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672 Cards in this Set

  • Front
  • Back
Estrogen - gall bladder
hypercholesterol via increased HMG-CoA reductase
Ataxia telangectasia
Inefficient DNA repair with immunodeficiency [URIs] and cerebellar atrophy
Increased AchE in aminocentesis
Failed neural tube closure [in addition to AFP]
N-acetylglutamate
Activator of Carbamoyl phosphate synthase I - first step of the urea cycle
N-acetylcystine
Acetaminophen overdose
Folinic acid
"Leucovorin, methotrexate rescue"
Odansetron
"5-HT3 antagonist, tx NV during chemo"
Filgrastim
G-CSF
Dexrazoxane
"Iron chelation, for doxorubicin"
Amifostine
Free radical scavenger for platinum chemo
Pre-eclampsia
"Hypertension, proteinuria, edema during pregnancy"
Loop of henle Potassium
Na/k/2Cl cotransporter
Carbon monoxide
Strong competitive binding to heme [220x]
Actinomyces israelii
"Cause cervicofacial actinomycosis, yellowish pus"
Ecthyma gangrenosum
"Psudomonals bacteremia, exotoxins causing skin lesions"
Delusional disorder
Situational paranoia
Dopamine on the heart
Low: increased renal blood flow. Mid: B1 agonist too. High: a1 agonist
"""-glitazone side effects"
Check LFTs [hepatotox]
EBV malignancies
"Nasopharyngeal carcinoma, Burkitt's lymphoma"
Tetanus toxin
"No assay, clinical exam"
Kawasaki's disease [4 items]
"Fever, bilateral conjunctivitis, lymphadenopathy, cutaneous [strawberry tongue, palm/sole edema/erythema, rash]"
Diphenhydramine side effects
"Antimuscarinic, anti alpha adrenergic, anti serotonergic"
Neuroleptic malignant syndrome
"Haloperidol induced, causes anti-dopaminergic sx: [hyperthermia, rigidity, autonomic instability, altered MS]"
Valproic Acid Pregnancy
Neural tube defects
Capitation payment
Pay per enrollee
Superior gluteal nerve location
Superiomedial quadrant of the butt
Gallstone forming meds
"Fibrates, cholestyramine"
Fabry disease
"x-linked, Angiokeratoma is a Fabric of vessels and Galaxy of skin spots"
Gaucher's
"Glucocerebroside, Gaucher's macrophages, HSM, pancytopenia"
Hurler/hunter's
"Hunter is pointing his gun to the X. Hurler who's like Hunter but because of corneal clouding he can't hunt well, Heparin and Dermatan sulfate"
Niemann Pick
"No man picks is nose with hi- Sphinger; HSM, Cherry-red"
Tay Sach's
"GM2 ganglioside - cherry red with no HSM, neuro"
Krabbe
"Galactocerebrosidase, neurodegeneration"
Metachromatic leukodystrophy
"arylsulfatase A, muscle wasting, dementia, ataxia"
Atelectasis ? Compliance
Decreased compliance
Familial gestational diabetes
Glucokinase [mild] deficiency in B cells
Pramipexole
Dopamine agonist
HIV pol
polymerase genes
HIV gag
p-genes
HIV env
gp-genes
Alkaptonuria
"Tyrosine to fumarate, black urine"
Opiate- no tolerance developed
Comstipation and miosis
B6 deficiency
Sensory ataxia and decreased pain sensation
Sensory ataxia and decreased pain sensation
B6 deficiency
"Anastrozole
letrozole, exemestane",Aromatase inhibitors [breast cancer]
NSAID nephropathy
Chronic interstitial nephritis
Oxalate crystals in tubule lumen
ethylene glycol poisoning
Chancre
primary syph
Gumma
tertiary syph
Condyloma lata
secondary syph
Breakdown of bruises
Heme oxygenase
Petichial rash on trunk and extremities + meningitis
Meningococcus
Aspiration pneumonia
"Oral contents, not gastric!"
