Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
IBS |
One allele in the founder generation has come down two sides of the pedigree - seen as a recessive condition in individuals |
|
|
|
IBD |
Two random people have the same number of repeats in their micro-satellites - same mutation in their gene by chance |
|
|
|
Chance of suffering from diseases due to recessive condition |
25% |
|
|
|
Linkage is useful when |
Have a mendelian disease Have a large family Penetrance is high Phenocopies are low |
|
|
|
Genetic drift is dependant on |
Age in evolutionary history Selection pressure Migration patterns Sample size |
|
|
|
Stromatolites |
Lime secreting Cyanobacteria present 3.4 byo |
|
|
|
Haematatie |
Fossilised exoskeleton present 3.7 byo |
|
|
|
Carbon 12 increase due to respiration of plants |
3.9 byo |
|
|
|
Oparin Haldane Hypothesis |
Prebiotic soup, aq environment |
|
|
|
Lipid world |
Forms naturally and self aggregates, hydrophobic core is ideal in aq environment |
|
|
|
RNA world hypothesis |
Montmorollinatie Clay has holes ideal for RNA subunits allowing nucleotides to make chains |
|
|
|
Geothermal vents |
Unique mineral in warm water react faster and concentrate in aq environment |
|
|
|
Panspermia |
Radio - propelled by UV, then burned Lito - life on rocks from other planets, no evidence Accident - rubbish left by aliens, no evidence Direct - microorganisms deliberately sent by aliens, no evidence Pseudo - molecules formed from start at Big Bang, no uniform distribution |
|
|
|
Deoxyribose |
H |
|
|
|
Tm |
4GC + 2AT |
|
|
|
Replication in bacteria |
Single 245bp site 4 x 9bp motif dnaA 3 x 13bp gaps in OriC dnaB enters DNA strand - proteins alter the conformational shape |
|
|
|
Virus SV40 |
T antigen binds to a specific 64bp DNA region Site II to open DNA |
|
|
|
Yeast |
ORC binds specific 11bp DNA sequence known as Domain A and Domain B and unwind Domain B2 |
|
|
|
Origin of replication recruits proteins then |
Cdc6 Cdt1 Mcm2-7 And activated by kinase Cdk2 Dbf4 |
|
|
|
Topoisomerase |
Untwist DNA in eukaryotes |
|
|
|
Type II topoisomerase |
Cuts circular DNA |
|
|
|
Telomerase |
Has RNA template that binds ssDNA and extends it Then acts as reverse transcriptase and fills in the end |
|
