
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- alterations in proteoglycans, esp aggrecan
- make shorter molelcues w/ smaller side chains and they cant hold water as well - tendency to synthesize type 1 instead of type 2 - IL-1 and TNF-a make metalloproteinase which degrated cartilage - OA chondrocytes make NO, that may inhibit GAG synthesis |
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Bouchards nodes
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cystic swellings on PIPs
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1o generalized OA PE findings
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- radial deviation
- Heverdens nodes, and Bouchards nodes - 1st CMC joint involved - narrowed webspace - trapezo-scaphoid may be involved - 1st MTP and TMT joints - MCP's, ankles spared |
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RF's for OA
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- ACL tear
- obesity - pre-existing varus (or, less commonly, varus) |
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gel phenomenon
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- OA only has bried stiffness in the morning
- or after a period of inactivity - we dont know why this happens |
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causes of 2o OA
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- CPPD deposition
- acromegaly - wilsons - hyperPT - hemocrhomatosis - ocrhonosis |
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charcot arthropathy
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- severe degen arthitis in joints deprived of pain inntervation
- may be tabes dorsalis, syngomyelia, DM |
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how is localized OA different from generalized OA?
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- likes the legs
- usually from old injury or repetivie occupational trauma |
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chondromalacia patellae
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- OA of patellofemoral joint of adolescents
- pain under patella w/ flexion or extension, annoying grating sensation |
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uncovertebral joints of Luschka and OA
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- osteophytes here can impinge nerve roots
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posttraumatic arthritis
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- from an intraarticular that wasn't reduces
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OA of hip radiograph
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superolateral or medial narrowing
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inflammatory OA radiograph
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- erosions of SCB
- no periarticular osteopenia like rA |
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diffuse idopathic skeletal hyperostosis
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- looks like OA on rad
- in old men - spinal stiffness w/ oseophyte formation of right side of vertebral bodies - oseophytes at large joins and SCB changes of OA |
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newer medical OA tx
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- oral glucosamine
- intraarciular injection of hyaluronic acid - implantation of autogenous carilage cells |
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surgical OA tx
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- debridement, osteotomy
- end-of-road are replacements and arthrodesis |