Chediak Higashi syndrome
"Immunodeficiency, albinism, neurologic"
Swelling painful hands and feet in a newborn
Sickle cell
HIDA scan
gallbladder radionucleotide
Traveller's diarrhea
"ETEC, cholera like toxin"
Blood in stomach after severe trauma
Stress-related mucosal erosion
MNGC w/ internuclear inclusion
"Tzanck stain, Herpes"
Nitroglycerin effects
Decreased ventricular preload
Hep B damage
Mostly CD8 killing
Niacin effects on HTN and DM
"improve HTN, worsen DM"
Facial palsy and joint arthritis
Lyme
Lithium interactions
"HCTZ, ACEi, NSAIDs increase lithium load -> neurologic symptoms"
Lithium toxicity
hemodialysis
Unilateral fetal hydronephrosis
Obstruction at the ureteropelvic junction
WFS
Meningococcus
Cardiac effects of alcohol overdose
A Fib
Foot drop
Common peroneal nerve injury
Vertical diplopia
trochlear nerve
ventromedial hypothalamus
leptin sensitive, eating
Ovary supply
suspensory ligament
Emergency airway
Between the thyroid and the cricoid cartilages
Testes drainage
para aortic
Penis drainage
deep inguinal
Cutaneous drainage
superficial inguinal
haloperidol side effects
parkinsonian, tx: benztropine
Berkson's bias
hospitalized subjects
Hawthorn bias
being studied changes behavior
Pygmalion bias
researcher's belif in the efficacy of treatment
Lead time bias
screening study has apparent tx effect
VIPoma
secretory diarrhea, inhibited by somatostatin
Isoniazid activation
catalase peroxidase
isoniazid supplementation
B6
Pyranzimide
decreases cell pH, needs activation
Homocystinuria
tx with B6
Glycogen phosphorylase signalling
Ca via PKA/NE/Ca
Turner's syndrome
lymphadema, streak gonads, CV, cystic hygaroma
Glitazone function
PPAR-g binding, adiponectin
Amitriptyline
TCA
TCA side effect
antimuscarinic, antihistimine, anti adrenergic
caMP effects on heart and vessels
more contractility, vessel dialation
Measles tx supplement
vit a
split s1
bundle branch block
wide split s2
ASD
Thiamine
pyruvate dehydrogenase, transketolase, a-ketoglutarate dehydrogenase
riboflavin
FAD
biotin
carboxylases
Pyridoxine
transamination/decarboxylases
hemophilia tx
desmopressin to secrete VIII and VWF
Amphotercin B side effects
kidney tubules, hypokalemia and hypomangnesimia
Klinfelter
XXY, tall, breasts, no balls
Fragile X
Big balls, jaws, and ears
Oligohydraminos
Lung development
Dobutamine
B1 agonist
Agatroban
blocks thrombin directly
Terberculoid leprosy
Strong TH1 response
Lead porphyrin effects
blocks ALA dehydratase and ferrochelatase
capsofungin target
1,3 b-d-glucan
Coronary steal
Artery dialation with blockage
First dose hypotension
ACE inhibitor
a1 secondary receptor
IP3
Sertraline
SSRI
sertraline side effect
sexual dysfunction
Trisomy 18
small head, big oxiput, small ears, clenched hands, small jaw, rocker bottom feet
Trisomy 13
Patau's - PCKD, PDA, ASD, VSD, microcephaly, bilateral cleft lip, pyloric stenosis
Partial seizure tx:
carbamezapine
Tonic clonic seizure tx:
phenytoin, carbamezapine, valproate
Myoclonic tx
valproate
absence tx
ethosuximide/valproate
Rb function
bind to E2F, prevent transition to S phase
Neutrophil myeloperoxidase Ab stain
P-ANCA, Churg-Strauss, microscopic polyangitis
Churg-Strauss
systemic vasculitis w/ asthma, eosinophilia, oligoneuropathy, pulm infiltrates, and allergies
Eleuprolide
GnRH analog [can be used pulsatile or constantly]
Fabry disease
a-galactosidase A, ceramide trihexoside - risk of renal failaure and acroparasthesias
Methotrexate
mouth ulcers, hepatotox, pulmonary fibrosis, myelosuppression
Surface ectoderm tissues
anterior pituitary, special senses, skin
Neural tube
CNS, posterior pituitary, retina
Neural crest
PNS, pia/arachnoid, heart cushions, skull bones, melanocytes, adrenal medulla
Mesoderm
muscles, bone, blood, other non-GI
Endoderm
GI organs, lungs, parathyroid, thyroid follicles, bladder/urethra
Diffuse esophageal spasm
painful, trouble swallowing, angina-like chest pain
t14:18
Bcl-2, follicular lymphoma
t9:22
philadelphia, bcr-abl
t8:14
c-myc, Burkett's lymphoma
Propionic acidemia
can't convert propionyl CoA into methymalonyl CoA, ketosis and hypoglycemia. Fail to metabolize T,M,V,I
Essential tremor tx
B-blocker
HSP
leuckocytoclastic vasculitis with IgA deposition leading to purpura, abdominal pain, arthralgias, and renal involvement
Tongue first 2/3
Sense: V3, Taste: chorda tympani (vii)
Tongue last 1/3
glossopharyngeal
Listeria tx
ampicillin [infants or immunocompromised at risk for meningitis]
jejunum absorption
fatty acids, ADEK
duodenum absorption
iron
ileum absorption
B12, bile salts
Maternal uncontrolled diabetes
caudal regression syndrome
Maternal hyper vit A
head abnormalities, DiGeorge
Improved mortality in HF
spironolactone
Large polyprotein virus
"+ strand single strand RNA virus
Neonatal hypoxia risk
retinal neovascularization
Wet macular degeneration
gray subretinal membranes, neovascularization
Dry macular deg
drusen dposits
Wet AMD tx
VEGF inhibitors [ranibizumab]
Viruses with nuclear membrane
Herpes
PSGN electron microscopy
lumpy bumpy subepithelial IgG, C3
Carnatine deficiency
impairs fatty acid transport into mitochondria, fewer ketones
IP3
phospholipase C, PKC, Ca
HER2
transmembrane tyrosine kinase receptor
Eczematous dermatitis
epidermal spongiosis, blistering, vesicles, possible type iv hypersensitivity?
