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46 Cards in this Set
- Front
- Back
central nervous system
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brain and spinal cord
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Peripheral nervous system
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1. Somatic motor
2.Autonomic -Parasympathetic -sympathetic |
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parasympathetic nervous system
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Rest and Digest
- slowing heart rate -increasing gastric secretions -emptying bladder and bowel -focusing the eye for near vision -contracting bronchial smooth muscle |
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sympathetic nervous system
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-regulation of cardiovascular system
---^ maintains blood flow to the brain, redistributes blood, and compensates for blood loss^--- -regulation of body temp ---^regulates blood flow to skin, promotes secretion of sweat, induces piloerection (erection of hair)^--- -fight or flight response ---^increase HR and BP, shunting blood away from skin and viscera, dilating the bronchi, dilating the pupils, mobilizing stored energy^--- |
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transmitters
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-transmit impulses
-stimulate release of epinephrine and norepinephrine -activate receptors |
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receptors
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when activated cause a specific effect on an organ
-Vasodialation -Relaxation |
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transmitters of the pns
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-Aceytlcholine
-Norepinephrine -epinephrine -dopamine |
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receptors of the pns
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-cholinergic
-adrenergic |
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cholergenic
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-mediated by aceylcholine (ACh)
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adrenergic
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-mediated by norepinephrine and epinephrine
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cholinergic receptors
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-Nicotinic n
-Nicotinic m -Muscarinic |
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Adrenergic receptors
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-Alpha 1 and Alpha 2
-Beta 1 and Beta 2 -Dopamine |
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Nicotinic n (neuronal)
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Class: Cholinergic Receptor
Function: -promotes ganglia transmission -promotes release of epinephrine |
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Nicotonic m (muscle)
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Class: Cholinergic Receptor
Function: Contraction of skeletal muscles |
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Muscarinic
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Class: cholinergic receptor
Function: Activates parasympathetic nervous system |
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alpha 1
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Class: Adrenergic Receptor
Function: -Vasoconstriction -Ejaculation -Contraction of bladder neck and prostate |
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alpha 2
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Class: Adrenergic Receptor
Function: -Located int eh presynaptic junction -minimal clincal significance |
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beta 2
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Class: Adrenergic receptor
Function: -Bronchial dilation -relaxation of uterine muscles -vasodilation -glycogenolysis |
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dopamine
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class: Adrenergic receptor
Function: -Dilates renal blood vessels |
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alpha agonists
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stimulate alpha receptors
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alpha blockers
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block alpha receptors
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beta agonist
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stimulate beta receptors
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beta blockers
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block beta receptors
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Drugs that MIMIC pns
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-parasympathomimetics
-cholinergic drugs -cholinergic agonists -muscarinic drugs |
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Drugs thatBLOCK pns
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-parasympatholytic drugs
-anticholinergics -cholinergic antagonists -antimuscarinics |
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Drugs that MIMIC sympathetic nervous system
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-sympathoimetic
-adrenergics -adrenergic agonists |
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effects of SNS
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-BP increase
-Pulse increse -pupils dialate -secretions decrease |
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effects of PNS
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-BP decrease
-pulse decrease -pupils constrict -secretions increase |
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muscarinic poisoning
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-Source: ingestion of mushrooms
-Overdose |
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treatment for muscarinic poisoning
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muscarinic blocking agents-atropine
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pilocarpine
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-Class: muscarinic agonists
-Prototype Drug? yes Effects: -constricts pupils and cillary muscle improving aqueous humor drainage (decrease ocular pressure) Nursing Considerations: -teach proper eye drop admin -begin med in PM -report any eye pain -avoid OTC drugs -report respitory problems Other uses: for xerostomatitis Contradictions: -Asthma -peptic ulcer disease(PUD) Side Effects: -CV symptoms: dizzy,flushing,diaphoresis,reflex tachycardia,risk of A fib -Bronchospasm -increased lacrimation -decrease vision |
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bethanacol
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Class: muscarinic agonist
Prototype drug? yes Uses: -acute urinary retention -GERD -Ileus -postoperative abdominal distention Administration: PO or SC CAUTION: do not give IM or IV or with mechanical GI obstruction or after GI surgery Nursing Considerations: -atropine on standby -assess bowel sounds and skin flushing -may catheretize in 30min if no response |
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muscarinic antagonists
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drugs that block the action of acetylcholine at muscarinic receptors
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atropine
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Actions:
-increases heart rate -decreases secretions -relaxes bronchial muscle -decreases bladder tone -decreases GI tone and motility -dilates the pupil -CNS excitation Uses: -Pre-anesthestic -Disorders of the eye -bradycardia -intestinal hypertoxicity and hypermotility -muscarinic agonist poisoning -asthma -biliary colic -peptic ulcer disease (PUD) Adverse effects: -dry mouth (xerostomia) -blurred vision -photophobia -increaes intraocular pressure -urinary retention -constipation -tachycardia -anhydrosis (lack of sweating) -asthma |
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antimuscarinic/Anticholinergics
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Uses:
-symptomatic bradycardia -eye exams -bladder spasms -urinary frequency or incontinence -rhinorrhea -mushroom poisoning |
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antimuscarinic/anticholinergic drugs
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Uses:
-Symptomatic bradycardia -eye exams -bladder spasms -urinary frequency or incontinence -rhinorrhea -mushroom poisoning *w/ anesthesia -decrease bronchia secretions -prevent bradycardia -prevent side effects of AChEt Side Effects: -dilation of pupils (photophobia) -absolute contraindication: Glaucoma(increased intraocular pressure) -slows GI tract motility:constipation -urinary retention -respiratory distress:thickened secretions -speeds heart rate -xerostomia |
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examples of antimuscarinic drugs
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-Scpolamine
-Ipatoprium bromide -dicyclomine --trihexyphenidyle (Artane) -Benztropine (cogentin) *last two in Parkinson's disease |
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antimuscarinic poisoning
cause? |
caused because epinepherine predominates
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sources of antimuscarinic poisoning
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-Atropa belladonna
-datura stramonium -antihistamines -phenothiazines -tricyclic antidepressants -atropine -scopolamine |
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symptoms of antimuscarinic poisoning
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direct result of excessive muscarinic blackade
-dry mouth -blurred vision -phtophobia -hypethermia -CNS effects(delerium) -flushing -respiratory depression causing death |
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treatment of antimuscarinic poisoning
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1. Minimize intestinal absorbtion
-syrup of ipecac -activated charcoal 2.Administer the antidote -Phystigmine (neostigmine) (AChel) -This will compete with the antimuscarnic agent for receptor binding, there byreversing excessive muscarinic blockade |
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cholinesterase inhibitors
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-drugs that prevent the degradation of acetylcholine by acetylcholinesterase
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effects of cholinesterase inhibitors
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-effects muscarinic and nicotinic receptors
-same as parasympathomimetic drugs ---excessive slaivation,sweating,urinary urgency,diarrhea |
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A patient is scheduled for a procedure that requires axon conduction blockade. Which medication will the nurse obtain?
A. Receptor agonist B. Receptor antagonist C. Local anesthetic D. Beta2 Blocker |
C- it is non selective and will numb wherever the nurse puts it.
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A patient receives medication that results in activation of the acetycholine receptors of the heart the nurse should assess the patient for which intended effect?
A. Decreased heart rate B. Dysrhythmia suppression C. Increased heart rate D. Improved contractility |
A. Decreased heart rate
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Parasympathetic Nervous System Drugs aid in what?
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- Digestion of food
- Excretion of waste -Control of vision - Conservation of energy |