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56 Cards in this Set
- Front
- Back
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scrip writing legal basis
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state regulated fda controlled md
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otc
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safe,self limited conditions,fda
reg. |
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legend drugs
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must be prescribed by physician
bottle has to be labeled |
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sched 1
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highest research drugs
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sched 2
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highest abuse opiates oxycontin
high dependence |
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sched 3
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vicodin some abuse,low dep oral or written prescription. up to 5 refills within 6 months
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sched 4
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oral written unlimited refills ex
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sched 5
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low abuse minimal
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filling out prescription
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hand written no cursive dea #
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sig
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is directions for patient
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subscription below inscrip
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number of pills
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inscription
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drug name and dose
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superscription rx
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for pharmacist
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various types of pharmaceutical preps
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natural source ex opium
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crude drug
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dried
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pure
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example morphine
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pharmaceutical prep
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the form in which it comes
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routes of administration
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oral,parenterally im iv subq
sublingual,rectal,inhaled, |
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pharmokinetics
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how drug affects the body
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absorption
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passive of drug from site of admin to circulation
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distribution
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how it gets to the organs and tissues from exterstitial
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factors that effect drug absorption and distribution
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organ blood flow,1)lipid solubility molecular size PBP
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lipid soluble
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drugs go through easier
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first pass effect
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drugs abs0rbed reaach liver in hepatic portal
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p450 enzyme
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is an enzyme needed to breakdown drugs in the liver detoxifies drugs
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bioavailability
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fraction of the drug that reaches systemic circulation
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half life
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time needed to eliminate half of
the drug |
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steady
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administration has to equal elimination
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loading dose
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given to rapidly establish a theurapuetic dose
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receptor
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proten on cell membrane that drug binds to
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agonist drugs
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receptors that have high affinity and efficacy
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antagonist drugs inhibitor
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has high receptor affinity but lack efficacy
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renal problems
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poor elimination neonates and elderly excretion
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liver
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lower rate of oxidative reactions in neonates and elderly disease will decrease rate of metabolism
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creatinine
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kidney clearance
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bacteriocidal
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will kill organism fast acting
ex pen |
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bacteriostatic
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inhibits growth doesnt kill
contraindication cant be immune comprimised ex. tetracycline |
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MIC
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lowest concentration that inhibits growth
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how microbes exhibit resistance
3 major mechanisms IAA |
1)inactivation enzymes,2)decreased accumulation by decreased efflux or decreased uptake,3) decrease affinity
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role of host factors that affects drug
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renal liver function,immune status,allegies
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pharkinetic factors that affect drug you chose
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half life,peak concentration,absorption,distribution
elimination |
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general indications for combination drugs
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tb give it for
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synergistic
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2 together are greater than 1
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inhibitors bacterial wall synthesis
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3 most common pens,cephs,blac inhibitors
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there effects
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effects cell wall integrity binds to pbp in cytoplasmic inner membrane
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betalactam ABx
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dont allow assembly maintenance and regulation of cytoplasm
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penicillan v
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pharyngitis strep
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penicillanase resistant
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dicloxacillin,nafcillin
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ampicillan
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endocarditits
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piperacillin
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pseudomonas
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1st generation cefelexin
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uncomplicated uti ,skin and soft tissue prophalaxis surgery
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2nd generation two
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cefuroxime axetil know
for otitis media from hinluenza |
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3rd generation ceftrixone
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single dose gonnerhea
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4th generation cefepime
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not against mrsa
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tp
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tic pipericillan
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dic naf
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penicillase
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