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19 Cards in this Set

  • Front
  • Back
How is rheumatoid arthritis defined?
A diffuse, chronic, systemic inflammation of connective tissue.
Rheumatoid arthritis selectivity targets what tissue?
Synovial tissue
Rheumatoid arthritis may affect what other tissues?
- Muscle
- Bone
- Heart
- Lungs
- Blood vessels
Rheumatoid arthritis affects the joint unilaterally. True or False?
False. It effects joints bilaterally.
In 50-80% of patients, what joints are effected by Rheumatoid arthritis?
- wrists
- elbows
- ankles
- knees
- cervical spine
At what age is the onset of Rheumatoid arthritis most typical?
20-60 years of age, with a peak between 40-50.
What gender is 3x more likely to get Rheumatoid arthritis?
When someone has Rheumatoid arthritis, what is happening on a cellular level?
There is an inflammatory autoimmune reaction of the synovial tissue
What antibody does the synovial fluid and blood of up to 70% of Rheumatoid arthritis patients contain?
The antibody Rheumatoid Factor
What is "pannus" tissue?
Proliferating synovial tissue, where granulation tissue covers the normal surface of synovial tissue.
What pathologic conditions occur in joints with Rheumatoid arthritis?
- soft tissue swelling
- loss of joint space
- bone erosion
- osteoporosis
What clinical features are present in a patient with Rheumatoid arthritis?
- Fatigue, malaise, general muscle weakness, low grade fever.
- insidious onset of pain
- Morning stiffness
- enlarged joints
- tender joints
- painful on motion of joints
- warm and red joints
- In chronic cases, joints are indurated and stiff
In a blood panel, what would the doctor find?
The Anti-cyclic Citrullinated Peptide Antibody (ACCPA), which is 100% specific for Rheumatoid arthritis.
On an x-ray, what pathologic changes would the doctor see?
- soft tissue swelling
- marginal erosion
- uniform loss of joint space
- juxta-articular osteoporosis
In the hand, what joints are affected by Rheumatoid arthritis?
The MCP joints, which cause ulnar deviation.
In the wrist, what joints are affected by Rheumatoid arthritis?
The carpals
What other joints in the body are affected by Rheumatoid arthritis?
- knees
- feet
- cervical spine in 50-80% of chronic patients
- Odontoid erosion, with damage to the transverse ligament, causing atlanto-axial instability.
If a doctor had a blood lab test peformed what would be found?
- In 80% of patients, there would be a positive Rheumatoid Factor
- elevated erythrocyte sedimentation rate (ESR) in 90% of patients
- Anemia in 80% of patients
- +C Reactive Protein
What is the treatment for Rheumatoid arthritis?
- Acute Stage: rest and anti-inflammatories
- In the non-inflammation state: manipulation and exercise
- Improved diet