phenytoin side effect
gingival hyperplasia
Excessive MMP in wound formation
contractures
IL-10
secreted by TH2 to inhibit TH1, "anti-inflammatory"
Mousy/musty body odor
PKU - associated with mental retardation and eczema
hypocalcemia w/ blood transfusion
citrate chelation
chloramphenicol SE
aplastic anemia
adenosine antiarrhythmic mechanism
inhbits Ca, opens K - slows spontaneous depolarization of nodes
Trigeminal neuralgia tx
carbamezapine [baclofen, valproic acid]
Metronidazole SE
disulfram-like
Mu-receptors
opiod, control pain, euphoria
Foramen ovale
V3
Foramen rotundum
V2
Phenelzine
MAOI
DiGeorge's
issue with 3-4th pharyngeal pouches, thymic aplasia, leading to fewer T cells in lymph paracortex
polymyositis
autoimmune destruction w/ increased CK and a-Jo 1 AB
Eaton Lampert
autoimmune destruction against Ca channels [for Ach]
Celecoxib
selective cox-2 inhibitor
Aspirin tox
Respiratory alkalosis followed by metabolic acidosis
Aflatoxin
p53 mut, HCC
porphyrin accumulation
skin blistering, photosensitivity, uroporphyrinogen decarboxylase def
Mitochondrial reactions [5]
fatty acid oxidation, ketogenesis, TCA, parts of urea cycle, and pyruvate carboxylation
Scarlet fever
GAS. Gray-white throat exudate, sandpaper-like rash
Metformin SE
Elevated lactate levels
Metformin CI
renal failure
Vitamin D activation
kidney tubules, hypokalemia and hypomangnesimia
FTA-ABS
syphilis marker
PAS macrophages
Whipple disease - diarrhea, abdominal pain, weight loss, joint pain
JAK/STAT signalling
cytokines, GH, prl, IL2
thymic tumors
pure red cell aplasia via autoimmunity
Pompei's
type ii - glycogen buildup in lysosomes
McArdle's
type v - no glycogen phosphorylase in muscle
Von Glerke's
No glucose 6-phosphatase in liver
Lacunar infarcts
hypertensive arteriolar sclerosis of the small penetrating arterioles
C diff toxin A
attractin neutrophils
C diff toxin B
cause mucosal damage via actin cytoskeleton
colchicine
affects tubulin in microtubules
colchicine SE
gut
Silver stains with slow growth on charcoal-yeast with systeine
Leigonella
NO synthesis
arginine
t15:17
APML: retinoic acid receptor,
CD19
B cell
CD15
neutrophil
CD16
NK cell
Hydralazine mech
Dialates arterioles
Hydralazine SE
sodium and fluid retention due to baroreceptor, renin
IFN-G
Produced by TH1 cells, upregulates macrophages
Immunoglobulin deficiency
X-linked agammaglobulinemia
Transtentorial herniation
Uncal herniation, occularmotor paralysis, PCA compression [hemianopsia]
PCA compression
hemianopsia
Acute intermittent porhyria
HMB synthase deficiency - abdominal pain, neuro changes, urine color change on standing
Acute intermittent porphyria tx
IV dextrose [inhibits ALA synthase]
Lactase positive on McKonkee
pink
Parvovirus B19
"slapped cheeks", low grade fever
Torsade de pointes antiarrythmic
Class III [AS]
Etoposide mech
topoisomerase II inhibition, ds breaks
Takayasu arteritis
very similar to GCA, affects aortic arch
Thromboangitis obliteras
Smoking association, thrombosing vasculitis of medium arteris, especially of the hand
Oseltamavir mech
Neuraminidase inhibitor, prevents particle release
Iron metabolism control
Hepatocytes - hepcidin
Optic neuritis
visual disturbances w/ painful eye movement
Polycythemia + heat
itching
Recovery phase of ATN
electrolyte LOSS
Kussmall's sign
paradoxical rise in JVP w/ inspiration, indicative of constrictive paradarditis
Gestational supine hypotension
IVC compressed by uterus
Ribavirin mech
hypermutation via nucleotide analoge
Raltegravir
HIV integrase inhibitor
Indinavir
HIV protease inhibitor
Amantadine
Influenza uncoating
Enfuvirtide
HIV entry/fusion inhibitor
Lentigo's
tan/brown macules due to sun exposure
Purpurae vs petichiae
purpura: between 5-10 mm
Fragile X mech
excess methylation due to CGG repeats
Mononucleosis activated lymph
CD8
Ureter relation
Lateral to the internal iliac, medial to the gonadal vessels
true vocal cord lining
stratified squamous
High free fatty acids/triglycerides
insulin resistance
Beta hydroxybutyrates
marker of insulin deficiency
immunocompromised esophagitis
CMV, HIV, candida
Phase 0 of the SA node action potential
Ca
Timolol
Decreased production of aqueous humor by ciliary body
Prostaglandin F2a [latanoprost, unoprostone, travoprost]
increases outflow of aqueous humor
Cholinomimetics [pilocarpine, carbachol]
increases outflow of aqueous humor
Bacteroides tx
piperacillin, tazobactam
Piperacillin/tazobactam
Gram - rods, pseudomonas
Shizoaffective disorder
schizophrenia + mood disorder [2 wks psychosis w/o mood]
S-100
marker of neural crest cells - schwann and melanocytes
biphasic pattern of cells
Antoni pattern of schwannomas - palisading
Ezetimibe
inihibits cholesterol uptake from brush border?
