Morpho 2 Practical – Systemic Pathology

Front 1

4. Pathology of GI-tract

1. Chronic superficial gastritis

Back 1

Macro:
- Infrequent swelling mucosa

Micro:
- Lymphocytes in foveolar layer of mucosa
- Lymphoid aggregates with greminal centers within
glandular layer of mucosa are common in
infec. with H. pylori
- No inflammatory infiltrate in
submucosa/muscularis

Front 2

4. Pathology of GI-tract

2. Chronic gastric ulcer

Back 2

Macro:
- Round sharply defect with straight walls
- Margins are flat, not ulcerated/elevated
- Base is smooth & clean
- Surrounding mucosal folds radiate from the ulcer
in spotlike fashon

Micro:
- Chronic ulcer involves the mucosa, submucosa &
muscularis
- Active ulcers have 4 layers, which reveal steps
from infl. to repair:
1. Neutrophils & cellular debris (on luminal
surface)
2. Fibrinoid necrosis
3. Granulation tissue
4. Fibrous scar (in the basis of the ulcer, the
deepest layer)

Front 3

4. Pathology of GI-tract

3. Gastric adenocarcinoma

Back 3

Macro:
- In this case, a protruding ulcerated mass (polypoid tumor)

Micro:
- Atypical gl.´s infiltrate:
mucosa, submucosa, muscularis & subserosa
- The subserosal lymph node presents metastases

IHC
- The tumor cells are marked by Cytokeratin &
Cytokeratin 20, which is specifically for carcinomas
of the Gi-tract