Molecular Boards: Oncology

Front 1

1p/19q loss: what does it mean?

Back 1

better outcomes in oligodendrogliomas

Front 2

1. What are the anti-EGFR drugs for colon cancer?

2. Lung cancer?

Back 2

Monoclonal antibodies (for colorectal cancer)
§ Cetuximab
§ Panitumimab
Small molecule inhibitors (for lung cancer)
§ Erlotinib
§ Gefitinib

Front 3

Why check for KRAS mutations in colon cancer?

Back 3

Mutations in KRAS signal resistance to cetuximab. Mutations are seen in 20% of colon cancers

Front 4

Why test for EGFR mutations in lung cancer?

Back 4

Even though non-mutants and mutants alike respond to therapy- some specific genotypes are both sensitive and resistant to therapy.

Front 5

Why test for the V600E mutation in BRAF?

Back 5

It is the most common mutation in the BRAF gene, It can be helpful in the DX of papillary thyroid cancer,
Helpful for HNPCC DX vs sporadic forms

Front 6

1. Ewings sarcoma translocation and gene?
2. Alveolar rhabdomyosarcoma?
3. Synovial Sarc
4.
5.
6.
7.

Back 6

1. Ewings: t(11;22). (EWS1)
2. Alveolar rhabdomyosarcoma- t(2;13) (PAX3)
3. Synovial Sarc t(X;18), SSX1

Front 7

What are the oncogenic tyrosine kinases?
1.
2.
3.
4.

Back 7

tyrosine kinases
1. BCR-ABL
2. HER2
3. EGFR
4. KIT
5. PDGFRA

Front 8

What are the 2 variants of HNPCC related disease?

1.
2.

Back 8

HNPPC variants
1. Turcot syndrome- HNPCC+glioblastoma
2. Muir-Torre Syndrome- Colon + sebaceous adenomas

Front 9

MSI testing- what are the definitions of:

1. MSS?
2. MSI-L?
3.MSI-H?

Back 9

MSI
1. MSS- microsatillite stable-
2. MSI-L- instability at 1 locus
3.MSI-H- instability >1 locus

Front 10

Why test BRAF for mutations in suspected HNPCC cases?

Back 10

Mutations found in 40% of sporadic cases, not in HNPCC/Lynch.

Front 11

FAP
1. What percent of FAP cases are sporadic?
2. What are the 2 syndromes associated with FAP?
3. How do you test?

Back 11

1.25%
2. Turcot syndrome (medulloblastoma), Gardner's syndrome (FAP + osteomas, epidermoid cyst, desmoid tumors)
3. Direct sequencing of APC