Gemfibrozil tox:
myopathy, especially with statins
Second generation antihistimines
minimal sedative and antimuscarinic effects [no BBB crossing]
First generation antihistamines
hydroxyzine, promethazine, chlorpheniarmine, diphenhydramine
Glomus tumor
small cancer under nail - from Glomus bodies, which shunt blood away or to skin [thermoregulation]
Waxing and waning lymphadenopathy
Follicular lymphoma, t14:18, bcl2
Recurrent hemorrhagic stroke
cerebral amyloid angiopathy
Zileuton
Leukotriene inhibitor
Cystinuria
same transporter in gut and kidney, deficiency causes increased stones
Psoas muscle origin
Vertebral transverse processes
Nitrate side effects
headaches and cutaneous flushing
MCC of aortic dissection
HTN
Varicose veins skin finding
statis dermatitis
6-MP metabolism
Xanthine oxidase
6-MP activation
HGPRT
Lead poisoning d-ALA cofactor elevation
Pyridoxal phosphate
HUS anemia mechanism
microangiopathic hemolysis
Polyribosyl-ribitol-phosphate
H. flu capsule
"Rose spots", HSM, bloody diarrhea
Typhoid fever
B1 deficiency
Beriberi/Wernicke Korsakoff, peripheral neuropathy, HO cardiac failure
B6 deficiency
cheilosis, glossitis, dermatitis, peripheral neuropathy
Niacin deficiency
pellagra: dememtia, dermatitis, diarrhea
Septic shock cytokine
TNFa
Ethambutol SE
visual acuity
Fever, rash, oliguria after B-lactam use
Drug induced acute interstitial nephritis
Chronic lymphedema
Angiosarcoma
Atypical PKU
Combined Biotin deficiency - inability to produce dopamine
Craniopharyngioma derivatives
Rathke's pouch, pituitary gland precursor
RA mimic
Parvovirus, arthritis resolves spontaneously
Leukotriene B4
Attracts neutrophils
Puberty _ anosmia
Kallmann syndrome - failure of GnRH neurons to migrate
Kallman syndrome
failure of GnRH neurons to migrate
Focal neurological signs and a carotid bruit
Possibility of vascular dementia
Acute onset of MS changes
delirium
Reye's syndrome hepatic damage
Microvesicular hepatitis
Vitamin K mechanism
Glutamate carboxylation
MCC kidney stones
Idiopathic hypercalciuria [normocalcemia]
SRY
testes determining factor [no ovaries]
Mullerian inhibiting factor production
sertoli cells
17a-hydroxylase def
accumulation of progesterone/aldosterone shunting [impaired androgen synthesis + HTN]
21a-hydroxylase def
accumulation of 17-progesterone/shunting to androgens [hypotension + virulization]
11a hydroxylase def
accumulation of deoxycorticosterone/androgen shunting [HTN + virulization]
PE driving factor
hypoxia leading to hyperventillation leading to respiratory alkalosis
IHC: chromogranin
neuroendocrine markers [small cells]
Middle meningial artery source
Maxillary artery [external carotid]
CF vitamin deficiency
ADEK
Vit A deficiency
squamous metaplasia - maintaining cell differentiation
H Pylori location in the stomach
Antrum
T cell positive selection location
Thymic cortex
T cell negative selection loc
Thymic medulla
Pancreatitis damage source
trypsin
Superior saphenous ven harvesting
Inferolateral to the pubic tubercle
doxorubicin cardio tox
dialated cardiomyopathy
Extramedulllary hematopoiesis
Severe chronic hemolytic anemias
Thalassemia mechanism
Mutations cause defective mRNA processing
T-Cell vs B-Cell ALL
T cell has mediastinal masses
Derivative of the common cardinal veins
SVC
Super painful otitis externa
Pseudomonas
Hypopigmented skin patches
Tinea versicolor, caused by malassezia furfur
HCTZ effect on CA
Hypercalcemia [can prevent stones]
Diverticulum formation
pulsion [straining]
Hydralazine + renal perfusion drug
Fenoldopam
Flurazepam
Long acting benzo
PSGN prognosis
age
Floppy neonate with mild jaundice, enlarged tongue, umbilical hernia
hypothyroid
PAO2 formula
150 - (PaCO2/0.8)
Hirshprung's
Rectum involvement, then sigmoid!
