Ms - Arthritis

Front 1

effusion: definition and causes

Back 1

increased joint fluid
-infection (>100K WBC)
-inflamation (translucent or opaque fl)
-crystals (gout)
-inc. blood flow near joint
-inc. joint friction

Front 2

radiographic findings in OA

Back 2

narrowing of joint space (focal)
subchondral sclerosis
osteophyte formation
subchondral cysts

Front 3

radiographic findings in RA

Back 3

subchondral osteopenia
uniform joint narrowing
bond resorbtion
marginal erosions

Front 4

pannus

Back 4

granulation tissue of RA
formed by fibroblasts
errodes bone

Front 5

clinical findings in RA

Back 5

morning stiffness
polyarthritis
sys. manifest (CV, resp, ren, GI, neuro)
skin- rheum nodules
ocular conjunctivitis/scleritis

Front 6

labs in RA

Back 6

rheumatoid factor
Anemia of Chronic dz
increased ESR
+ test for ANA

Front 7

symptoms in OA

Back 7

pain w increasing activity (asymetrical)
usually in large weight bearing joints and distal fingers

Front 8

articular cartilage findings in OA

Back 8

decreased GAGs
chondrocyte loss
fissures
increased H2O content

Front 9

gene associated with RA

Back 9

HLA-DRB-1

Front 10

treatment for RA

Back 10

NSAIDS- initially
corticostaroids and DMRADS later

new: drugs that block tumor necrosis factor

Front 11

organism in septic arthritis that resembles RA- accompanies 'fifth disease'

Back 11

parvovirus

Front 12

PE of a child yeilds:
fever, refusal to walk/move affect limb, irritability, loss of appetite

Back 12

dx- Septic arthritis

Front 13

WBC and PMNs in septic arthritis

Back 13

wbc>50K
PMNs>90%

Front 14

STD presenting w fever, chills, rashes and bullous eruptions, polyarthralgias, tenosynovitis

Back 14

gonococcal arthritis (neisseria gonorrhea)

Front 15

erythema migrans-> neuro/CV manifestations-> late stage polyarthritis

Back 15

lyme disease

Front 16

Potts disease

Back 16

extra pul TB infection of spine.

Front 17

urate crystals, involvement of first metatarsal phalyngeal joint

Back 17

think gout

Front 18

pyrophosphate crystals, knees affected

Back 18

think pseudogout

Front 19

pathology of urate crystals in joints

Back 19

chemotactic factors attract neutrophills; stimulate release of inflammatory mediators from neutrophills

swollen, erythematous joint; resembles cellulitis

Front 20

insidious onset of low back pain, low back pain improving w exercise. eye/CV disease. HLA-B27 positive. Bamboo spine on radiograph

Back 20

ankylosing spondylitis

spine- ossificaiton of annulus fibrosus and intervertebral ligaments

Front 21

heel pain, 'sausage digits' for toes, and a positive HLA-B27

usually a reaction to chlamydia, yersinia, salmonella or shigella

Back 21

reiter's syndrome

Front 22

skin lesions (plaques), RA-like involvement of DIP and PIP joints

Back 22

psoriatic arthritis

Front 23

arthritis in knees or ankles associated with bowel disease (Chron's, ulcerative colitis)

Back 23

enteropathic arthritis

Front 24

treatment of seronegative arthritis

Back 24

NSAIDS
anti-TNF-alpha drugs

chlamydia- treat w doxycycline

Front 25

types of arthritis affecting fingers

Back 25

RA, OA, psoriatic

Front 26

spine/SI joint involvement with 'sausage digits'. Spine-> kyphosis

Back 26

spondylitis

Front 27

XR: well defined, progressive erosions. progressive destruction
+
Renal stones

Back 27

gout

Front 28

synovial fluid (septic)

Back 28

translucent/opaque
usually >100k WBC

WBC diferential- >90%pmns

Front 29

inflamatory synovial fluid
Gross
WBC
white cell diff

Back 29

translucent or opaque
wbc 20k-50k or greater
PMNs 50-90%

Front 30

normal synovial fluid
Gross
WBC
white cell diff

Back 30

gross: transparent
wbc <2k
>50% pmns