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13 Cards in this Set
- Front
- Back
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axial mesoderm
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forms the notocord
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paraxial mesoderm
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- UG system
- somites - ventromedial somites become scleretomes thate form the vertebrae - dorsolateral somites become the dermomyotomes |
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parietal lateral plate mesoderm
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- body wall
- skeletal limbs |
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visceral lateral plate mesoderm
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- becomes the gut
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what part of the spine corresponds with the limb buds
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- C5-T1
- L2-S2 |
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fibroblastic growth factor
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- initiates limb bud outgrowth
- TBX 5 for upper limb - TBX 4 for lower limb |
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Apical Ectodermal Ridge
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- thickening of ecotderm on limb bud
- makes mesoderm proliferate - critical for proximo-distal growth |
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Zone of Polarizing activity
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- controls cranio-caudal outgrowth of limbs
- duplication can yield mirror image duplication of digits |
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what is the MSK system like at 6 wks gestation?
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- condensation of mesenchyme in central axis becomes cartilage
- Distal dermomyotome forms skeletal muscle - ventral 1o rami accompany the muscle cells |
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what happens to the cartilage in the center of long bones in development?
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they hypertrophy, die, and are invaded by caps growing in from the periostieum
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how do long bones grow in width with development?
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periosteal osteoblasts in membranous bone formation
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how do synarthroses joints form?
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loose CT b/t adjacent bones becomes fibrous tissue (syndesmoses for craineal sutures) OR cartilage (synchondroses for IV disk)
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how do diarthroses joints form?
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- from at 6th week
- cleft in mesenchymal tissue next to cartilage ends - peripheral becomes capsule and ligs, inner becomes synoveal membrane - intrauterine movement key |