Portal hypertension without biopsy congestion
portal vein thrombosis
Portal hypertension tx
Bosentan - endothelin blocker
Concentric calcification in tumors
Psammoma bodies
Lipoic acid
Similar to thiamine, needed in pyruvate dehydrogenase, a-ketoglutarate dehydrogenase
Loudest hypertrophic CM murmur
low preload - sudden standing
Cyroptococcus
India ink, budding yeast
Rubber/dyes exposure
Bladder cancer
NRTI mech
No 3'-OH
Akathisia
Restlessness due to antipsychotics
Primidone
Metabolized to pheobarbital
Lesch-Nyhan
Self mutilation, HGPRT deficiency leads to increased synthesis via phosphoribosyl pyrofphosphate amidotransferase
APL vs AML
APL has a greater risk of hemorrhage
S. epidermidis endocarditis tx
vanco
Ataxia-telangectasia gene
ATM
Vitamin E deficiency
Dorsal column, Spinothalamic tract [fatty acid oxidation]
Cholestyramine TG effect
Inc Tg
Propranolol effect on kidneys
Decreased Renin
Burnt sugar diapers
Maple Syrup urine disease - metabolism of branched chain amino acids fees into TCA via a-ketoglutarate dehydrogenase
Constricting Efferent arteriole [GFR/FF]
Both increase
Myoclonus
jerk
Dystonia
sustained contraction/spasm
Selective B1 blockers
Atenolol. Esmolol, metoprolol, nebivolol
Follicular lymphoma
t14:18, bcl-2
Serum heterophile tests
Sheep RBC agglutination - EBV
Sudden death after heart attack
V Fib
Dialysis metabolism
Reduced Vit D activation, phosphate retention
Colon cancer mutations
APC, KRAS, p53
Statistical power
1-beta
HIV binding receptors
CD4
B1 receptors
Heart and JGA
B2 receptors
vascular smooth muscle
Dopa metabolism vitamin
B6
UV DNA damage
T-T dimers
Source of nitrogen for urea
Aspartate and Arginine
Arsenic/PVC exposure
Liver angiosarcoma, CD31
Prolactin adenoma
suppresses GnRH
White red spots - Koplik
Measles
Proteinuria + IgG to phospholipase A2
Membranous glomerulonephropathy
Homonymous hemianopia with loss of pupillary reflex
Optic tract: before the lateral geniculate nucleus
Cyanide tox tx [especially w/ nitroprusside]
sodium thiosulfate
c-ANCA/Wegner's
RPGN
Chlorapromazine
anti-psychotic, can cause corneal deposits
Thioridazine
can look like retinitis pigmentosa
Atypical depression
Hyperphagia, hypersomnia, weight gain - tx with MAOI's [phenelzine/tranylcypromine]
Paralysis of upward gaze
Pineal tumors, right above the midbrain. Possible BHCG production
Phentolamine
alpha blocker
Listeria spread
food
Headache with nose congestion, tears
Cluster
Anaphalaxis marker
Tryptase - mast cell degranulation marker
Procollagen
Secreted, needs to have N/C terminals cleaved, lysyl crosslinking
Metyrapone
Inhibits 11-hydroxylase. [stimulation test, should see a ACTH spike]
Amiloride
ACEi
Germ tubes on microscopy
Candida
Electron dense deposits in the mesangium
IgA nephropathy [Berger's]
QT prolongation
K channels affected - possibly Romano Ward syndrome
FAS gene
apoptosis, important in T cell clonal deletion
Dorsal column involvement w/ vit def
B12
Phenoxybenzamine
alpha blocker
alpha adrenergic effect on pancreas
decrease insulin release
Earliest microscopic change on MI
4 hours
Anal fissure location
posterior midline
DiGeorge's chromosome
deletion on 22
Isoproterenol
B2 [low dose] and b1 agonist
N-acetylcystine mech in CF
reducing disulfide bridges in mucus
gamma-glutamyl transpeptidase
marker of biliary tree disease [vs bone or hepatocyte]
RNA polymerase I
rRNA
Amyl nitrate
antidote for cyanide poisoning, methemoglobin binds on CN instead of mitochondria
IgA cleavage organism
Strep pneumo
Diastolic heart dysfunction
low compliance heart, can't fill during diastole, higher diastolic pressures
Influenza immunity
hemagglutinin antibodies
Clozapine SE
Agranulocytosis -> get CBC
Ziprasidone SE
Prolonged QT
Lithium + amiodarone SE
hypothyroid
NNRTI drugs
Nevirapine, efavirenz, delavirdine
Enfuvirtide
HIV fusion inhibitor
Strawberry hemangioma prognosis
Grow, then regress by age 7
Phosphatidylcholine in bile
Lower stone risk
Metanephric ducts
form nephrons
Ureteric bud
form everything but nephrons
Systemic inflammation cytokines
TNFa, IL1, IL6
Sickle cell organism vulnerabiltity
Functional asplenia, Pneumococcus or H flu
Bicuspid aortic duct
Aortic stenosis at age 60
Chalky white fat necrosis
Pancreatic fat digestion
Sporothrix schenckii
Rose thron prick
Oral ulcers, medullary thyroid cancer
MEN 2B
Increasing HDL
Niacin better than Diet/exercise
Superficial sulcus tumor
Pancost, affects brachial plexus
Mediastinal mass
Can cause SVC syndrome
Appetite suppressent SE
Pulmonary hypertension
C perfringens toxin
Lecithinase, affecting phospholipids
Pitting nails, trouble swallowing, anemia
Iron deficiency
Sorbitol metabolism
In other tissue rather than the lens, fructose formed via sorbitol dehydrogenase
LMW heparin
Binds to factor Xa better than thrombin [compared against unfractionated]
Neutrophils and steroids
Increases PMN count, because they fall off walls.
