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26 Cards in this Set
- Front
- Back
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most abundant and most important inhibitory NT
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GABA
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GABA- charge?
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neutral amino acid
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Glycine (2)- structure
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gamma-aminoacetic acid.
The most simple aminoacid. |
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GABA # of subunits (for each type- voltage and ligand)
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voltage- 4 subunits
ligand- 5 subunits |
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taurine chem name
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2-aminoethanesulfonic acid.
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how do GABA agonists work to depress CNS? (2)
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Facilitate hyperpolarization of the cell
BY gating chloride ions in the interior of the nerve cell prevents firing of presynaptic NTs |
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% of neurons that have GABA receptors in CNS
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70
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3 excitatory NTs (know structures (3)
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glutamate
aspartate N methyl asparate |
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how to excitatory NTs work?
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Depolarizes - let chloride ion channel go out of the cell
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GABAa receptor type
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ligand gated ion channel
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ligand gated ion channel aka...
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ionotropic?
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4 agonists of GABAa
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Isoguvacine
tetrahydroisooxazole pyridinol muscimol ibofenic acid |
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2 antagonists of GABAa
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bicuculine
picrotoxin (mixture of 2 compounds) |
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importance of GABAa antagonists
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mimic epilepsy in lab setting
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GABA-B RECEPTOR
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voltage gated ion channel????
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muscimol
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alkaloid- with psychoactive properties
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picrotoxin- usage
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barbiturate poisoning
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Isoguvacin- (4)
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4 carbons, COOH and nitrogen
like GABA but in locked position- so prob this is conformation GABA needs to bind locking conformations- by adding double bonds |
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GABAb agonist
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baclofen
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baclofen SAR
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looks like GABA except lockd with double bond and has phenyl ring/Cl
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GabaB type of receptor
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GPCR
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3 antagonists for GABAb
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phaclofen- baclofen with phosphoric acid
saclofen- baclofen with sulfuric acid 2-hydroxy saclofen SELECTIVE |
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GABA-C RECEPTOR agonist
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cis-Amino-2-butenoic acid
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GABA-C receptor antagonist
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(tetrahydropyridinyl)methylphosphonic acid
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GABA-c receptor type
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ligand gated ion channel
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exam-- what to know for GABA agonists/antagoinsts
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know which is agonist for all 3 receptors types (GABA)
muscimol** isoguvacin** bicuculine** picrotoxin** baclofen** GABAc agonist** |
