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6 Cards in this Set
- Front
- Back
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2 divisions of the cell cycle
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interphase:
G1-presynth S-DNA synth G2-post DNA dup Mitosis: prophase-condensed chromatin no nuc envelope metaphase-chromes in cntr of cell anaphase-chromes move apart telophase-sepatation/cytokinesis |
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Regulation of cell cycle
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-GF's stimulate cells to divide
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What drives cellular changes as it goes through mitosis
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-in G2 accumulation of MPF
induces: -beginning of mitosis -condensation of chromos -rupture of nuc env for separation of chromos *phosphorylation of lamins=breakdown of nuc env |
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Cell crawling
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needs actin to move/integrin to attach
4 stages: -extension=lamellipod moves b/c of actin polymerization -adhesion=lamelipod attaches to integrin focal pt.s the back myosin contracts & pulls body -translocation -deadhesion |
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Crawling cont.
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-actin polymerization @ + end protrudes lamellipodium
-actin & myosin bundles contract & pull body forward * actin->integrin->focal adhesions->attachment to substratum of ECM |
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Regulation of cell activity of integrins
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-activity is regulated by cells
-activated by intracellular sig paths by binding ligands -migrating cells follow these sigs like tracks |