Hyperkalemia, NV, confusion, anorexia
Digoxin toxicity
Cyproheptadine
antihistamine w/ antiserotonergic properties
Neonatal hypopigmentation of basal ganglia + mental retardation
Think PKU - phenylalanine hydroxylase
Acute acalculous cholecystitis
acute GB inflammation after major damage - sepsis, trauma, surgery, infections, burns, etc
Alzheimer's most affected regions
Temporal lobes, hipocammpus
Mu receptor ion activity
Increases potassium outflow
Sx of acute hepatitis
Dark urine, fatigue, fever
Joint pain + hematuria
HSP
Urticaria
hives - dermal edema
Complement binding portion of IgG
Part in front of Fc
ACE expression
vascular endothelium
Cladribine
purine analog resistant to adenosine deaminase, used to treat hairy cell leukemia
Pro-carcinogen metabolism
P450 [microsomal monooxygenase]
PTH bone reabsorption
subperiosteal
Polyarteritis nodosa association
Hep B
G+ bacteria staining for aniline
Diptheria
Reid index of lung
mucous layer/wall thickness [chronic bronchitis]
Myc proteins
transcription factors [bind to DNA]
Half life formula
t 1/2 = (Vd * 0.7) /Cl
Riboflavin measurement
Erythrocyte glutathione reductase assy or urinary riboflavin excretion
Riboflavin enzymes
succinate dehydrogenase
Ebstein's anomoly
Lithium side effect, atrialization of the right ventricle
Viral reassortment
Segmented viruses exchanging genetic material
Viral recombination
nonsegmented viruses exchanging genetic material
Activate TH1 cells
IFN-g, IL-12
Citalopram
SSRI - sexual dysfunction
Fluphenazine
traditional antipsychotic - extrapyramidal
Mycoplasm anemia
cold-agglutinin autoimmune hemolysis
Carcinoid heart disease
Fibrinous deposits and endocardial thickening
Cysteine-tellurate agar
Corneybacteria diptheria
Integrin ECM binding
Fibronectin
Ankylosing spondylitis complication
Respiratory involvement - joint pain, fibrosis
Brassy cough, stridor
Parainfluenza
Xenodermata pigmentosum
base excision repair, especially with endonucleases [not exo!]
Vitamin C action
Collagen AA hydroxulation in rough ER
Glycogen stores
12-18 hours
Methylmalonyl CoA to Succinyl coA
isomerization
Acyclovir toxicity
nephrotox, need aggressive hydration
Gout crystals [specifically]
monosodium urate, not uric acid!!!!!!!!!
Bupropion SE
seizures
Drugs w/ SE of seizure
INH, buproprion, imipenem
TCA side effects
anticholinergic [urinary retention], cardiac arrythmia [QT], orthostatic hypertension, sedation
Normal pressure hydrocephalus
only cortical damage
C1 esterase deficiency
Careful w/ ACEi - bradykinin accumulation leading to angioedema
Cherry red epiglotitis
H flu
intranasal ulcer + oligouria
Waegners granulomatosis
HIV protease inhibitor SE
Cushingoid
Ethosuximide mechanism
Decreased calcium current in thalamus
Anti-carcinoid
Octreotide [sdomatostatin analogue]
COX2 expression
only in inflammatory cells
nitroblue tetrazolium neutrophil stain
nadph oxidase check
Insulin responsive cells
fat and muscle
CF nasal transepithelial potential difference
More negative, b/c less chloride secretion and more Na uptake
Increased acid secretion due to H Pylori
Duodenal ulcers
Bronze diabetics
Hemochromatosis
Glanzman's thrmbasthenia
Gp ii/iiia def
Loop diuretic specific point of action
Thick ascending loop
Hep B vs Hep C HCC
Hep B has DNA integration
Lingual thyroid
Failure in migration
Duodenal ulcers
Rarely malignant
Retinoblastoma cancer risk
osteosarcoma
Asbestos cancer risk
Higher risk of bronchogenic carcinoma than mesothelioma
TB exposure
Replication in macrophages until activation
16S rRNA
binds to a sequence upstream of start?
23s rRNA
forms peptide bond
Mitochondrial disease
Exclusively maternal, affected by heteroplasmy
Permanent central DI
hypothalamus damage, not posterior pit
Vitamin A overdose
dry skin, HSM, vision problems, headache, vomiting
flu progressing to pneumonia
staph aureus
Statin SE
myopathy + hepatotox
Medullary kidney cysts
Medullary sponge kidney, risk of stones.
