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6 Cards in this Set

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  • Back
2 divisions of the cell cycle
interphase:
G1-presynth
S-DNA synth
G2-post DNA dup
Mitosis:
prophase-condensed chromatin no nuc envelope
metaphase-chromes in cntr of cell
anaphase-chromes move apart
telophase-sepatation/cytokinesis
Regulation of cell cycle
-GF's stimulate cells to divide
What drives cellular changes as it goes through mitosis
-in G2 accumulation of MPF
induces:
-beginning of mitosis
-condensation of chromos
-rupture of nuc env for separation of chromos
*phosphorylation of lamins=breakdown of nuc env
Cell crawling
needs actin to move/integrin to attach
4 stages:
-extension=lamellipod moves b/c of actin polymerization
-adhesion=lamelipod attaches to integrin focal pt.s the back myosin contracts & pulls body
-translocation
-deadhesion
Crawling cont.
-actin polymerization @ + end protrudes lamellipodium
-actin & myosin bundles contract & pull body forward
* actin->integrin->focal adhesions->attachment to substratum of ECM
Regulation of cell activity of integrins
-activity is regulated by cells
-activated by intracellular sig paths by binding ligands
-migrating cells follow these sigs like tracks