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55 Cards in this Set

  • Front
  • Back

Perprosthetic lucency

Prosthetic joint infection

Late onset joint infection cause

>24 month post surgery


Due to hematogenous spread

P-ANCA

Perinuclear pattern - microscopic polyangitis

Organs involved in Microscopic polyangitis

Lung and kidney

Non granulomatous Necrotizing pauci-immune small vessel vasculitis

Microscopic polyangitis

Kidney biopsy in microscopic polyangitis

Pauci-immune Necrotizing crecentric GN

Precautions with pegloticase

Stop other urate lowering therapy as antibodies develop to pegloticase which would manifest as riding urate level.


This would get masked if other urate lowering therapy are used concominantly

Pegloticase mechanism of action

Porcine derived uricase - lowers irate within hours of administration

Prophylaxis with pegloticase

Stop urate lowering medications



Start anti-inflammatory to prevent attacks - NSAID, prednisone or colchicine

Probenecid contraindication

GFR <60 i.e. any kidney disease



Or



Kidney stone

Urate target per ACR

If no tophi : uric acid <6


If tophi : uric acid <5

Reactive arthritis trigger

Chlamydia trachomatis

Ankylosing spondylitis criteria

Low back pain >3 months


In person <45 yr of age


Limited spinal movement


Elevated inflammatory marker


Bilateral sacroilitis on imaging

GAVE syndrome

Gastric Antral vascular ectasia - linear ectatic vessels that arise from the pylorus

GI bleeding in diffuse Scleroderma

GAVE syndrome - proliferation of blood vessels in pylorus

Causes of GAVE/watermelon stomach

autoimmune condition


Or


Portal hypertension due to cirrhosis

Treatment of GAVE

Argon plasma coagulation or laser coagulation

Ulcers in hiatal Hernia are called?

Cameron ulcer - caused by mechanical trauma as the hernia slides up and down



Present on the crest of gastric fold

Dieulafoy ulcer are

Submucosal Arterioles that bleed intermittently.


Present on lesser curvature of proximal stomach

Portal hypertensive gastropathy endoscopy appearance

Mosaic appearance affecting body and fundus

Treatment of Steroid resistant acute gout

Anakinra



Colchicine, steroids or nsaid won't be effective at this point

Indication for surgery in OA

Pain at rest


Pain that awakens at night

Anti jo 1 antibody

Antisynthetase syndrome

Mechanic's hand

Hyperkeratotic skin along ulnar aspect of thumb and radial aspect of fingers (index and middle commonly)

Risk factor for


1. RA


2. Gout


1. Smoking


2. High fructose corn syrup

ESR, CRP abd complements in lupus

ESR is elevated


CRP is generally normal or slightly elevated


Hypocomplementia

Acute lupus pneumonitis

Diffuse pulmonary infiltrate in poorly controlled lupus patient


Lymphocytic prodominence on bronchoalveolar lavage

Diarrhea in systemic sclerosis etiology

1. Decreased mobility leading to SIBO


Or


2. Chronic pancreatic inefficiency leading to SIBO



diagnostic test for SIBO

Glucose hydrogen breath testing



Or



Jejunal aspirate cultures

Monoarticular minimally painful disease (*knee*)

Lyme disease

Antibody Associated with retroperitoneal fibrosis

IgG4

Anticentromere antibody

90% specific for Scleroderma


Limited cutaneous systemic sclerosis


Increased risk of pulmonary arterial hypertension

Anti U1 ribonucleoprotein

Mixed connective tissue disease

Systems involved in polyarteritis nodosa

Skin - necrotic ulcers and purpura kidney - hypertension d/t renal artery vasculitis and infarction


Nerve - mononueritis multiplex


Orchitis - unilateral due to testicular artery involvement


Mysentric vasculitis


Polyarteritis nodosa triggers

Hepatitis B


HIV


Hairy cell leukemia

Median age of Giant cell arteritis presentation

70 years

Giant cell arteritis prednisone dose

If vision loss start with 60mg per day for 1 month.


Decrease by 10% weekly if improving

Muscle involvement in inclusion body myositis


Muscle involvement in inclusion body myositis


Muscle involvement in inclusion body myositis

Proximal and distal muscles

Eye manifestation with Rheumatoid arthritis

Scleritis - Painful eye movement, redness, photophobia

Large vessel vasculitis types

Young age - takayasu vasculitis


Old age - giant cell arteritis

PMR relapse treatment

Increase back to last pre relapse dose of prednisone

Treatment of primary angitis of central nervous system

Cyclophosphamide

IBS related refractory arthritis treatment

TNF alpha inhibitor -


Adalimumab


pegol


Certolizumab pegolGolimumabInfliximab


Golimumab


Infliximab


Differentials for chronic monoarticular synovitis

Mycobacterium


Lyme disease


Fungal disease


Sarcoidosis

Markers tested in lupus flare

ESR (elevated)


C3/C4 (low)


Anti dsDNA (elevated)



CRP (elevated if infection)


Anti Smith (used only for diagnosis)


Antibodies for Inclusion body myositis

Anti cytosolic 5' nucleotidase 1A

Antibodies for immune mediated necrotising myositis

HMG coA reductase antibodies.

Biopsy in immune mediated necrotizing myositis

Necrotic muscle with minimal inflammatory cells which DO NOT invade the muscle fibers

Differentials for parotid enlargement

Sjogren syndrome


Sarcoidosis


HIV associated diffuse lymphocytic infiltrate syndrome


IgG4 related disease

Treatment of ILD secondary to scleroderma

Mycophenolate mofetil

Lofgren syndrome

Bihilar adenopathy


Arthritis (generally ankle joint)


Erythema nodosum

Organ involved IgA vasculitis

Skin - purpura


Bowel - abdominal pain, intussusecption


Kidney rarely


Pulmonary hemorrhage

Risk factor for allopurinol sensitivity

Han dynasty Chinese population (HLA B*5801)


Thai or Korean decent


CKD


Diuretic use

First line Treatment of ankylosing spondylitis

NSAID



if fails, try TNF-a inhibitors

Trachealization of esophagus is seen in

Eosinophilic esophagitis