thiopental redistribution
from brain to skeletal muscle
Left ventricular pacemaker leads
run through the atrioventricular/coronary sinus
ATN affected areas
PCT and loop
Gastric erosions
Not past the mucosa, not into the muscularis mucosa
Crohn's CD4
TH1
UC CD4
TH2
Daptomycin SE
myopathy and CPK
Linezolid SE
thrombocytopenia, optic neuritis, serotonin syndrome
Daptomycin mech
punching holes in membranes
phosphatidylcholine
surfactant
MCC iron def in US
blood loss
Interparanchymal hemorrhage
Charcot Bouchard pseudoaneurysms
Organophosphates
inhibit cholinesterase in muscarinic and nicotinic receptors
Fastest sugar metabolism
Fructose: bypasses 1-6 bisphosphate regulation
E2F inhibition
Diptheria and psudomonas toxin
BRAF malignancy (V600E)
melanoma
Nonrhythmic conjugate eye movements in children + myoclonus and abdominal mass
Neuroblastoma [adrenals]
Osteomyelitis
primarily affects long bone metaphysis because of vascularity
Alkaptouria
Black urine due to homogentisic acid buildup - causes pigment deposits throughout and joint restriction
NF-KB
stimulates cytokine produciton [Crohns]
Chronic lung rejection
Affects small airways - bronchiolitis obliterans
MCC meningitis
S. pneumo
Ecoli that doesn't fermewnt sorbitol or produce glucuronidase
O157:H7, EHEC produces shigatoxin - inactivates ribosomal subunits
Theophylline OD
Think Caffeine OD: abdominal pain, vomiting, seizures
Wiskott-Aldrich
eczema, thrombocytopenia, freq infections
Elastin crosslinking
lysine bridges [unhydroxylated]
PAS inclusions in liver [not macrophages]
a1 antitrypsin def
Niacin mech
decrease synthesis of triglycerides and VLDL
antidepressants +bipolar
mania
Aspergillus branching
acute angles, Y
Generalized lymphadenopathy w/ epilepsy drug
phenytoin
Carbamezapine SE
agranulocytosis
Carbamezapine uses
trigeminal neuralgia, partial seizures, diabetic neuropathy, bipolar, tonic clonic
Valproate SE
hepatotox, teratogen
Phenytoin uses
tonic clonic, status epilepticus,
phenytoin side effects
cosmetics, generalized lymphadenopathy,
Hypoglycemic symptoms
From adrenergic effects - nonspecific beta blocker prevents
Sickle cell vitamin def
FA, B12
Dematitis herpetiformis
Extensor surface vesicles associated with Celiac
Multiple Auer rods
APML
Bactrim hypersensitivity
Serum sickness, Type III
Short acting benzo
Triazalam
Long acting benzo
Diazepam, Flurazepam, chordiazepoxide
Best way to improve mitral regurg
decrease afterload
Short term RA therapy
corticosteroids
MMR vaccine type
live attenuated
Killed vaccines
Hep A, rabies
Post gonococcal infection of rash, knee pain, conjunctivits
Reiter's syndrome, for reactive arthritis - Association with HLA-B27 and alkylosing spondilitis
Enoxaparin
LMW heparin
Nipple inversion
infiltration of the suspensory ligament
Niacin flushing SE mech
prostaglandins
Super high proliferation fraction
think Burkett's lymphoma, caused by EBV?
Anti-centromeric AB
CREST syndrome
Anti-DNA topoisomeraseI [Scl-70]
Diffuse scleroderma
EBV binding receptor
CD21
Mitochondrial vacuolization
irreversible cell injury
Cortisol effects on epinephrine
Cortisol activates PNMT (converting norepi to epi)
Vagina fish odor on KOH
Gardnerella vaginalis [bacteria - also clue cells]
PSGN HS type
III - immune complex
Edema-factor like toxins
Anthrax, and Pertussis
Pneumonia + diarrhea
Leigonella
Li Fraumeni syndrome [p53]
family history of multiple cancers at < 45 yo
Class III antiarrythmics
Dofetilide, ibtilide, amiodarone, sotalol
Mannitol SE
pulmonary edema
Phage conversion
Diptheria toxin
Transformation
S. pneumo capsule
Conjugation
E coli antibiotic resistance
Amennorhea from antipsychotic
think pregnancy or dopamine antagonism
Mucin secreting cells in alveoli w/ tan colored fluid
bronchioalveolar carcinoma
Liver with ground glass appearance - finely granular eosinophilic
Hep B
Lymphoid aggregates in liver, w/ macrovesicular steatosis
Hep C
Diuretic ototoxicity
loop diuretics
Major basic protein
Released by eosinophils against helminths
Meconium ileus
CF
Niacin synthesis
tryptophan
gp120
attaches to target cells
gp41
allows for penetration
Lowest PVR
At FRC
Muscarinic activity on blood vessels
Receptors on endothelial surface, binding causes NO/EDRF release
Oropharyngeal candidiasis tx
nystatin [not ampho b]
Highly lipophilic drug clearance
liver
Polyarteritis nodosa artery sparing
Pulmonary
Low serum sodium + pneumonia
leigonella
Serotonin syndrome antibiotic
linezolid
Progressive ataxia, with dorsal collumn involvement [deficiency]
Vitamin E def
Apo E lipoprotein
Liver reuptake
Turner's valve defect
bicuspid aorta
Continuous infusion steady state
4-5 half lives
Nitrites effect on Hgb
methemoglobin
Antibiotic modification resistance
Aminoglycosides
Liver acetylation speed
Risk of drug-induced lupus [more in slow]
CFTR channel gating
ATP
Lateral bowing of the legs
Vit D deficiency
Uremia effect on coagulation
isolated platelet dysfunction
Breast milk vitamin deficiency
Vit K and D
Tx for claudication and platelet aggregation
Cilostazol (Phosphodiesterase III inhibitor)
brain tumor with hair-like gial processes and microcysts
Pilocytic astrocytoma
UTI w/ dysuria and hematuria
hemorrhagic cystitis, caused by adenovirus
Histone methylation
suppress gene transcriptoin
E-selectins and Sialyl Lewis
rolling
ICAM and integrins
adhesion
PECAM and integrins
diapedesis
Lecithin-sphingomyelin ratio
marker of fetal lung development
Modified smooth muscle cells of the afferent arteriole
JGA
Digoxin clearance
Renal
Disproportionately short limbs and stature
Achondroplasia
Gohn complex
nodule with ipsilateral adenopathy
Mood stabilizers
lithium, valproate, carbamezapine
DM, necrolytic erythemia, anemia
gulcagonoma
Lipoprotein lipase deficiency
high TG, skin xanthomas, pancreatitis
Atherosclerosis growth factor
Platelet derived
Heart cushion origin
Neural crest
Human placental lactogen
Like prl and GH, cause insulin resistance
Blotchy red muscle on Gomori trichome
Mitochondrial myopathy
How does digoxin reduce HR
Baroreceptor parasympathetic outflow
HUS coagulation
like TTP, only platelets consumed
Jervell and lange-Nielsen syndrome
Long QT + sensorineural deafness
Myxomatous change in artery wall
Fragmentation of the elastic tissue like in Marfan's
Chronic rejection
Obliterative vascular fibrosis
Angiogenesis
VEFG and FGF
Cromolyn
Prevents mast cell degranulation
G6PD inheritance
X-linked recessive
Verapamil SE
constipation, gingival hyperplasia
Mushroom toxins
Amatoxins inhibit mRNA synthesis
Green color of pus
Myeloperoxidase
Urinary stone prevention
citrate [Ca stabilizing]
Very long fatty acids
Peroxisomes
Ischemic CNIII
Diabetes, either somatic or parasympathetic, not both
P bodies
cytoplasmic mRNA regulatrion
Hyperlipidemia tx and gout
niacin
Dorsal column and lateral corticospinal tracts
B12 deficiency
Anemia deficiency requiring parenteral
B12 deficiency
Radiolucent stones
uric acid
Staghorn calculi microbe
Proteus infection
Stuck on skin appearance
seborrheic keratosis
ARDS
Endothelial cell damage
Endometreitis organism
bacteroides
Grouped vesicular rash
VZV
Acute stress disorder
< 4 wks
HIV temporal encephalopathy: increased signal
HSV
Porphirobilinogen accumulation
Acute intermittent porphyria
Uroporphyrinogen III accumulation
Porphyria cutanea tarda
Amiodarone tox
Interstitial pneumonitis
Bronchoconstriction signalling
leukotrienes
Impetigo organisms
S. aureus, GAS
Drug efflux pump energy source
proton gradient
High levels of testosterone in testes
Androgen binding protein produced by sertoli cells
Glucagon receptor
like B2, Gs protein and cAMP
Gubernaculum in females
Round ligament
platelet aggregation factor
phospholipid acting via IP3 to cause a1 like effects
Pyruvate Kinase
G6PD pathway
Acyl CoA dehydrogenase deficiency
Inability to make ketone bodies when starving
Immediate tx of hepatic encephalopathy
Acidify the intestines - excreting NH3
Invariant chan in HLA II
Placeholder for antigen, gets digested
DiGeorge heart
Truncus arteriosus malformation
Huge swollen macrophages w/ lysosomal storage defect
Gaucher's 0 glucocerebrosidase
Congestive hypersplenia appearance
Red pulp expansion
Shistosomiasis manifestatiosn
Urinary, intestinal, and hepatic
Shistosomiasis transmission
snails
Allergic asthma control
leukotrienes
Porcelain gallbladder
Risk of GB carcinoma
HbS mechanism
Allows hemoglobin stacking when deoxygenated
HMP shunt
Transketolase to from ribose
Calcineurin
Involved in TCR signalling to induce IL-2 expression
Amonia toxicity metabolism depletion
a-ketoglutarate and glutamate
Modafinil
Narcolepsy tx
Genetic reassortment requirement
segmentation of genome
Wilson's tx
penicillamine
GTP synthesis from TCA
succinyl CoA -> succinate
Most common location of colon cancer
Rectosigmoid
Selective IgA deficiency
Hypersensitivity against IgA
Parietal cell location
superficial glands of stomach
NADPH
fat, cholesterol, steroid synthesis
Opiod precursor
POMC, like ACTH
Halothane SE
Massive hepatitis, 4 days post
Arsenic antidote
Dimercaprol
Trousseau's syndrome
migratory thrombophlebitis, causing sterile deposits on endothelial surfaces [heart valves?]
Femoral neck fracture risk
medial circumflex
Varenicline
Partial agonist of nicotinic receptors [smoking cessation]
Sickle cell trait
Papillary necrosis
Down's cancer
ALL
LV supply
Diaphragmatic surface supplied by posterior descending - RCA
Ticlopidine
like clopidogril [ADP] but risk of neutropenia
Scoliosis w/ tall, long extremities
Think marfan's
Inhaled steroids SE
Rinse mouth to prevent candidiasis
Meniere's disease
Increased endolymph causing tinnitus, vertigo, hearing loss
Alendronate
Bisphosphonates - like pyrophosphate
Sodium cyanide test for urine stones
Cystiuria
Penicillin analogue
D-ala D-ala
Early galactose intolerance
UDP-galactose transferase
positive Tzanck stain
Nuclear inclusions in keratinocytes and MNGC
Colon effects of Cox 2 overexpression
Adenomas
RNA virus replicating in nucleus
Influenza [orthomyxy]
substrates for heme synthesis
glycine and succinyl-CoA
HIV colitis
CMV